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The map label for this gene is tesB2 [H]

Identifier: 121638492

GI number: 121638492

Start: 2896743

End: 2897588

Strand: Reverse

Name: tesB2 [H]

Synonym: BCG_2630c

Alternate gene names: 121638492

Gene position: 2897588-2896743 (Counterclockwise)

Preceding gene: 121638493

Following gene: 121638491

Centisome position: 66.24

GC content: 64.07

Gene sequence:

>846_bases
GTGTCGATCGAAGAGATCCTTGATCTTGAGCAACTTGAGGTCAACATCTACCGAGGAAGCGTGTTCAGCCCCGAATCGGG
CTTCCTGCAACGCACTTTCGGTGGTCATGTAGCCGGCCAGTCGCTGGTGTCGGCGGTGCGCACCGTCGACCCGCGGTACA
TGGTGCACTCGCTGCACGGCTATTTTCTTCGGCCTGGAGATGCCAAGGAGCGCACGGTTTTTCTGGTCGAACGCATCCGC
GACGGTGGATCGCTCTGCACCAGGCGGGTCAACGCAGTCCAGCACGGGGAAACCATATTCAGCATGGCGGCGTCGTTCCA
GACCGAACAGGAGGGCATTACCCACCAAGACGTTATGCCAGCGGCGCCGCCGCCCGACGGCCTGCCGGGGTTGAACTCGA
TCAAGGTTTTCGATGATGCCGGGTTCCGGCAGTTCGACGAGTGGGACGTGTGCATCGTGCCCCGGGAGCGCCTGCGGCTT
TTGCCGGGCAAGGCTTCCCAGCAGCAGGTGTGGCTTCGCCACCGTGACCCGTTGCCCGACGACCCGGTGTTGCACATCTG
TGCACTCGCCTACATGAGCGACCTCACGCTGCTGGGATCGGCACAAGTCAACCACCTCGATGTGCGCGACCAGCTGCAGG
TGGCATCGCTGGACCATGCGATGTGGTTCATGCGACCCTTCCGCGCCGACGAGTGGTTGCTGTACGACCAGTCGTCGCCG
TCGGCCAGCGGCGGTCGTGCGCTGACTCGGGGCGAGATTTTCACACGGTCCGGGGAGATGGTCGCGGCGGTCATGCAGGA
GGGGCTGACCCGCCACCGGCGCGGTCACCGGTCGGTGGGGCAGTGA

Upstream 100 bases:

>100_bases
GGCGAGGCGATGGTGGGCATCAACGTGGACGAGATCGCTGTCGGTCATCGGCTCGCCCAGCGCGGCTGGTGAGAACCCGC
GACGAGCAGACGGTCATCGC

Downstream 100 bases:

>100_bases
GCGGGCTGTGAGCGTTCCACGGGTCGGGGTGCTGGCGCTGCAGGGCGACACCCGGGAGCACCTGGCTGCGCTGCGCGAAT
GCGGGGCCGAGCCGATGACG

Product: putative acyl-CoA thioesterase II tesB2

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHGYFLRPGDAKERTVFLVERIR
DGGSLCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRL
LPGKASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSP
SASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ

Sequences:

>Translated_281_residues
MSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHGYFLRPGDAKERTVFLVERIR
DGGSLCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRL
LPGKASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSP
SASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ
>Mature_280_residues
SIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHGYFLRPGDAKERTVFLVERIRD
GGSLCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRLL
PGKASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSPS
ASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=285, Percent_Identity=36.4912280701754, Blast_Score=169, Evalue=2e-42,
Organism=Escherichia coli, GI1786657, Length=276, Percent_Identity=40.9420289855072, Blast_Score=198, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71988741, Length=296, Percent_Identity=33.7837837837838, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17558508, Length=308, Percent_Identity=32.7922077922078, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI115532456, Length=271, Percent_Identity=33.210332103321, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531889, Length=271, Percent_Identity=33.210332103321, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531885, Length=271, Percent_Identity=33.210332103321, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71982224, Length=321, Percent_Identity=28.6604361370716, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI212645202, Length=260, Percent_Identity=29.6153846153846, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322480, Length=326, Percent_Identity=23.3128834355828, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31535; Mature: 31404

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHG
CCHHHHHCHHHHEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCC
YFLRPGDAKERTVFLVERIRDGGSLCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMP
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCC
AAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRLLPGKASQQQVWLRHRDPLPD
CCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEECHHHHHCCCCCCCHHHHHHHCCCCCCC
DPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSP
CHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
SASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ
CCCCCCEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHG
CHHHHHCHHHHEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCC
YFLRPGDAKERTVFLVERIRDGGSLCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMP
EEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCC
AAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRLLPGKASQQQVWLRHRDPLPD
CCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEECHHHHHCCCCCCCHHHHHHHCCCCCCC
DPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSP
CHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
SASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ
CCCCCCEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]