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The map label for this gene is mutT2

Identifier: 121637092

GI number: 121637092

Start: 1317939

End: 1318364

Strand: Direct

Name: mutT2

Synonym: BCG_1222

Alternate gene names: 121637092

Gene position: 1317939-1318364 (Clockwise)

Preceding gene: 121637090

Following gene: 121637093

Centisome position: 30.13

GC content: 68.54

Gene sequence:

>426_bases
ATGCTGAATCAGATCGTGGTTGCCGGAGCCATCGTCCGCGGTTGCACGGTCTTGGTGGCGCAACGCGTTCGGCCACCGGA
GTTGGCGGGTCGTTGGGAACTTCCCGGCGGTAAGGTCGCCGCCGGCGAAACCGAGCGCGCCGCGCTGGCCCGAGAGCTCG
CCGAAGAACTGGGACTCGAGGTCGCCGACCTCGCGGTGGGCGACCGTGTGGGCGACGATATTGCGTTGAACGGCACGACG
ACGCTGCGGGCCTATCGCGTGCATCTGCTTGGCGGCGAACCGCGTGCGCGTGACCACCGGGCGCTGTGCTGGGTGACGGC
GGCCGAACTGCACGATGTCGACTGGGTACCAGCCGACCGCGGCTGGATTGCGGACCTGGCGCGAACCCTCAACGGGTCCG
CCGCAGATGTCCACCGTCGCTGTTAG

Upstream 100 bases:

>100_bases
ACACCACCGGCGCGCTGCCAGCCGTTGAGGTCGTGCAGTGCGGCGTCGACCTGCTCATCCGTTAACACAGCCATACCTCG
ACGGTATACCGTCACAGGTC

Downstream 100 bases:

>100_bases
GAAACCGACGGTGTGGTTGACGGTGGCCGCCGTCAACTTGGTTAGAACAACGTGACAAAACGTTAACTTGGGTTTGCATG
CCCGTAGCGATCACGATGGT

Product: putative mutator protein mutT2

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVGDDIALNGTT
TLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADRGWIADLARTLNGSAADVHRRC

Sequences:

>Translated_141_residues
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVGDDIALNGTT
TLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADRGWIADLARTLNGSAADVHRRC
>Mature_141_residues
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVGDDIALNGTT
TLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADRGWIADLARTLNGSAADVHRRC

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1788056, Length=116, Percent_Identity=39.6551724137931, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTT2_MYCTU (O06558)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842575
- PIR:   A70556
- RefSeq:   NP_215676.1
- RefSeq:   NP_335640.1
- ProteinModelPortal:   O06558
- SMR:   O06558
- EnsemblBacteria:   EBMYCT00000003515
- EnsemblBacteria:   EBMYCT00000072720
- GeneID:   888485
- GeneID:   924880
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1197
- KEGG:   mtu:Rv1160
- TIGR:   MT1197
- TubercuList:   Rv1160
- GeneTree:   EBGT00050000016320
- HOGENOM:   HBG741910
- OMA:   PRPLEDH
- ProtClustDB:   CLSK790988
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.-

Molecular weight: Translated: 15160; Mature: 15160

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLE
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEECCCHHHHHHHHHHHHHHCCE
VADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADR
EEHHHHCCCCCCCEEECCCEEEEEEEEEEECCCCCCCCCCEEEEEEECHHCCCCCCCCCC
GWIADLARTLNGSAADVHRRC
CHHHHHHHHHCCCCHHHCCCC
>Mature Secondary Structure
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLE
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEECCCHHHHHHHHHHHHHHCCE
VADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADR
EEHHHHCCCCCCCEEECCCEEEEEEEEEEECCCCCCCCCCEEEEEEECHHCCCCCCCCCC
GWIADLARTLNGSAADVHRRC
CHHHHHHHHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036