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The map label for this gene is dhmA2

Identifier: 121637736

GI number: 121637736

Start: 2079884

End: 2080744

Strand: Reverse

Name: dhmA2

Synonym: BCG_1868c

Alternate gene names: 121637736

Gene position: 2080744-2079884 (Counterclockwise)

Preceding gene: 121637738

Following gene: 121637722

Centisome position: 47.57

GC content: 64.58

Gene sequence:

>861_bases
ATGAGCATCGATTTCACGCCGGATCCGCAGCTGTACCCGTTCGAGTCGCGCTGGTTCGACAGCTCGCGTGGACGCATCCA
CTACGTCGACGAGGGCACGGGTCCGCCGATCCTGTTGTGTCACGGCAACCCGACGTGGAGTTTCCTGTATCGGGACATCA
TCGTCGCACTGCGGGACCGTTTCCGTTGTGTGGCTCCGGATTATCTGGGTTTCGGGTTATCGGAGCGTCCCTCGGGATTC
GGGTACCAGATCGACGAGCACGCGCGGGTGATCGGCGAATTCGTCGATCACCTGGGCCTGGACCGCTACCTGAGCATGGG
TCAGGACTGGGGTGGCCCGATCAGCATGGCGGTCGCTGTCGAGCGTGCCGACCGGGTCCGCGGCGTCGTGTTGGGCAACA
CGTGGTTCTGGCCGGCGGACACGCTGGCGATGAAGGCCTTCAGCAGGGTGATGTCCAGCCCGCCAGTGCAGTACGCGATC
TTACGGCGCAACTTCTTTGTCGAGCGCTTGATACCCGCGGGAACCGAGCACCGGCCGAGTAGCGCGGTGATGGCGCACTA
CCGGGCGGTGCAGCCCAACGCCGCGGCACGCCGAGGCGTAGCCGAGATGCCCAAACAGATCCTGGCCGCCCGTCCCCTGC
TGGCACGGCTCGCCCGGGAGGTGCCAGCCACGCTGGGCACCAAGCCCACCCTGTTGATTTGGGGGATGAAGGATGTCGCA
TTCAGGCCGAAAACGATTATCCCCAGACTGAGTGCGACATTTCCCGACCACGTCCTGGTGGAGCTGCCCAACGCCAAACA
CTTCATCCAGGAGGACGCCCCCGACCGGATCGCCGCCGCGATCATTGAGCGCTTCGGCTGA

Upstream 100 bases:

>100_bases
GACAGCCGTCGGCAGCCAGCGGCCACCGTCACGCCACTCCCGGACACTCGGTGATGTCACCCTTCGGGCATACCATCATG
AGCGCGATCGGAGGAGGGTA

Downstream 100 bases:

>100_bases
ACCTTTGTCGCTGAGCACCCCGCAACAGCTGGCATTGTTGGAGCGCGGGTGGCGACACCGAATAGCTCCCCACCCCACCT
CCGACCACGGTCAACCCCGC

Product: haloalkane dehalogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGF
GYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAI
LRRNFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVA
FRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG

Sequences:

>Translated_286_residues
MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGF
GYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAI
LRRNFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVA
FRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG
>Mature_285_residues
SIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFG
YQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAIL
RRNFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVAF
RPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI27597073, Length=203, Percent_Identity=29.5566502463054, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554012, Length=288, Percent_Identity=23.2638888888889, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324392, Length=282, Percent_Identity=24.822695035461, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHMA2_MYCBO (P64304)

Other databases:

- EMBL:   BX248340
- RefSeq:   NP_855516.1
- ProteinModelPortal:   P64304
- SMR:   P64304
- EnsemblBacteria:   EBMYCT00000017005
- GeneID:   1092984
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1864c
- GeneTree:   EBGT00050000015214
- HOGENOM:   HBG748003
- OMA:   SSAVMEH
- ProtClustDB:   PRK03204
- BioCyc:   MBOV233413:MB1864C-MONOMER
- BRENDA:   3.8.1.5
- HAMAP:   MF_01230
- InterPro:   IPR000073
- InterPro:   IPR000639
- PRINTS:   PR00111
- PRINTS:   PR00412

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =3.8.1.5

Molecular weight: Translated: 32151; Mature: 32020

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: ACT_SITE 109-109 ACT_SITE 238-238 ACT_SITE 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDR
CCCCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHH
FRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAV
CEECCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCHHHHHH
ERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVERLIPAGTEHRPS
HHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVA
HHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCHHHC
FRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG
CCCHHHCCCCCCCCCCCEEEECCCCHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDR
CCCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHH
FRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAV
CEECCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCHHHHHH
ERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVERLIPAGTEHRPS
HHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVA
HHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCHHHC
FRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG
CCCHHHCCCCCCCCCCCEEEECCCCHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972