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The map label for this gene is sigMa_2 [H]

Identifier: 121635897

GI number: 121635897

Start: 18322

End: 18912

Strand: Direct

Name: sigMa_2 [H]

Synonym: BCG_0016

Alternate gene names: 121635897

Gene position: 18322-18912 (Clockwise)

Preceding gene: 121635896

Following gene: 121635898

Centisome position: 0.42

GC content: 70.56

Gene sequence:

>591_bases
ATGCCGCCACCGATTGGTTACTGTCCGGCCGTGGGTTTCGGGGGCCGTCACGAGCGCAGCGACGCCGAGCTGCTGGCCGC
CCATGTCGCCGGCGACCGGTACGCCTTCGATCAGTTGTTCCGCCGTCATCACCGCCAGCTACACCGGCTCGCGCGGCTCA
CCAGCCGGACCTCCGAGGACGCCGACGATGCGCTGCAAGACGCGATGCTGTCAGCGCACCGCGGCGCCGGCTCGTTCCGG
TACGATGCCGCCGTCAGCAGTTGGTTGCACCGCATCGTGGTCAACGCTTGCCTGGACCGGCTGCGTCGGGCCAAAGCCCA
TCCGACCGCCCCTCTAGAAGATGTCTATCCGGTCGCGGACCGGACCGCGCAGGTCGAGACCGCGATCGCGGTGCAGCGGG
CACTGATGCGGCTGCCCGTCGAGCAGCGGGCCGCGGTGGTCGCCGTGGACATGCAGGGCTATTCGATCGCCGACACCGCC
CGGATGCTGGGCGTGGCCGAGGGCACCGTCAAGAGCCGCTGCGCCCGGGCGCGGGCCCGCCTAGCGCGGCTGCTGGGCTA
TCTCAACACCGGGGTGAACATCCGGCGCTGA

Upstream 100 bases:

>100_bases
TTGGGAACCACCGACGGAAAGAGTCAAGCCGACATCTCGGAGATCACGATTTACGCCGCGTCCTGACCGGGCCGGGCACG
GCCAGCCAGGGTGAAGTGCT

Downstream 100 bases:

>100_bases
CCCCGTTGCCGGTCCGTCGTAGCATCGATCCACGGGCTCGCCGCTACCCCACATCTGGCTATTGCCACCGGGCATGACGG
ACACTGGGGCCGATGAGTGC

Product: RNA polymerase sigma factor SigM

Products: NA

Alternate protein names: Sigma-24 [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAMLSAHRGAGSFR
YDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTA
RMLGVAEGTVKSRCARARARLARLLGYLNTGVNIRR

Sequences:

>Translated_196_residues
MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAMLSAHRGAGSFR
YDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTA
RMLGVAEGTVKSRCARARARLARLLGYLNTGVNIRR
>Mature_195_residues
PPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAMLSAHRGAGSFRY
DAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTAR
MLGVAEGTVKSRCARARARLARLLGYLNTGVNIRR

Specific function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in heat shock and oxidative stress response; it is believed to control protein processing

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sigma-70 factor family. ECF subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788926, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: <10 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014284
- InterPro:   IPR014293
- InterPro:   IPR000838
- InterPro:   IPR007627
- InterPro:   IPR013249
- InterPro:   IPR013325
- InterPro:   IPR013324 [H]

Pfam domain/function: PF04542 Sigma70_r2; PF08281 Sigma70_r4_2 [H]

EC number: NA

Molecular weight: Translated: 21649; Mature: 21518

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSED
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVAD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTARMLGVAEGTVKSRCARARAR
HHHHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LARLLGYLNTGVNIRR
HHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSED
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVAD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTARMLGVAEGTVKSRCARARAR
HHHHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LARLLGYLNTGVNIRR
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]