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The map label for this gene is uppS [C]

Identifier: 121637015

GI number: 121637015

Start: 1241894

End: 1242682

Strand: Direct

Name: uppS [C]

Synonym: BCG_1144

Alternate gene names: 121637015

Gene position: 1241894-1242682 (Clockwise)

Preceding gene: 121637013

Following gene: 121637016

Centisome position: 28.39

GC content: 65.15

Gene sequence:

>789_bases
GTGGAGATCATCCCGCCGCGGCTCAAAGAGCCGTTGTACCGGCTCTACGAGCTGCGCCTGCGGCAGGGCTTGGCCGCCTC
GAAATCCGACCTGCCCCGGCACATAGCCGTGCTGTGCGACGGCAACCGGCGATGGGCGCGCAGCGCGGGCTACGACGACG
TCAGCTACGGCTACCGGATGGGTGCGGCCAAGATCGCCGAAATGCTGCGGTGGTGCCACGAAGCCGGCATCGAACTGGCC
ACCGTCTATCTGCTGTCCACCGAAAACCTGCAGCGCGATCCCGACGAGCTTGCAGCACTCATCGAGATCATCACCGATGT
CGTGGAAGAGATCTGCGCACCGGCCAACCACTGGAGTGTGCGGACGGTCGGGGATCTGGGGTTGATCGGCGAGGAACCGG
CCCGGCGGCTGCGCGGTGCGGTGGAATCCACCCCGGAGGTGGCCTCGTTTCATGTCAACGTTGCTGTTGGCTACGGCGGG
CGCCGCGAGATCGTCGACGCTGTGCGCGCGTTGTTGAGCAAGGAACTCGCCAACGGGGCCACCGCGGAGGAACTCGTCGA
CGCGGTGACCGTCGAGGGTATCTCGGAAAACCTGTACACCTCAGGCCAACCCGACCCCGATTTGGTGATACGCACCTCCG
GCGAGCAACGCTTGTCCGGGTTCTTGCTGTGGCAAAGCGCCTACTCGGAGATGTGGTTCACCGAGGCGCACTGGCCGGCG
TTTCGCCACGTCGATTTTCTACGCGCGCTGCGTGACTACAGTGCGAGGCATCGCCGCTACGGCAGGTGA

Upstream 100 bases:

>100_bases
GCCTCGTCTTGTGCTTGCCGGTGGGTGTCGTCGAACACAGTAGTCGGGCCAGGTAGCGGACATCTGACTCGACGTCTGGG
TCACAGTAGTCTGGGTATCT

Downstream 100 bases:

>100_bases
ATCCGGCGCAGGACGCCTATGTTGCGCTGTTCGGCTGCCTGCGCAGAGTGCACATTAGCCGGCTCGTCATGCTGTGCAAT
CTGCCCAGGTGAAACCCGGT

Product: Short (C15) chain Z-isoprenyl diphosphate synthase

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELA
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRRYGR

Sequences:

>Translated_262_residues
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELA
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRRYGR
>Mature_262_residues
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELA
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRRYGR

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily

Homologues:

Organism=Homo sapiens, GI45580738, Length=234, Percent_Identity=34.6153846153846, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI45580742, Length=234, Percent_Identity=34.6153846153846, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=34.1991341991342, Blast_Score=134, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71993029, Length=233, Percent_Identity=28.755364806867, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=33.0275229357798, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=25.4545454545455, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18857969, Length=232, Percent_Identity=34.4827586206897, Blast_Score=133, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZFPP_MYCBO (Q7U0P8)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854770.1
- ProteinModelPortal:   Q7U0P8
- SMR:   Q7U0P8
- EnsemblBacteria:   EBMYCT00000014516
- GeneID:   1090431
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1115
- GeneTree:   EBGT00050000016292
- HOGENOM:   HBG627837
- OMA:   HLYTSGQ
- ProtClustDB:   CLSK790942
- BioCyc:   MBOV233413:MB1115-MONOMER
- BRENDA:   2.5.1.68
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.68

Molecular weight: Translated: 29480; Mature: 29480

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 40-40

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCHHHHHHH
GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA
EECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCH
FRHVDFLRALRDYSARHRRYGR
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCHHHHHHH
GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA
EECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCH
FRHVDFLRALRDYSARHRRYGR
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972