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The map label for this gene is eno [H]

Identifier: 121636952

GI number: 121636952

Start: 1175049

End: 1176338

Strand: Direct

Name: eno [H]

Synonym: BCG_1080

Alternate gene names: 121636952

Gene position: 1175049-1176338 (Clockwise)

Preceding gene: 121636951

Following gene: 121636953

Centisome position: 26.86

GC content: 66.82

Gene sequence:

>1290_bases
GTGCCGATTATCGAGCAGGTTGGGGCCCGAGAGATCCTCGATTCCCGCGGCAACCCGACGGTGGAGGTCGAGGTGGCGCT
TATCGACGGGACATTCGCCCGGGCCGCGGTGCCGTCGGGCGCCTCGACCGGGGAGCACGAGGCCGTCGAGTTGCGCGACG
GCGGCGATCGCTACGGCGGCAAAGGCGTGCAAAAAGCCGTGCAGGCTGTTCTTGATGAGATCGGCCCGGCCGTCATCGGA
CTCAACGCCGACGACCAGCGATTGGTCGACCAGGCGCTGGTGGACCTAGACGGCACCCCCGACAAGTCCCGGCTGGGCGG
CAACGCGATCTTGGGTGTCTCGCTCGCTGTTGCCAAGGCGGCGGCGGATTCGGCGGAGCTGCCGTTGTTCCGTTATGTCG
GGGGGCCAAACGCGCACATTCTGCCGGTACCGATGATGAACATCCTCAACGGCGGCGCACACGCCGATACCGCTGTCGAC
ATTCAAGAGTTCATGGTGGCGCCAATTGGCGCGCCCAGCTTCGTCGAGGCGTTGCGCTGGGGCGCTGAGGTGTACCACGC
GCTCAAGTCGGTCCTGAAAAAGGAGGGGCTGTCCACCGGCCTGGGCGACGAAGGCGGCTTCGCCCCGGATGTGGCCGGCA
CCACCGCGGCGTTGGACCTGATCAGCCGGGCCATCGAGTCGGCGGGCTTGCGACCCGGCGCCGACGTGGCGCTGGCCCTG
GACGCGGCGGCCACCGAGTTCTTCACCGACGGCACCGGCTACGTCTTCGAGGGCACCACCCGTACCGCAGACCAGATGAC
CGAGTTCTACGCGGGCCTGCTCGGCGCCTACCCGCTGGTGTCGATCGAAGACCCACTGTCCGAAGACGATTGGGACGGCT
GGGCCGCGCTGACGGCCTCGATCGGTGACCGGGTGCAAATCGTCGGCGACGACATCTTTGTCACCAATCCCGAGCGGCTC
GAGGAGGGCATCGAACGGGGCGTGGCAAATGCGTTGCTGGTCAAGGTGAACCAGATCGGGACGTTGACCGAGACACTCGA
CGCGGTCACGCTGGCTCACCACGGCGGATACCGCACGATGATCAGTCACCGCAGTGGCGAGACGGAGGACACCATGATCG
CCGACCTCGCGGTGGCCATCGGCAGCGGGCAGATCAAGACGGGCGCGCCTGCTCGCAGTGAGCGCGTCGCAAAATACAAC
CAGCTGCTGCGGATCGAAGAGGCGCTTGGCGACGCGGCCCGCTACGCGGGCGACCTGGCATTTCCTCGGTTCGCGTGCGA
GACGAAATAG

Upstream 100 bases:

>100_bases
GTAGCAGGATGAACCGCTAACCCAGGCTTTACGCTAACAGCGGTCGGGGCCAGCCAACCCAAGACCGTCCGTGCAGCAGC
TACGACGCAAGGAGAACCCA

Downstream 100 bases:

>100_bases
GTACATGCCCGAAGCGAAACGGCCCGAATCGAAGCGCCGGTCGCCGGCATCGCGCCCGGGGAAGGCCGGCGACTCGGTTC
GGGGCGGTCGCGCCACCAAG

Product: phosphopyruvate hydratase

Products: NA

Alternate protein names: 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydratase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MPIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIG
LNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVD
IQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALAL
DAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERL
EEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYN
QLLRIEEALGDAARYAGDLAFPRFACETK

Sequences:

>Translated_429_residues
MPIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIG
LNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVD
IQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALAL
DAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERL
EEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYN
QLLRIEEALGDAARYAGDLAFPRFACETK
>Mature_428_residues
PIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGL
NADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDI
QEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALALD
AAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLE
EGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQ
LLRIEEALGDAARYAGDLAFPRFACETK

Specific function: Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis [H]

COG id: COG0148

COG function: function code G; Enolase

Gene ontology:

Cell location: Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the bacterial ce

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enolase family [H]

Homologues:

Organism=Homo sapiens, GI5803011, Length=428, Percent_Identity=53.9719626168224, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI301897477, Length=430, Percent_Identity=51.8604651162791, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI301897469, Length=430, Percent_Identity=51.8604651162791, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI4503571, Length=429, Percent_Identity=50.8158508158508, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI301897479, Length=428, Percent_Identity=47.6635514018692, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI169201331, Length=338, Percent_Identity=25.1479289940828, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI169201757, Length=338, Percent_Identity=25.1479289940828, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI239744207, Length=338, Percent_Identity=25.1479289940828, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1789141, Length=425, Percent_Identity=55.2941176470588, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17536383, Length=434, Percent_Identity=51.1520737327189, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71995829, Length=434, Percent_Identity=51.1520737327189, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI32563855, Length=190, Percent_Identity=50.5263157894737, Blast_Score=198, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6321693, Length=433, Percent_Identity=51.9630484988453, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6323985, Length=432, Percent_Identity=50.462962962963, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324974, Length=432, Percent_Identity=50.462962962963, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324969, Length=432, Percent_Identity=50.462962962963, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321968, Length=433, Percent_Identity=51.0392609699769, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24580918, Length=429, Percent_Identity=50.8158508158508, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24580916, Length=429, Percent_Identity=50.8158508158508, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24580920, Length=429, Percent_Identity=50.8158508158508, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24580914, Length=429, Percent_Identity=50.8158508158508, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281360527, Length=429, Percent_Identity=50.8158508158508, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI17137654, Length=429, Percent_Identity=50.8158508158508, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000941
- InterPro:   IPR020810
- InterPro:   IPR020809
- InterPro:   IPR020811 [H]

Pfam domain/function: PF00113 Enolase_C; PF03952 Enolase_N [H]

EC number: =4.2.1.11 [H]

Molecular weight: Translated: 44863; Mature: 44732

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00164 ENOLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGG
CCCHHHCCHHHHHHCCCCCEEEEEEEEECCCHHHHCCCCCCCCCCCCEEEECCCCCCCCC
KGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKA
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEHHHHHHHHH
AADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFVEALRW
HCCCCCCCEEEECCCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
GAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALAL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEE
DAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTAS
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHC
IGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTM
CCCEEEEEECCEEECCHHHHHHHHHHHHHHHHEEEHHHHCHHHHHHHHHHHHHCCCCHHH
ISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLA
HCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FPRFACETK
CCCCCCCCC
>Mature Secondary Structure 
PIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGG
CCHHHCCHHHHHHCCCCCEEEEEEEEECCCHHHHCCCCCCCCCCCCEEEECCCCCCCCC
KGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKA
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEHHHHHHHHH
AADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFVEALRW
HCCCCCCCEEEECCCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
GAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALAL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEE
DAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTAS
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHC
IGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTM
CCCEEEEEECCEEECCHHHHHHHHHHHHHHHHEEEHHHHCHHHHHHHHHHHHHCCCCHHH
ISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLA
HCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FPRFACETK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA