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The map label for this gene is obgE

Identifier: 121638323

GI number: 121638323

Start: 2703417

End: 2704856

Strand: Reverse

Name: obgE

Synonym: BCG_2460c

Alternate gene names: 121638323

Gene position: 2704856-2703417 (Counterclockwise)

Preceding gene: 121638324

Following gene: 121638322

Centisome position: 61.83

GC content: 67.64

Gene sequence:

>1440_bases
GTGCCTCGGTTTGTCGATCGGGTCGTCATCCACACCAGAGCGGGTTCGGGCGGTAACGGCTGCGCTTCGGTCCATCGCGA
GAAATTCAAGCCGCTGGGCGGCCCCGATGGCGGAAATGGCGGCCGGGGCGGCAGCATCGTCTTCGTCGTCGATCCGCAAG
TGCACACCCTGCTCGACTTCCATTTCCGCCCGCATCTCACCGCGGCTTCGGGCAAGCACGGGATGGGCAATAACCGCGAC
GGGGCCGCCGGCGCGGATTTGGAAGTGAAAGTTCCCGAAGGCACCGTGGTATTGGACGAGAACGGCCGGCTACTGGCCGA
CCTGGTCGGCGCGGGCACCCGCTTTGAAGCCGCCGCCGGAGGCCGTGGCGGTTTGGGCAACGCCGCGCTGGCTTCCCGCG
TGCGTAAGGCCCCCGGTTTCGCACTCCTCGGCGAAAAGGGACAGTCCCGAGACCTCACCTTGGAACTCAAGACCGTCGCC
GACGTCGGCCTGGTCGGGTTTCCGTCGGCCGGAAAATCCTCGCTGGTGTCGGCGATTTCGGCGGCCAAGCCGAAGATCGC
CGACTACCCGTTCACCACCCTGGTGCCCAACCTCGGTGTGGTCTCGGCTGGCGAGCACGCGTTCACCGTCGCCGACGTGC
CGGGGTTGATCCCGGGCGCATCCCGGGGCCGTGGTCTGGGGCTGGACTTTCTGCGGCACATCGAGCGCTGCGCTGTACTG
GTGCATGTGGTGGATTGCGCTACCGCCGAGCCGGGCCGCGACCCCATCTCGGACATCGACGCGCTGGAAACGGAACTCGC
GTGCTACACGCCCACGCTGCAAGGGGACGCGGCTCTGGGCGATCTCGCCGCACGGCCGCGTGCGGTGGTCCTCAACAAAA
TCGATGTGCCGGAGGCCCGCGAGCTCGCGGAGTTCGTCCGTGACGACATCGCCCAGCGCGGCTGGCCGGTGTTCTGCGTG
TCGACCGCAACCCGGGAAAACCTGCAGCCGTTGATCTTTGGGCTGTCGCAGATGATCTCGGACTACAACGCTGCGCGGCC
GGTGGCGGTGCCACGGCGGCCGGTGATTCGTCCGATTCCGGTGGACGACAGCGGTTTTACCGTCGAACCCGACGGGCATG
GTGGCTTTGTCGTCAGCGGTGCCCGGCCCGAGCGTTGGATTGACCAGACCAACTTCGACAACGACGAGGCCGTCGGCTAT
CTCGCCGACCGGCTGGCGCGCCTGGGTGTCGAGGAGGAATTGCTGAGGCTGGGTGCGCGGTCAGGATGCGCGGTGACCAT
CGGCGAGATGACGTTCGATTGGGAGCCGCAAACGCCTGCGGGTGAGCCGGTCGCGATGTCCGGCCGGGGCACCGATCCGC
GGCTGGACAGCAACAAGCGGGTGGGCGCGGCCGAGCGAAAGGCCGCTCGGAGTCGGCGTCGCGAACACGGGGATGGCTGA

Upstream 100 bases:

>100_bases
TCGACCACTGCCTGAGCGTCGCGCGTGTGCGCCCACTGCGAAGATTCACGAGGGGCAAAACCCGCAGTAGCTGCACACTC
CGCAGATGAAGGGGAGCTCG

Downstream 100 bases:

>100_bases
TGAGAAGTCCGCATCGGGACGCAATCCGGACCGCGCGCGGCCTTGTCGTGAAGGTCGGGACCACGGCGCTTACCACACCG
TCCGGGATGTTCGATGCCGG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRD
GAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVA
DVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVL
VHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCV
STATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGY
LADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG

Sequences:

>Translated_479_residues
MPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRD
GAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVA
DVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVL
VHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCV
STATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGY
LADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
>Mature_478_residues
PRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRDG
AAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVAD
VGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVLV
HVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCVS
TATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYL
ADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=343, Percent_Identity=44.3148688046647, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI111955139, Length=309, Percent_Identity=37.8640776699029, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI111955063, Length=193, Percent_Identity=37.3056994818653, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI58761500, Length=132, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789574, Length=341, Percent_Identity=42.5219941348974, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1787454, Length=162, Percent_Identity=32.7160493827161, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=336, Percent_Identity=38.9880952380952, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=318, Percent_Identity=31.7610062893082, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17509631, Length=134, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=205, Percent_Identity=35.609756097561, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=31.2056737588652, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=107, Percent_Identity=37.3831775700935, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI20129375, Length=330, Percent_Identity=38.1818181818182, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24585318, Length=319, Percent_Identity=35.1097178683386, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=29.6875, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=29.6875, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=29.6875, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_MYCBO (Q7TYK5)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_856114.1
- HSSP:   P20964
- ProteinModelPortal:   Q7TYK5
- SMR:   Q7TYK5
- EnsemblBacteria:   EBMYCT00000015539
- GeneID:   1094248
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2467c
- GeneTree:   EBGT00050000015858
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12296
- BioCyc:   MBOV233413:MB2467C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 50462; Mature: 50330

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDF
CCCHHCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHH
HFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAG
CCCCCEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCEEHHHHCCCCEEEECCC
GRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAIS
CCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEHHCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEAR
HHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCEEEEECCCCCCHH
ELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIP
HHHHHHHHHHHHCCCCEEEEECCCHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECC
VDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGAR
CCCCCCEECCCCCCCEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCC
SGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
CCCEEEECCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDF
CCHHCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHH
HFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAG
CCCCCEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCEEHHHHCCCCEEEECCC
GRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAIS
CCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEHHCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEAR
HHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCEEEEECCCCCCHH
ELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIP
HHHHHHHHHHHHCCCCEEEEECCCHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECC
VDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGAR
CCCCCCEECCCCCCCEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCC
SGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
CCCEEEECCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972