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The map label for this gene is hbhA

Identifier: 121636391

GI number: 121636391

Start: 596612

End: 597211

Strand: Direct

Name: hbhA

Synonym: BCG_0516

Alternate gene names: 121636391

Gene position: 596612-597211 (Clockwise)

Preceding gene: 121636390

Following gene: 121636392

Centisome position: 13.64

GC content: 66.17

Gene sequence:

>600_bases
ATGGCTGAAAACTCGAACATTGATGACATCAAGGCTCCGTTGCTTGCCGCGCTTGGAGCGGCCGACCTGGCCTTGGCCAC
TGTCAACGAGTTGATCACGAACCTGCGTGAGCGTGCGGAGGAGACTCGTACGGACACCCGCAGCCGGGTCGAGGAGAGCC
GTGCTCGCCTGACCAAGCTGCAGGAAGATCTGCCCGAGCAGCTCACCGAGCTGCGTGAGAAGTTCACCGCCGAGGAGCTG
CGTAAGGCCGCCGAGGGCTACCTCGAGGCCGCGACTAGCCGGTACAACGAGCTGGTCGAGCGCGGTGAGGCCGCTCTAGA
GCGGCTGCGCAGCCAGCAGAGCTTCGAGGAAGTGTCGGCGCGCGCCGAAGGCTACGTGGACCAGGCGGTGGAGTTGACCC
AGGAGGCGTTGGGTACGGTCGCATCGCAGACCCGCGCGGTCGGTGAGCGTGCCGCCAAGCTGGTCGGCATCGAGCTGCCT
AAGAAGGCTGCTCCGGCCAAGAAGGCCGCTCCGGCCAAGAAGGCCGCTCCGGCCAAGAAGGCGGCGGCCAAGAAGGCGCC
CGCGAAGAAGGCGGCGGCCAAGAAGGTCACCCAGAAGTAG

Upstream 100 bases:

>100_bases
CTTGACTAGTCCTCCCTGGAGGAGCCGACGCTTGCCCCAACGTCCAGACCAAAGATGTAAGAACGCCGATATCAGAAAAT
AGTTAATGAAAGGAATACCC

Downstream 100 bases:

>100_bases
TCGGGCTCCGAATCACCATCGACTCCGAGTCGCCCACGGGGCGACTCGGAGTCGACGTGTTGGATGCAAACCGCATAGTC
TGAATGCGTGAGCCACCTCG

Product: Heparin binding hemagglutinin hbhA

Products: NA

Alternate protein names: Adhesin

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEEL
RKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELP
KKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK

Sequences:

>Translated_199_residues
MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEEL
RKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELP
KKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK
>Mature_198_residues
AENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELR
KAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPK
KAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK

Specific function: Required for extrapulmonary dissemination. Mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. Promotes hemagglutination of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell surface

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.leprae hbhA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HBHA_MYCBO (P0C2T3)

Other databases:

- EMBL:   BX248335
- RefSeq:   NP_854148.1
- EnsemblBacteria:   EBMYCT00000017611
- GeneID:   1091523
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0485
- GeneTree:   EBGT00050000014974
- HOGENOM:   HBG569842
- OMA:   VGEQAAK
- ProtClustDB:   CLSK790542
- GO:   GO:0009405
- InterPro:   IPR020340
- ProDom:   PD082580

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 21535; Mature: 21403

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHCCHHHH
AAAKKAPAKKAAAKKVTQK
HHHHHCHHHHHHHHHHCCC
>Mature Secondary Structure 
AENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHCCHHHH
AAAKKAPAKKAAAKKVTQK
HHHHHCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972; 11449276