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The map label for this gene is fadD6 [H]

Identifier: 121637135

GI number: 121637135

Start: 1379051

End: 1380844

Strand: Direct

Name: fadD6 [H]

Synonym: BCG_1266

Alternate gene names: 121637135

Gene position: 1379051-1380844 (Clockwise)

Preceding gene: 121637134

Following gene: 121637136

Centisome position: 31.52

GC content: 65.44

Gene sequence:

>1794_bases
GTGTCCGATTACTACGGCGGCGCACACACAACGGTCAGGCTGATCGACCTGGCAACTCGGATGCCGCGAGTGTTGGCGGA
CACGCCGGTGATTGTGCGTGGGGCAATGACCGGGCTGCTGGCCCGGCCGAATTCCAAGGCGTCGATCGGCACGGTGTTCC
AGGACCGGGCCGCTCGCTACGGTGACCGAGTCTTCCTGAAATTCGGCGATCAGCAGCTGACCTACCGCGACGCTAACGCC
ACCGCCAACCGGTACGCCGCGGTGTTGGCCGCCCGCGGCGTCGGCCCCGGCGACGTCGTTGGCATCATGTTGCGTAACTC
ACCCAGCACAGTCTTGGCGATGCTGGCCACGGTCAAGTGCGGCGCTATCGCCGGCATGCTCAACTACCACCAGCGCGGCG
AGGTGTTGGCGCACAGCCTGGGTCTGCTGGACGCGAAGGTACTGATCGCAGAGTCCGACTTGGTCAGCGCCGTCGCCGAA
TGCGGCGCCTCGCGCGGCCGGGTAGCGGGCGACGTGCTGACCGTCGAGGACGTGGAGCGATTCGCCACAACGGCGCCCGC
CACCAACCCGGCGTCGGCGTCGGCGGTGCAAGCCAAAGACACCGCGTTCTACATCTTCACCTCGGGCACCACCGGATTTC
CCAAGGCCAGTGTCATGACGCATCATCGGTGGCTGCGGGCGCTGGCCGTCTTCGGAGGGATGGGGCTGCGGCTGAAGGGT
TCCGACACGCTCTACAGCTGCCTGCCGCTGTACCACAACAACGCGTTAACGGTCGCGGTGTCGTCGGTGATCAATTCTGG
GGCGACCCTGGCGCTGGGTAAGTCGTTTTCGGCGTCGCGGTTCTGGGATGAGGTGATTGCCAACCGGGCGACGGCGTTCG
TCTACATCGGCGAAATCTGCCGTTATCTGCTCAACCAGCCGGCCAAGCCGACCGACCGTGCCCACCAGGTGCGGGTGATC
TGCGGTAACGGGCTGCGGCCGGAGATCTGGGATGAGTTCACCACCCGCTTCGGGGTCGCGCGGGTGTGCGAGTTCTACGC
CGCCAGCGAAGGCAACTCGGCCTTTATCAACATCTTCAACGTGCCCAGGACCGCCGGGGTATCGCCGATGCCGCTTGCCT
TTGTGGAATACGACCTGGACACCGGCGATCCGCTGCGGGATGCGAGCGGGCGAGTGCGTCGGGTACCCGACGGTGAACCC
GGCCTGTTGCTTAGCCGGGTCAACCGGCTGCAGCCGTTCGACGGCTACACCGACCCGGTTGCCAGCGAAAAGAAGTTGGT
GCGCAACGCTTTTCGAGATGGCGACTGTTGGTTCAACACCGGTGACGTGATGAGCCCGCAGGGCATGGGCCATGCCGCCT
TCGTCGATCGGCTGGGCGACACCTTCCGCTGGAAGGGCGAGAATGTCGCCACCACTCAGGTCGAAGCGGCACTGGCCTCC
GACCAGACCGTCGAGGAGTGCACGGTCTACGGCGTCCAGATTCCGCGCACCGGCGGGCGCGCCGGAATGGCCGCGATCAC
ACTGCGCGCTGGCGCCGAATTCGACGGCCAGGCGCTGGCCCGAACGGTTTACGGTCACTTGCCCGGCTATGCACTTCCGC
TCTTTGTTCGGGTAGTGGGGTCGCTGGCGCACACCACGACGTTCAAGAGTCGCAAGGTGGAGTTGCGCAACCAGGCCTAT
GGCGCCGACATCGAGGATCCGCTGTACGTACTGGCCGGCCCGGACGAAGGATATGTGCCGTACTACGCCGAATACCCTGA
GGAGGTTTCGCTCGGAAGGCGACCGCAGGGCTAG

Upstream 100 bases:

>100_bases
GTGGTAGTCGATAACGTCAAGGACGCTCTGCGGGCCTGCGCACCTTCCTGAGGTTGGTCGACAACCAATTCGACATTTCG
CAAACGAATCGAGGGCTTAC

Downstream 100 bases:

>100_bases
CGGATTCCGGGCGCAGTCTCGATACCCGCACTGGACGCTCGACGGTGACCAGGCACTATGGATGCGTGCGTTCAACACCG
CCGGCCTCAGCCGGTCGTTC

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARYGDRVFLKFGDQQLTYRDANA
TANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAE
CGASRGRVAGDVLTVEDVERFATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKG
SDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVI
CGNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEP
GLLLSRVNRLQPFDGYTDPVASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALAS
DQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVGSLAHTTTFKSRKVELRNQAY
GADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG

Sequences:

>Translated_597_residues
MSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARYGDRVFLKFGDQQLTYRDANA
TANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAE
CGASRGRVAGDVLTVEDVERFATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKG
SDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVI
CGNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEP
GLLLSRVNRLQPFDGYTDPVASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALAS
DQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVGSLAHTTTFKSRKVELRNQAY
GADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG
>Mature_596_residues
SDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARYGDRVFLKFGDQQLTYRDANAT
ANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAEC
GASRGRVAGDVLTVEDVERFATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKGS
DTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVIC
GNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEPG
LLLSRVNRLQPFDGYTDPVASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALASD
QTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVGSLAHTTTFKSRKVELRNQAYG
ADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=590, Percent_Identity=37.9661016949153, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI38524616, Length=559, Percent_Identity=37.567084078712, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI40807357, Length=606, Percent_Identity=35.6435643564356, Blast_Score=343, Evalue=4e-94,
Organism=Homo sapiens, GI62865631, Length=593, Percent_Identity=34.9072512647555, Blast_Score=336, Evalue=5e-92,
Organism=Homo sapiens, GI13325055, Length=593, Percent_Identity=34.9072512647555, Blast_Score=336, Evalue=5e-92,
Organism=Homo sapiens, GI13325057, Length=579, Percent_Identity=35.5785837651123, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI227499621, Length=572, Percent_Identity=34.965034965035, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI13236579, Length=515, Percent_Identity=36.504854368932, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI156151445, Length=600, Percent_Identity=22.6666666666667, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI28416953, Length=521, Percent_Identity=23.8003838771593, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI221142682, Length=495, Percent_Identity=25.6565656565657, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17551278, Length=608, Percent_Identity=32.7302631578947, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI115534440, Length=554, Percent_Identity=33.0324909747292, Blast_Score=306, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6319515, Length=517, Percent_Identity=31.5280464216634, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6319699, Length=522, Percent_Identity=23.3716475095785, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20130353, Length=583, Percent_Identity=36.1921097770154, Blast_Score=351, Evalue=7e-97,
Organism=Drosophila melanogaster, GI28573631, Length=583, Percent_Identity=36.1921097770154, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI45550496, Length=567, Percent_Identity=37.7425044091711, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI45552801, Length=567, Percent_Identity=37.7425044091711, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24583465, Length=551, Percent_Identity=35.934664246824, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24583463, Length=551, Percent_Identity=35.934664246824, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI281364798, Length=551, Percent_Identity=35.934664246824, Blast_Score=328, Evalue=8e-90,
Organism=Drosophila melanogaster, GI21355181, Length=467, Percent_Identity=24.1970021413276, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24581924, Length=556, Percent_Identity=23.3812949640288, Blast_Score=96, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 64338; Mature: 64207

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARY
CCCCCCCCHHHHHHHHHHHHCCHHHCCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKC
CCEEEEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
GAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAECGASRGRVAGDVLTVEDVER
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHCCCCCCCCCCCEEEHHHHHH
FATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKG
HHHCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEC
SDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEIC
CCCHHHHHHHHCCCCCEEEHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCHHEEEHHHHH
RYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFN
HHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPV
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCC
ASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALAS
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHCCCCEEECCCCEEHHHHHHHHHC
DQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVG
CCCHHHHEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
SLAHTTTFKSRKVELRNQAYGADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG
HHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHCCCCHHCCCCCCCC
>Mature Secondary Structure 
SDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARY
CCCCCCCHHHHHHHHHHHHCCHHHCCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKC
CCEEEEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
GAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAECGASRGRVAGDVLTVEDVER
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHCCCCCCCCCCCEEEHHHHHH
FATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKG
HHHCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEC
SDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEIC
CCCHHHHHHHHCCCCCEEEHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCHHEEEHHHHH
RYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFN
HHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPV
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCC
ASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALAS
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHCCCCEEECCCCEEHHHHHHHHHC
DQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVG
CCCHHHHEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
SLAHTTTFKSRKVELRNQAYGADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG
HHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA