Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 121636417

GI number: 121636417

Start: 620881

End: 621768

Strand: Direct

Name: proC [H]

Synonym: BCG_0542

Alternate gene names: 121636417

Gene position: 620881-621768 (Clockwise)

Preceding gene: 121636416

Following gene: 121636418

Centisome position: 14.19

GC content: 66.33

Gene sequence:

>888_bases
ATGCTTTTCGGCATGGCAAGGATCGCGATTATCGGCGGCGGCAGCATCGGTGAGGCATTGCTGTCGGGTCTGCTGCGGGC
GGGCCGGCAGGTCAAAGACCTGGTAGTGGCCGAGCGGATGCCCGATCGCGCCAACTACCTGGCGCAGACCTATTCGGTGT
TGGTGACGTCGGCGGCCGACGCGGTGGAGAACGCGACGTTCGTCGTCGTCGCGGTCAAACCAGCCGACGTCGAGCCGGTG
ATCGCGGATCTGGCGAACGCGACTGCGGCGGCCGAAAACGACAGTGCTGAGCAGGTGTTCGTCACCGTGGTAGCGGGCAT
CACGATCGCGTATTTCGAATCCAAGCTACCGGCCGGGACGCCAGTGGTGCGTGCGATGCCGAACGCGGCGGCATTGGTGG
GAGCGGGGGTTACAGCGCTGGCCAAAGGCCGCTTTGTCACCCCGCAACAGCTTGAGGAGGTCTCGGCCTTGTTCGACGCG
GTCGGCGGCGTGCTGACCGTTCCGGAATCGCAGTTGGACGCGGTGACCGCGGTGTCCGGCTCGGGTCCGGCCTATTTCTT
TCTGCTGGTCGAGGCCCTGGTGGATGCCGGAGTCGGGGTGGGCTTGAGCCGTCAGGTGGCCACCGATCTCGCCGCGCAGA
CAATGGCTGGCTCAGCGGCGATGCTGCTGGAGCGGATGGACCAAGACCAGGGTGGCGCCAATGGCGAGCTGATGGGGCTG
CGCGTGGACCTTACCGCATCACGGCTGCGCGCCGCGGTTACCTCGCCGGGCGGTACGACCGCCGCTGCGCTGCGGGAACT
CGAACGCGGCGGGTTTCGGATGGCTGTCGACGCGGCGGTTCAAGCCGCCAAAAGCCGCTCTGAGCAGCTCAGAATTACAC
CGGAATGA

Upstream 100 bases:

>100_bases
GGACCACATCGTCGTCGACCGGTTGGGCCGCATCGTGGTGCAGACGCGCCAACTGGCGATGGTGCCTGCCCAGTAGCACG
GATCGGCCGAGCTGTCTGCG

Downstream 100 bases:

>100_bases
TTCACGAATTTTGAACTGATTATCCCTCACCAGTACCAGTAACCCCACTAGTCCCGCTATTCTCCTCTTTGTAAGCGCGT
GTGGGTGCCAGCGGAGGGGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPV
IADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGANGELMGL
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE

Sequences:

>Translated_295_residues
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPV
IADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGANGELMGL
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
>Mature_295_residues
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPV
IADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGANGELMGL
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=285, Percent_Identity=31.5789473684211, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI21361454, Length=291, Percent_Identity=33.6769759450172, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI24797097, Length=294, Percent_Identity=34.0136054421769, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI24797095, Length=294, Percent_Identity=34.0136054421769, Blast_Score=118, Evalue=5e-27,
Organism=Escherichia coli, GI1786585, Length=286, Percent_Identity=34.2657342657343, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=284, Percent_Identity=35.2112676056338, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=294, Percent_Identity=30.2721088435374, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=310, Percent_Identity=27.0967741935484, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21358587, Length=291, Percent_Identity=36.426116838488, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24648116, Length=295, Percent_Identity=33.2203389830508, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24647700, Length=185, Percent_Identity=41.6216216216216, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30158; Mature: 30158

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAAD
CCCCEEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGT
HHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSG
CHHHHCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHEEEECC
SGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGANGELMGL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEE
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
EEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAAD
CCCCEEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGT
HHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSG
CHHHHCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHEEEECC
SGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGANGELMGL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEE
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
EEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]