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The map label for this gene is ppiB [H]

Identifier: 121638467

GI number: 121638467

Start: 2871261

End: 2872187

Strand: Direct

Name: ppiB [H]

Synonym: BCG_2605

Alternate gene names: 121638467

Gene position: 2871261-2872187 (Clockwise)

Preceding gene: 121638464

Following gene: 121638474

Centisome position: 65.64

GC content: 63.97

Gene sequence:

>927_bases
ATGGGCCACTTGACACCGGTCGCGGCGCCCCGATTAGCCTGTGCTTTCGTGCCGACCAATGCTCAGCGACGTGCCACAGC
CAAACGCAAACTCGAACGACAACTAGAGCGCCGCGCCAAGCAAGCCAAACGCCGTCGCATCTTGACTATCGTCGGTGGCT
CACTCGCAGCGGTGGCCGTGATCGTCGCGGTAGTCTTCACGGTGGTGGTCAACAAGGACGACCACCAGAGCACCACGTCA
GCAACCCCCACCGACTCGGCCTCGACCAGCCCCCCGCAGGCCGCGACCGCTCCCCCGCTGCCGCCGTTCAAGCCGTCGGC
CAACCTCGGCGCCAACTGCCAGTACCCGCCGTCGCCGGACAAGGCCGTCAAACCGGTCAAGTTGCCCCGGACCGGCAAGG
TACCCACCGACCCGGCCCAGGTCAGCGTGAGCATGGTGACCAACCAGGGCAACATCGGTCTAATGCTGGCCAACAACGAA
TCGCCGTGTACGGTCAATAGTTTCGTCAGCCTCGCGCAGCAGGGTTTCTTCAAGGGCACCACTTGTCACCGGCTGACCAC
CTCACCAATGTTGGCGGTTCTGCAATGCGGCGACCCTAAGGGCGACGGCACGGGCGGTCCGGGCTACCAGTTCGCCAACG
AATACCCCACCGACCAATACTCGGCGAACGACCCCAAGTTGAACGAGCCCGTCATCTATCCGCGCGGGACACTGGCCATG
GCCAACGCCGGCCCTAATACCAACAGCAGCCAGTTCTTCATGGTCTACCGGGACTCAAAGCTGCCACCCCAATACACCGT
GTTCGGCACGATCCAGGCCGACGGACTGACCACCCTGGACAAGATCGCCAAGGCCGGCGTCGCCGGTGGCGGCGAAGACG
GCAAGCCCGCCACCGAAGTCACCATCACGTCGGTGCTGCTGGATTAG

Upstream 100 bases:

>100_bases
ACATAACAGTTACACGCCAGCAACCCCGCAGGAAATCCGGTGATCAACACGGTTCCCAGTTTCCCATCCCCGGCGTCCGG
GGACGAGGCGGGCCGCGAAC

Downstream 100 bases:

>100_bases
CCCGACGCTCGCCGAGCAGACACAGAATCGCACGAAATCAGCCCGCCCAATGCGATTCTGCGTCTGCTCGGCGGAGAAAA
GCGCGCTACGCGGCCGAGGT

Product: putative peptidyl-prolyl cis-trans isomerase B ppiB

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVFTVVVNKDDHQSTTS
ATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNE
SPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD

Sequences:

>Translated_308_residues
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVFTVVVNKDDHQSTTS
ATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNE
SPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD
>Mature_307_residues
GHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVFTVVVNKDDHQSTTSA
TPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNES
PCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAMA
NAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=148, Percent_Identity=36.4864864864865, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7706339, Length=156, Percent_Identity=33.974358974359, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI24308049, Length=174, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI64276486, Length=154, Percent_Identity=29.2207792207792, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI22547212, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI7657473, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI22547215, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=172, Percent_Identity=31.9767441860465, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=34.1463414634146, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=146, Percent_Identity=35.6164383561644, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=166, Percent_Identity=33.7349397590361, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=31.5068493150685, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=165, Percent_Identity=35.1515151515151, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=33.7349397590361, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357249, Length=174, Percent_Identity=31.6091954022989, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32419; Mature: 32288

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAV
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IVAVVFTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLAQQGFFKGT
CCCCCEECCCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
TCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
CEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEE
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEV
ECCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHE
TITSVLLD
EEEEEECC
>Mature Secondary Structure 
GHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IVAVVFTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLAQQGFFKGT
CCCCCEECCCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
TCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAM
CEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEE
ANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEV
ECCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHE
TITSVLLD
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]