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The map label for this gene is serC

Identifier: 121636807

GI number: 121636807

Start: 1011881

End: 1013011

Strand: Reverse

Name: serC

Synonym: BCG_0936c

Alternate gene names: 121636807

Gene position: 1013011-1011881 (Counterclockwise)

Preceding gene: 121636810

Following gene: 121636806

Centisome position: 23.16

GC content: 65.78

Gene sequence:

>1131_bases
ATGGCCGACCAGCTCACCCCCCACCTGGAAATTCCCACCGCCATCAAACCCCGCGACGGCCGCTTTGGGTCGGGCCCGTC
GAAGGTCCGGCTTGAGCAACTGCAAACGCTGACCACCACCGCAGCGGCATTGTTCGGCACGTCGCACCGACAGGCGCCGG
TCAAGAATCTGGTGGGCAGGGTTCGGTCAGGCCTGGCCGAGCTGTTCTCGTTGCCGGACGGCTATGAGGTGATACTGGGC
AATGGTGGTGCCACGGCGTTCTGGGATGCGGCCGCCTTCGGGCTGATTGACAAACGCTCACTGCACTTGACTTACGGCGA
GTTCAGCGCGAAGTTCGCTTCCGCCGTTTCCAAGAACCCGTTCGTCGGCGAGCCGATCATCATCACGTCGGATCCCGGCA
GTGCTCCGGAGCCGCAAACCGACCCGTCAGTCGATGTGATCGCCTGGGCCCACAACGAGACCTCGACCGGGGTCGCGGTT
GCGGTGCGCCGTCCGGAGGGCTCCGATGACGCCTTGGTCGTCATCGACGCCACCTCCGGTGCTGGCGGCCTACCGGTCGA
CATCGCCGAGACCGACGCCTACTACTTCGCACCGCAGAAGAACTTCGCCAGCGACGGCGGCCTGTGGCTGGCCATCATGA
GCCCGGCCGCCCTGAGCCGGATCGAGGCCATCGCCGCGACCGGTCGCTGGGTTCCTGATTTCCTGTCCCTGCCGATCGCG
GTCGAGAACAGCTTGAAGAACCAGACATACAACACACCGGCCATCGCCACGCTGGCGCTGCTGGCCGAACAGATCGACTG
GCTGGTGGGTAACGGTGGCTTGGACTGGGCGGTCAAACGCACCGCGGACTCGTCGCAGCGGTTGTACTCGTGGGCGCAAG
AGCGGCCCTACACCACGCCATTTGTCACCGACCCCGGGTTGCGGTCGCAGGTGGTGGGCACGATCGACTTCGTCGACGAC
GTCGACGCCGGGACCGTCGCGAAGATCCTGCGGGCTAACGGCATCGTCGACACCGAGCCGTATCGCAAACTGGGCCGAAA
CCAGCTGCGGGTCGCGATGTTCCCCGCGGTCGAGCCGGACGACGTCAGCGCCCTCACCGAGTGCGTCGACTGGGTGGTCG
AGCGGCTTTAG

Upstream 100 bases:

>100_bases
AGGGCTTGCATGTGAGCTTGTTCACACTACGCGCCTGTGCCGGCAGGCTTTCGTTCCGCTCGAGTCGCCGCGGTTCGGTA
CCCCTCACTACCCTGATGGC

Downstream 100 bases:

>100_bases
CGCTGCCTTAGTGCGGCTGTGACCGGGCATTCCGGTCACCAGCGCCATGCCGGCAAGACACCTCCGCGTGTCAACGAGGC
TAACGGCGTTTACCGCACTA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILG
NGGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAV
AVRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIA
VENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDFVDD
VDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL

Sequences:

>Translated_376_residues
MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILG
NGGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAV
AVRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIA
VENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDFVDD
VDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL
>Mature_375_residues
ADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILGN
GGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAVA
VRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIAV
ENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDFVDDV
DAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=378, Percent_Identity=24.6031746031746, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI10863955, Length=286, Percent_Identity=25.8741258741259, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356589, Length=356, Percent_Identity=23.5955056179775, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_MYCBO (P63515)

Other databases:

- EMBL:   BX248336
- RefSeq:   NP_854565.1
- ProteinModelPortal:   P63515
- SMR:   P63515
- EnsemblBacteria:   EBMYCT00000016396
- GeneID:   1092794
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0908c
- GeneTree:   EBGT00050000017386
- HOGENOM:   HBG292317
- OMA:   SHRAKVG
- ProtClustDB:   PRK03080
- BioCyc:   MBOV233413:MB0908C-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR022278
- InterPro:   IPR006272
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01366

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40234; Mature: 40102

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 50-50 BINDING 108-108 BINDING 154-154 BINDING 176-176 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNP
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCCCC
FVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAVAVRRPEGSDDALVVIDATSG
CCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEECCCC
AGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIA
CCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCHHHHHCCHH
VENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTP
HHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCC
FVTDPGLRSQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPD
CCCCCCCHHHHEEEEEHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCH
DVSALTECVDWVVERL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGR
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNP
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCCCC
FVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAVAVRRPEGSDDALVVIDATSG
CCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEECCCC
AGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIA
CCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCHHHHHCCHH
VENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTP
HHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCC
FVTDPGLRSQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPD
CCCCCCCHHHHEEEEEHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCH
DVSALTECVDWVVERL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972