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The map label for this gene is galK

Identifier: 121636539

GI number: 121636539

Start: 743602

End: 744693

Strand: Direct

Name: galK

Synonym: BCG_0666

Alternate gene names: 121636539

Gene position: 743602-744693 (Clockwise)

Preceding gene: 121636538

Following gene: 121636540

Centisome position: 17.0

GC content: 72.53

Gene sequence:

>1092_bases
ATGACGGTCAGCTACGGCGCACCCGGGCGGGTCAACCTGATCGGCGAACACACCGATTACAACCTGGGTTTCGCGCTGCC
GATTGCGTTGCCGCGGCGCACCGTTGTCACGTTCACCCCCGAGCACACCGGCGCGATCACCGCGCGCAGCGACCGCGCCG
ACGGCTCGGCGCGGATCCCGCTCGACACCACGCCGGGGCAGGTGACCGGCTGGGCAGCCTATGCGGCCGGGGCGATCTGG
GCGCTGCGGGGCGCCGGCCACCCGGTGCCCGGCGGGGCGATGTCGATCACCAGCGACGTCGAGATCGGGTCGGGGCTTTC
GTCGTCGGCGGCGCTGATCGGCGCGGTGCTGGGCGCGGTCGGCGCCGCCACCGGCACCCGCATCGACCGTCTCGAGCGGG
CCCGGCTCGCACAGCGAGCCGAGAACGACTACGTCGGTGCCCCAACGGGTTTGCTCGACCACCTGGCCGCGCTGTTCGGA
GCGCCGAAGACCGCGCTGCTGATCGACTTTCGCGACATCACCGTGCGCCCGGTGGCCTTCGACCCGGACGCCTGCGATGT
GGTGCTGCTGTTGATGGATTCTCGAGCCCGACACCGTCACGCCGGCGGGGAGTATGCGCTGCGCCGGGCGTCGTGTGAAC
GGGCGGCCGCCGATCTGGGGGTGTCCTCGTTGCGCGCTGTGCAGGATCGCGGGCTGGCGGCGCTGGGCGCGATCGCCGAT
CCGATCGACGCGCGCCGCGCCCGGCACGTGCTGACCGAGAATCAGCGGGTGCTGGATTTCGCGGCCGCACTGGCTGATTC
GGATTTCACCGCCGCCGGGCAGCTGCTGACCGCGTCGCATGAGTCCATGCGCGAGGACTTCGCCATCACCACCGAGCGGA
TCGATCTGATCGCCGAGAGCGCCGTACGGGCCGGTGCGCTGGGCGCCCGGATGACCGGGGGCGGCTTCGGGGGCGCCGTG
ATCGCACTGGTGCCTGCCGATAGGGCGCGCGACGTGGCCGACACGGTGCGACGGGCGGCGGTCACCGCCGGCTACGACGA
GCCGGCGGTGAGCCGGACCTATGCCGCGCCCGGCGCGGCCGAGTGCTGTTGA

Upstream 100 bases:

>100_bases
CCAAACTGAAATATCTGGCGGCCGCCGAGTCGGCGATGGACGCGTTCATCGCCGACGTTATCCCGGAGAGCGTGGCCGCC
CGGCTGCGCGAGCTGGGCCC

Downstream 100 bases:

>100_bases
GCGGGTTGGCGAAGCGTCATGTCCACAGTGAGCAGATCGGTGCGGGTCCGCCACTGCCCTTGACCTCGAAGCCGAACACC
GGCTACGAGACCGCTGCCGC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIW
ALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFG
APKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAV
IALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECC

Sequences:

>Translated_363_residues
MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIW
ALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFG
APKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAV
IALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECC
>Mature_362_residues
TVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIWA
LRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGA
PKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIADP
IDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVI
ALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=342, Percent_Identity=39.4736842105263, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1786972, Length=331, Percent_Identity=37.7643504531722, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71989053, Length=384, Percent_Identity=24.21875, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319494, Length=197, Percent_Identity=32.994923857868, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_MYCBO (Q7U1L7)

Other databases:

- EMBL:   BX248336
- RefSeq:   NP_854295.1
- ProteinModelPortal:   Q7U1L7
- SMR:   Q7U1L7
- EnsemblBacteria:   EBMYCT00000015434
- GeneID:   1091737
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0636
- GeneTree:   EBGT00050000016589
- HOGENOM:   HBG725121
- OMA:   YNDGFVM
- ProtClustDB:   PRK00555
- BioCyc:   MBOV233413:MB0636-MONOMER
- BRENDA:   2.7.1.6
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 37573; Mature: 37442

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIP
CEECCCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCEEEECCCCCCCCEECC
LDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAV
CCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
GAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAF
HCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCEEEEEEE
DPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
CCCHHHEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCC
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAES
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAA
HHHHCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
ECC
CCC
>Mature Secondary Structure 
TVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIP
EECCCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCEEEECCCCCCCCEECC
LDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAV
CCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
GAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAF
HCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCEEEEEEE
DPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
CCCHHHEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCC
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAES
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAA
HHHHCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
ECC
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972