| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is hdhA [H]
Identifier: 121636850
GI number: 121636850
Start: 1064315
End: 1065106
Strand: Reverse
Name: hdhA [H]
Synonym: BCG_0979c
Alternate gene names: 121636850
Gene position: 1065106-1064315 (Counterclockwise)
Preceding gene: 121636854
Following gene: 121636849
Centisome position: 24.35
GC content: 67.68
Gene sequence:
>792_bases ATGATCCTGGATATGTTCCGTCTTGACGACAAGGTTGCCGTCATCACCGGCGGCGGCCGCGGCCTGGGAGCAGCCATCGC ATTGGCTTTCGCCCAGGCCGGCGCGGATGTCCTCATCGCTTCACGAACATCATCCGAGCTTGACGCTGTCGCCGAACAGA TCCGCGCTGCCGGCCGCCGCGCCCACACCGTTGCCGCCGATCTGGCCCATCCCGAGGTGACCGCGCAGCTGGCTGGTCAG GCCGTCGGAGCTTTCGGGAAGCTCGACATCGTCGTCAACAACGTTGGCGGCACCATGCCCAACACGCTGCTAAGCACCTC GACCAAGGACCTCGCGGACGCCTTCGCCTTCAACGTGGGCACCGCCCACGCGCTGACCGTCGCGGCGGTGCCGCTGATGC TGGAACACTCCGGCGGCGGCAGCGTGATCAACATCAGCTCCACCATGGGCCGGCTGGCGGCGCGGGGTTTCGCCGCCTAC GGCACCGCCAAGGCCGCACTGGCCCACTACACCCGGCTGGCGGCGCTGGACCTGTGCCCACGCGTCCGGGTCAATGCGAT CGCGCCGGGTTCCATCCTGACCTCGGCGCTGGAGGTGGTAGCCGCCAACGACGAGCTGCGTGCGCCGATGGAGCAGGCGA CACCACTGCGCCGGCTCGGTGACCCCGTCGACATTGCAGCTGCGGCAGTGTATTTGGCCTCTCCGGCGGGCAGCTTCCTG ACCGGCAAGACGTTGGAGGTCGACGGCGGACTCACCTTCCCCAATCTCGACCTTCCCATTCCGGACCTGTGA
Upstream 100 bases:
>100_bases GTGCATACACAGCAGGCACACCCCCAGGTTTCGGGAGCAGTCACAGGAAGCTGCAGCAAGCTTGTTACCGTTTCGGCCGA CAGCCGGAAAAGAGGGCGCC
Downstream 100 bases:
>100_bases ACCGATGATGCGCGAGCAGTCGCAGTCTGACCCCTACCGCTAAGGAGCCCGCCATGGCCATACCCGTCGTTCAATTGGGC ACCGGCAACGTTGGCGTGCA
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 263; Mature: 263
Protein sequence:
>263_residues MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQ AVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAY GTAKAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL TGKTLEVDGGLTFPNLDLPIPDL
Sequences:
>Translated_263_residues MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQ AVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAY GTAKAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL TGKTLEVDGGLTFPNLDLPIPDL >Mature_263_residues MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQ AVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAY GTAKAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL TGKTLEVDGGLTFPNLDLPIPDL
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI10190704, Length=267, Percent_Identity=35.5805243445693, Blast_Score=122, Evalue=3e-28, Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=33.0612244897959, Blast_Score=120, Evalue=9e-28, Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=29.811320754717, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=31.4516129032258, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=29.9180327868852, Blast_Score=101, Evalue=7e-22, Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=34.6491228070175, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=30.5019305019305, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=26, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=27.6422764227642, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI66933014, Length=257, Percent_Identity=29.5719844357977, Blast_Score=82, Evalue=7e-16, Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=8e-16, Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI40254986, Length=210, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI210032110, Length=238, Percent_Identity=24.3697478991597, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI4557649, Length=170, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI4504505, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI31542939, Length=222, Percent_Identity=26.5765765765766, Blast_Score=66, Evalue=2e-11, Organism=Homo sapiens, GI20149619, Length=227, Percent_Identity=27.7533039647577, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI4503301, Length=222, Percent_Identity=26.1261261261261, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=39.5161290322581, Blast_Score=150, Evalue=1e-37, Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=35.3174603174603, Blast_Score=133, Evalue=1e-32, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=34.1085271317829, Blast_Score=123, Evalue=2e-29, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=34.6456692913386, Blast_Score=123, Evalue=2e-29, Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=34.4, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=31.1740890688259, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=28.9156626506024, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=31.9502074688797, Blast_Score=84, Evalue=9e-18, Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=30.6772908366534, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1787526, Length=249, Percent_Identity=28.1124497991968, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=28.7937743190661, Blast_Score=71, Evalue=7e-14, Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=24.8031496062992, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1786701, Length=190, Percent_Identity=29.4736842105263, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1787891, Length=240, Percent_Identity=27.0833333333333, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=36.5019011406844, Blast_Score=129, Evalue=1e-30, Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=32.3886639676113, Blast_Score=117, Evalue=8e-27, Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=30.0751879699248, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17562910, Length=276, Percent_Identity=30.7971014492754, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=32.8063241106719, Blast_Score=111, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=30.3030303030303, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=31.5589353612167, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=30.4511278195489, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=31.4606741573034, Blast_Score=107, Evalue=9e-24, Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=33.0708661417323, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=31.4606741573034, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=31.6981132075472, Blast_Score=103, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=30.6818181818182, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=32.258064516129, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=28.4090909090909, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=31.7269076305221, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=31.0606060606061, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=30.5220883534137, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=30.6818181818182, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=29.2134831460674, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17508895, Length=204, Percent_Identity=30.3921568627451, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=28.6792452830189, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=29.7397769516729, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=25.7028112449799, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17568967, Length=171, Percent_Identity=34.5029239766082, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=24.7148288973384, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=28.1746031746032, Blast_Score=78, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=27.9527559055118, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17564282, Length=157, Percent_Identity=28.0254777070064, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI71997099, Length=228, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=30.078125, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17561272, Length=258, Percent_Identity=30.6201550387597, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=262, Percent_Identity=29.3893129770992, Blast_Score=76, Evalue=5e-15, Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=30.5263157894737, Blast_Score=71, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6323882, Length=249, Percent_Identity=26.5060240963855, Blast_Score=68, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6322226, Length=190, Percent_Identity=27.8947368421053, Blast_Score=62, Evalue=9e-11, Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=33.7301587301587, Blast_Score=121, Evalue=5e-28, Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=32.9411764705882, Blast_Score=121, Evalue=5e-28, Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=32.6612903225806, Blast_Score=121, Evalue=6e-28, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=33.7301587301587, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=33.1983805668016, Blast_Score=110, Evalue=9e-25, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=32.2448979591837, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI24644337, Length=246, Percent_Identity=35.7723577235772, Blast_Score=102, Evalue=4e-22, Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=28.9156626506024, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI21358495, Length=194, Percent_Identity=28.8659793814433, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI18859837, Length=173, Percent_Identity=34.1040462427746, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI17737361, Length=271, Percent_Identity=28.7822878228782, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI21357673, Length=218, Percent_Identity=27.9816513761468, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 26746; Mature: 26746
Theoretical pI: Translated: 5.60; Mature: 5.60
Prosite motif: PS01108 RIBOSOMAL_L24 ; PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR CEECCEECCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCH AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG HHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHCCC TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP CHHHHHHHHHEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL CCEEEEECCHHHHHHHHHHHCCCCHHCCCHHHCCHHHHCCCCHHHHHHHHHHCCCCCCCC TGKTLEVDGGLTFPNLDLPIPDL CCCEEEECCCCCCCCCCCCCCCC >Mature Secondary Structure MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR CEECCEECCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCH AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG HHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHCCC TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP CHHHHHHHHHEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL CCEEEEECCHHHHHHHHHHHCCCCHHCCCHHHCCHHHHCCCCHHHHHHHHHHCCCCCCCC TGKTLEVDGGLTFPNLDLPIPDL CCCEEEECCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]