Click here to switch to the map view.

The map label for this gene is gmhB

Identifier: 121636027

GI number: 121636027

Start: 167685

End: 168257

Strand: Direct

Name: gmhB

Synonym: BCG_0147

Alternate gene names: 121636027

Gene position: 167685-168257 (Clockwise)

Preceding gene: 121636026

Following gene: 121636028

Centisome position: 3.83

GC content: 61.43

Gene sequence:

>573_bases
ATGGTCGCGGAACGTGCGGGACACCAATGGTGTCTCTTCCTCGATAGAGACGGGGTCATCAATCGACAAGTGGTCGGCGA
CTACGTACGGAACTGGCGGCAGTTTGAATGGTTGCCCGGGGCGGCGCGGGCGTTGAAGAAGCTACGGGCATGGGCTCCGT
ACATCGTTGTCGTGACAAACCAGCAGGGCGTGGGTGCCGGATTGATGAGCGCCGTCGACGTGATGGTGATACATCGGCAC
CTCCAAATGCAGCTTGCATCCGATGGCGTGCTGATAGATGGATTTCAGGTTTGCCCGCACCACCGTTCGCAGCGGTGTGG
CTGCCGTAAGCCGAGACCGGGTCTGGTCCTCGACTGGCTCAGACGACACCCCGACAGTGAGCCATTGCTGAGCATCGTGG
TTGGGGACAGCCTCAGCGATCTTGAATTGGCACACAACGTCGCCGCTGCTGCCGGTGCATGTGCCAGTGTCCAGATAGGG
GGCGCCAGTTCTGGCGGTGTCGCTGACGCGTCATTTGACTCGCTCTGGGAGTTCGCTGTCGCAGTCGGACATGCGCGGGG
GGAGCGGGGCTAA

Upstream 100 bases:

>100_bases
TCTCACATCGTTTTTATTCATGCGATCTCCGAACATGTCGAACACGCGCTTTTCGCGCCTCGCCAATAGGAAAGCCGATC
CTTACGCGGCCATTCGAAAG

Downstream 100 bases:

>100_bases
TGGCGATCTTGCGCGGGCGAGCGCCGTTGCGGCTCGGACTCGGCGGTGGCGGGACAGACGTGGAACCGTACTCGAGCCAG
TTTGGCGGACGAATTCTTAG

Product: putative dehydratase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRH
LQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWLRRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIG
GASSGGVADASFDSLWEFAVAVGHARGERG

Sequences:

>Translated_190_residues
MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRH
LQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWLRRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIG
GASSGGVADASFDSLWEFAVAVGHARGERG
>Mature_190_residues
MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRH
LQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWLRRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIG
GASSGGVADASFDSLWEFAVAVGHARGERG

Specific function: Converts the D-glycero-alpha-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family

Homologues:

Organism=Escherichia coli, GI1786399, Length=181, Percent_Identity=33.7016574585635, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082027, Length=140, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHB_MYCBO (Q7U2U1)

Other databases:

- EMBL:   BX248334
- RefSeq:   NP_853785.1
- ProteinModelPortal:   Q7U2U1
- SMR:   Q7U2U1
- EnsemblBacteria:   EBMYCT00000015760
- GeneID:   1090799
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0118
- GeneTree:   EBGT00050000016043
- HOGENOM:   HBG613347
- OMA:   GVINHDS
- ProtClustDB:   CLSK790274
- BioCyc:   MBOV233413:MB0118-MONOMER
- GO:   GO:0005737
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR006543
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01656

Pfam domain/function: SSF56784 SSF56784

EC number: NA

Molecular weight: Translated: 20611; Mature: 20611

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTN
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEC
QQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECEECCCCCCCCCCCCCCCCCCHHHHHH
RRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIGGASSGGVADASFDSLWEFAV
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHH
AVGHARGERG
HHHHCCCCCC
>Mature Secondary Structure
MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARALKKLRAWAPYIVVVTN
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEC
QQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHRSQRCGCRKPRPGLVLDWL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECEECCCCCCCCCCCCCCCCCCHHHHHH
RRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIGGASSGGVADASFDSLWEFAV
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHH
AVGHARGERG
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972