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The map label for this gene is fbiC

Identifier: 121637105

GI number: 121637105

Start: 1334276

End: 1336846

Strand: Direct

Name: fbiC

Synonym: BCG_1236

Alternate gene names: 121637105

Gene position: 1334276-1336846 (Clockwise)

Preceding gene: 121637103

Following gene: 121637109

Centisome position: 30.5

GC content: 66.63

Gene sequence:

>2571_bases
GTGCCGCAGCCTGTAGGTCGGAAGTCCACCGCTCTGCCGAGTCCCGTTGTACCGCCCCAGGCAAATGCCTCAGCGTTGCG
GCGGGTACTGCGACGGGCCCGAGATGGTGTCACGCTGAACGTGGATGAGGCGGCCATAGCGATGACCGCACGCGGTGACG
AGCTGGCCGACCTGTGCGCGAGCGCCGCGCGGGTGCGCGATGCGGGTCTCGTGTCGGCCGGCCGGCACGGGCCCAGCGGC
AGGTTGGCGATCAGCTATTCGCGCAAGGTGTTTATCCCGGTCACCCGGTTATGCCGGGACAATTGCCACTATTGCACGTT
CGTCACCGTGCCGGGCAAGCTACGCGCCCAAGGTTCCAGCACGTATATGGAACCCGACGAGATCCTCGACGTTGCCCGCC
GAGGTGCCGAATTCGGTTGCAAGGAAGCGCTATTCACTCTCGGTGACCGTCCGGAGGCGCGTTGGCGCCAGGCACGCGAA
TGGCTCGGCGAACGGGGCTATGACTCCACGTTGTCCTACGTGCGCGCGATGGCAATCCGTGTGCTGGAGCAAACCGGGCT
GTTGCCGCACCTGAACCCGGGTGTGATGAGCTGGTCGGAGATGTCGCGGCTCAAACCGGTGGCGCCGTCGATGGGCATGA
TGCTGGAGACGACCTCGCGACGGCTGTTCGAAACCAAGGGGCTCGCCCACTACGGCAGCCCTGACAAAGACCCGGCGGTG
CGGCTGCGTGTCCTGACCGACGCCGGCCGGTTGTCCATTCCGTTTACCACCGGTCTGTTGGTCGGCATCGGCGAGACGCT
ATCCGAGCGCGCCGATACGTTACATGCGATTCGCAAGTCGCACAAGGAGTTCGGGCATATCCAAGAAGTGATCGTGCAGA
ACTTCCGCGCCAAGGAACACACCGCGATGGCCGCCTTCCCCGATGCCGGAATCGAGGATTACCTGGCGACGGTTGCGGTG
GCGCGGCTGGTGCTGGGCCCGGGCATGCGCATCCAGGCGCCGCCGAACCTGGTGTCTGGCGACGAATGCCGGGCGCTGGT
TGGCGCCGGGGTCGACGACTGGGGCGGTGTCTCACCGTTGACGCCCGACCATGTCAACCCCGAACGGCCCTGGCCCGCTT
TGGACGAGCTGGCGGCGGTCACCGCCGAAGCCGGCTACGACATGGTGCAGCGGCTGACCGCGCAACCCAAATACGTACAG
GCGGGCGCGGCGTGGATCGACCCGCGGGTGCGGGGACATGTGGTGGCGCTGGCGGATCCGGCGACCGGCCTGGCCCGCGA
CGTCAACCCGGTGGGCATGCCGTGGCAGGAGCCCGACGACGTGGCGTCCTGGGGCCGGGTCGATCTGGGCGCAGCGATCG
ACACTCAGGGCCGCAATACCGCAGTGCGCAGCGACCTGGCCAGCGCCTTCGGTGACTGGGAATCGATCCGCGAGCAGGTG
CACGAGCTGGCGGTCCGCGCTCCGGAACGCATTGACACCGATGTGCTTGCCGCCCTGCGATCGGCGGAGCGTGCGCCCGC
CGGCTGCACCGACGGCGAGTATCTGGCGCTTGCCACCGCCGACGGTCCTGCGCTGGAAGCCGTTGCCGCACTGGCTGATT
CGTTGCGCCGCGATGTCGTCGGCGACGAGGTGACCTTTGTGGTCAACCGTAACATCAACTTCACCAACATCTGCTACACC
GGTTGCCGGTTCTGCGCGTTCGCCCAGCGAAAGGGTGACGCCGACGCCTACTCGCTGTCGGTCGGAGAGGTCGCCGACCG
GGCATGGGAGGCCCACGTCGCCGGGGCCACCGAAGTATGCATGCAGGGCGGTATCGATCCCGAGCTACCGGTCACCGGCT
ACGCCGATCTGGTTCGTGCCGTCAAGGCGCGGGTGCCCTCCATGCATGTGCACGCGTTTTCCCCGATGGAGATCGCCAAC
GGCGTCACCAAGAGCGGGCTGAGCATTCGCGAGTGGCTGATCGGCCTGCGCGAGGCCGGGCTGGATACCATCCCGGGTAC
CGCCGCGGAAATCCTGGACGACGAGGTTCGCTGGGTGCTGACCAAGGGCAAGCTGCCGACGTCATTGTGGATCGAAATCG
TGACGACCGCCCACGAGGTGGGTCTGCGGTCATCATCGACGATGATGTACGGGCATGTGGACAGTCCACGGCACTGGGTC
GCCCATCTTAACGTGCTGCGCGATATTCAGGACCGTACCGGCGGCTTCACCGAGTTCGTCCCGTTGCCGTTCGTGCACCA
GAATTCACCGTTGTACCTGGCCGGTGCGGCGCGCCCCGGGCCCAGCCATCGCGACAACCGCGCGGTACATGCTTTGGCGC
GGATCATGTTGCACGGCCGCATCTCGCACATTCAGACCAGCTGGGTGAAACTTGGAGTGCGGCGCACCCAGGTGATGCTC
GAAGGTGGCGCCAACGACCTGGGCGGCACGCTGATGGAGGAGACCATCTCGCGGATGGCCGGTTCCGAACACGGATCGGC
CAAGACCGTCGCTGAGCTGGTCGCGATCGCCGAAGGCATCGGCCGCCCGGCGCGCCAGCGCACTACCACATACGCCCTGC
TTGCGGCCTAG

Upstream 100 bases:

>100_bases
CGGCCTGGCGCTACTGTTGCGCTTATGGCGCCAAGGTTGGCCAGCATCTCACCTGGTGGGGCGTGCGGGTGATATCAGAT
TGCAGGGAAGGTATACCAAC

Downstream 100 bases:

>100_bases
CCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCAATCTGGCCTAGCCCCGGCGACGATGCCGG
GTCGCGGGATGGGGCCCGCA

Product: FO synthase

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MPQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTARGDELADLCASAARVRDAGLVSAGRHGPSG
RLAISYSRKVFIPVTRLCRDNCHYCTFVTVPGKLRAQGSSTYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQARE
WLGERGYDSTLSYVRAMAIRVLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAV
RLRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEHTAMAAFPDAGIEDYLATVAV
ARLVLGPGMRIQAPPNLVSGDECRALVGAGVDDWGGVSPLTPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQ
AGAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQV
HELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNRNINFTNICYT
GCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIAN
GVTKSGLSIREWLIGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWV
AHLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQVML
EGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTTYALLAA

Sequences:

>Translated_856_residues
MPQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTARGDELADLCASAARVRDAGLVSAGRHGPSG
RLAISYSRKVFIPVTRLCRDNCHYCTFVTVPGKLRAQGSSTYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQARE
WLGERGYDSTLSYVRAMAIRVLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAV
RLRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEHTAMAAFPDAGIEDYLATVAV
ARLVLGPGMRIQAPPNLVSGDECRALVGAGVDDWGGVSPLTPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQ
AGAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQV
HELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNRNINFTNICYT
GCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIAN
GVTKSGLSIREWLIGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWV
AHLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQVML
EGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTTYALLAA
>Mature_855_residues
PQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTARGDELADLCASAARVRDAGLVSAGRHGPSGR
LAISYSRKVFIPVTRLCRDNCHYCTFVTVPGKLRAQGSSTYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQAREW
LGERGYDSTLSYVRAMAIRVLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAVR
LRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEHTAMAAFPDAGIEDYLATVAVA
RLVLGPGMRIQAPPNLVSGDECRALVGAGVDDWGGVSPLTPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQA
GAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQVH
ELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNRNINFTNICYTG
CRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANG
VTKSGLSIREWLIGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWVA
HLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQVMLE
GGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTTYALLAA

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (Probable)

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the radical SAM superfamily. CofH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FBIC_MYCBO (Q7U0G9)

Other databases:

- EMBL:   AF479769
- EMBL:   BX248337
- RefSeq:   NP_854860.1
- ProteinModelPortal:   Q7U0G9
- EnsemblBacteria:   EBMYCT00000017233
- GeneID:   1090495
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1206
- GeneTree:   EBGT00050000016725
- HOGENOM:   HBG335564
- OMA:   RAGIDDW
- ProtClustDB:   PRK09234
- BioCyc:   MBOV233413:MB1206-MONOMER
- BioCyc:   MetaCyc:MONOMER-12180
- HAMAP:   MF_01611
- HAMAP:   MF_01612
- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR020050
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR00423
- TIGRFAMs:   TIGR03550
- TIGRFAMs:   TIGR03551

Pfam domain/function: PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 92507; Mature: 92376

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTARGDELADLCA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEEECCCHHHHHHHH
SAARVRDAGLVSAGRHGPSGRLAISYSRKVFIPVTRLCRDNCHYCTFVTVPGKLRAQGSS
HHHHHHHCCHHHCCCCCCCCCEEEEECCEEEEEHHHHHHCCCCEEEEEECCCCEECCCCC
TYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQAREWLGERGYDSTLSYVRAMAIR
CCCCHHHHHHHHHCCHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAV
HHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
RLRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEH
EEEEEECCCCEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
TAMAAFPDAGIEDYLATVAVARLVLGPGMRIQAPPNLVSGDECRALVGAGVDDWGGVSPL
HEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCC
TPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQAGAAWIDPRVRGHVVALADP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHCCCCCCCEEEEEECC
ATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQV
CCHHHCCCCCCCCCCCCCHHHHHCCCEEECCEECCCCCCHHHHHHHHHHHCCHHHHHHHH
HELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVV
HHHHHCCCHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHC
GDEVTFVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVC
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHH
MQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANGVTKSGLSIREWLIGLREAG
HHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHCC
LDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWV
CCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
AHLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGR
HHHHHHHHHHHHCCCCCEECCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
ISHIQTSWVKLGVRRTQVMLEGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGI
HHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GRPARQRTTTYALLAA
CCCHHHHCCEEEEEEC
>Mature Secondary Structure 
PQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTARGDELADLCA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEEECCCHHHHHHHH
SAARVRDAGLVSAGRHGPSGRLAISYSRKVFIPVTRLCRDNCHYCTFVTVPGKLRAQGSS
HHHHHHHCCHHHCCCCCCCCCEEEEECCEEEEEHHHHHHCCCCEEEEEECCCCEECCCCC
TYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQAREWLGERGYDSTLSYVRAMAIR
CCCCHHHHHHHHHCCHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAV
HHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
RLRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEH
EEEEEECCCCEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
TAMAAFPDAGIEDYLATVAVARLVLGPGMRIQAPPNLVSGDECRALVGAGVDDWGGVSPL
HEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCC
TPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQAGAAWIDPRVRGHVVALADP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHCCCCCCCEEEEEECC
ATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQV
CCHHHCCCCCCCCCCCCCHHHHHCCCEEECCEECCCCCCHHHHHHHHHHHCCHHHHHHHH
HELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVV
HHHHHCCCHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHC
GDEVTFVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVC
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHH
MQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANGVTKSGLSIREWLIGLREAG
HHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHCC
LDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWV
CCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
AHLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGR
HHHHHHHHHHHHCCCCCEECCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
ISHIQTSWVKLGVRRTQVMLEGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGI
HHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GRPARQRTTTYALLAA
CCCHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11948155; 12788972