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The map label for this gene is purH

Identifier: 121636882

GI number: 121636882

Start: 1098682

End: 1100253

Strand: Direct

Name: purH

Synonym: BCG_1011

Alternate gene names: 121636882

Gene position: 1098682-1100253 (Clockwise)

Preceding gene: 121636881

Following gene: 121636883

Centisome position: 25.12

GC content: 66.79

Gene sequence:

>1572_bases
ATGAGCACCGACGACGGAAGACGGCCGATCCGCCGTGCGCTGATCAGCGTGTACGACAAGACCGGGCTGGTAGACCTGGC
ACAGGGCCTGAGCGCGGCCGGCGTCGAGATCATCTCGACTGGGTCAACGGCCAAGACCATTGCCGACACCGGGATTCCGG
TGACCCCCGTGGAGCAGCTGACCGGCTTTCCCGAGGTGCTCGATGGCCGGGTCAAGACACTGCACCCGCGAGTGCATGCC
GGGCTGCTGGCTGACCTGCGCAAGTCCGAGCACGCCGCGGCCCTCGAGCAACTCGGGATCGAGGCTTTCGAACTCGTTGT
AGTCAACTTGTATCCGTTCAGCCAGACCGTCGAATCCGGCGCCAGTGTCGACGACTGCGTCGAGCAGATTGATATCGGCG
GGCCGGCGATGGTGCGGGCCGCCGCCAAAAACCATCCCAGCGCGGCGGTGGTCACCGATCCGCTTGGGTACCATGGCGTG
CTTGCCGCACTGCGCGCCGGCGGATTCACCCTCGCCGAGCGCAAAAGGCTGGCGTCGTTAGCGTTTCAGCATATAGCCGA
GTACGACATCGCCGTCGCGAGCTGGATGCAACAGACCCTAGCGCCCGAACATCCTGTTGCCGCCTTTCCGCAGTGGTTCG
GCCGAAGCTGGCGCCGCGTGGCGATGCTGCGCTACGGCGAGAACCCGCACCAACAGGCCGCTCTCTACGGCGACCCCACC
GCCTGGCCGGGGCTGGCCCAGGCCGAGCAACTGCACGGAAAAGACATGTCCTACAACAACTTCACCGATGCGGACGCAGC
CTGGCGGGCCGCCTTCGACCACGAACAAACGTGCGTGGCGATCATCAAGCACGCCAACCCGTGCGGCATCGCAATCTCGT
CCGTTTCGGTCGCCGACGCGCATCGCAAGGCTCACGAATGCGATCCGCTGAGCGCCTACGGCGGGGTCATCGCCGCCAAT
ACCGAGGTCAGTGTCGAAATGGCCGAGTATGTGAGCACCATCTTCACCGAAGTCATCGTCGCGCCTGGCTACGCCCCCGG
GGCCCTCGATGTGCTGGCCCGCAAGAAGAACATCCGGGTGCTGGTAGCCGCCGAGCCACTGGCCGGTGGCAGCGAGTTGC
GTCCGATCAGCGGTGGACTGCTGATACAGCAGAGCGACCAGCTTGACGCGCACGGTGACAACCCGGCGAACTGGACCTTG
GCGACCGGGTCACCTGCGGACCCCGCGACGCTGACCGACCTGGTCTTCGCGTGGCGAGCCTGCCGTGCGGTCAAGTCGAA
CGCGATAGTGATAGCTGCCGACGGCGCCACCGTCGGCGTCGGGATGGGTCAGGTCAACCGTGTCGACGCCGCCCGGTTGG
CCGTCGAACGCGGCGGCGAGCGGGTTCGCGGCGCGGTGGCAGCCTCGGATGCGTTCTTCCCCTTTCCCGACGGCCTGGAA
ACGTTGGCCGCCGCGGGGGTCACCGCGGTCGTCCACCCCGGTGGCTCGGTGCGCGACGAGGAAGTGACCGAAGCGGCGGC
CAAGGCCGGTGTCACCCTATATCTCACCGGGGCGCGGCACTTCGCGCACTGA

Upstream 100 bases:

>100_bases
CCGAACGACGGCTGTTGGTAGCGGCGGTGGCCGCACTGGCCACCCACGGCGTGACGGTGGTCGGACGAACAGCGACGATG
GGACGAAAGGTAACCATAGG

Downstream 100 bases:

>100_bases
GGCCGCTGGCCGCGACAGTGAAATCCACGACGTGACACGCCGGAAACGCGTCGTGACATTCACTCTCGTGGCCAGAAGAA
AGACGGCGTCGTAGCGTGGA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHA
GLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGV
LAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPT
AWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAAN
TEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTL
ATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE
TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH

Sequences:

>Translated_523_residues
MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHA
GLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGV
LAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPT
AWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAAN
TEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTL
ATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE
TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
>Mature_522_residues
STDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAG
LLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVL
AALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPTA
WPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANT
EVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLA
TGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLET
LAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=485, Percent_Identity=33.8144329896907, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1790439, Length=532, Percent_Identity=44.3609022556391, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71985564, Length=476, Percent_Identity=34.0336134453782, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71985574, Length=307, Percent_Identity=25.0814332247557, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985556, Length=142, Percent_Identity=35.2112676056338, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323056, Length=479, Percent_Identity=34.0292275574113, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323768, Length=475, Percent_Identity=34.1052631578947, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24649832, Length=476, Percent_Identity=33.8235294117647, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_MYCBO (P67542)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854639.1
- ProteinModelPortal:   P67542
- SMR:   P67542
- EnsemblBacteria:   EBMYCT00000014492
- GeneID:   1093066
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0982
- GeneTree:   EBGT00050000017138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   MBOV233413:MB0982-MONOMER
- BRENDA:   2.1.2.3
- BRENDA:   3.5.4.10
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 55027; Mature: 54895

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQL
CCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCCCCHHHH
TGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESG
CCCHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHCC
ASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASL
CCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
AFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHCHHHHHHHHHHCCCCHHHCEEECCCCC
AWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADA
CCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCHHHH
HRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRV
HHHHCCCCCCHHHCCEEEECCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEE
LVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRA
EEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
CRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE
HHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHEECCCCCCCCCCHH
TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
HHHHCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCHHCCC
>Mature Secondary Structure 
STDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQL
CCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCCCCHHHH
TGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESG
CCCHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHCC
ASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASL
CCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
AFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHCHHHHHHHHHHCCCCHHHCEEECCCCC
AWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADA
CCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCHHHH
HRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRV
HHHHCCCCCCHHHCCEEEECCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEE
LVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRA
EEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
CRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE
HHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHEECCCCCCCCCCHH
TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
HHHHCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972