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The map label for this gene is lysC [H]

Identifier: 121611838

GI number: 121611838

Start: 5459857

End: 5461125

Strand: Direct

Name: lysC [H]

Synonym: Veis_4940

Alternate gene names: 121611838

Gene position: 5459857-5461125 (Clockwise)

Preceding gene: 121611837

Following gene: 121611842

Centisome position: 98.08

GC content: 63.12

Gene sequence:

>1269_bases
ATGGCATTGATCGTTCACAAATACGGCGGCACCTCGATGGGCTCACCCGAGCGCATCCGCTGCGTTGCCAAGCGCGTCGC
CAAATGGGCCCGCGCAGGCCACCAGATGGTGGTGGTGCCCAGCGCCATGAGCGGCGAAACCAACCGCCTGCTCGCGCTGG
CCAAGGAACTCGCCCCCGCCCGCGCCACCGATGCCTACCACCGCGAACTCGACATGCTGGCCGCCACCGGCGAGCAGGCT
TCATCGGCATTGCTGGCCATTGCGCTGCAGGCCGAGGGCCTGGGCTCGGTCAGCTACGCCGGCTGGCAGTTGCCGATCCG
CACCGACAGCAGCTACACCAAGGCCCGCATCGAATCCATCGACGACCAGCGTGTGCGTGCCGATCTGGCCCATGGCAAGG
TGGTCATCGTGACCGGCTTTCAAGGCATCGACGACGAAGGCAACATCACCACGCTCGGCCGTGGCGGCTCGGACACCTCG
GCCGTGGCCGTGGCGGCGGCGATGAAAGCCCACGAATGCCTGATCTACACCGACGTCGACGGCGTATACACCACCGACCC
GCGCGTGGTGCCCCAGGCCCGGCGCCTGCAGACGGTGAGCTTCGAGGAAATGCTTGAAATGGCCAGCCTGGGCAGCAAGG
TGCTGCAAATCCGCTCGGTCGAATTCGCCGGCAAGTACAGGGTCCGGCTGCGCGTGCTGTCGAGCTTCACCCCCTGGGAC
ATGGACATTGACGAAGAAGCCCGCTCCGGCACGCTGATCACTTTCGAGGAGGACGAAAAAATGGAACAAGCCGTCGTATC
CGGCATCGCTTTCAACCGCGACGAAGCCAAGCTCTCCGTGCTCGGCGTGCCCGACAAGCCCGGCATCGCCTACCTGATCC
TGGGCGCCGTGGCCGATGCCAACATCGATGTCGACATGATCATCCAGAACCTGAGCAAGGATGGCAAAACCGACTTCAGC
TTCACCGTGCACCGCAACGACTACGCCCGCGCCATCGATCTGATCAAGGAAAAAGTGCTCCCCGTGCTGGGCGCGCACGA
AGTGGTTGGCGACACCAACATCTGCAAAGTCAGCATCGTCGGCATCGGCATGCGCAGCCATGTGGGCGTGGCCAGCAAGA
TGTTTCGCGTGCTCAGCGAAGAAAGCATCAACATCCAGATGATCTCCACATCCGAAATCAAGACCTCGGTCGTGATCGAC
GAAAAATACATGGAGCTGGCCGTGCGCAGCCTGCACCAAGCCTTCGGGCTGGACCAGGAAGCGGCCTGA

Upstream 100 bases:

>100_bases
CAACGCACGAAAGGCAGGAACCACGGCGGCGCGCCCACACAGGGCAAGGGCAAGGACGCCAGCGCCGTGGTTTCGGATTC
GTCATCCCGCAAAAACTCCA

Downstream 100 bases:

>100_bases
ACCATGAAATAAGGCATAATCGCGCCACTGGAAACGTGACCGAGTGGCCGAAGGTGCTCCCCTGCTAAGGGAGTATGGGG
TGTAGAGCCTCATCGAGGGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MALIVHKYGGTSMGSPERIRCVAKRVAKWARAGHQMVVVPSAMSGETNRLLALAKELAPARATDAYHRELDMLAATGEQA
SSALLAIALQAEGLGSVSYAGWQLPIRTDSSYTKARIESIDDQRVRADLAHGKVVIVTGFQGIDDEGNITTLGRGGSDTS
AVAVAAAMKAHECLIYTDVDGVYTTDPRVVPQARRLQTVSFEEMLEMASLGSKVLQIRSVEFAGKYRVRLRVLSSFTPWD
MDIDEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKLSVLGVPDKPGIAYLILGAVADANIDVDMIIQNLSKDGKTDFS
FTVHRNDYARAIDLIKEKVLPVLGAHEVVGDTNICKVSIVGIGMRSHVGVASKMFRVLSEESINIQMISTSEIKTSVVID
EKYMELAVRSLHQAFGLDQEAA

Sequences:

>Translated_422_residues
MALIVHKYGGTSMGSPERIRCVAKRVAKWARAGHQMVVVPSAMSGETNRLLALAKELAPARATDAYHRELDMLAATGEQA
SSALLAIALQAEGLGSVSYAGWQLPIRTDSSYTKARIESIDDQRVRADLAHGKVVIVTGFQGIDDEGNITTLGRGGSDTS
AVAVAAAMKAHECLIYTDVDGVYTTDPRVVPQARRLQTVSFEEMLEMASLGSKVLQIRSVEFAGKYRVRLRVLSSFTPWD
MDIDEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKLSVLGVPDKPGIAYLILGAVADANIDVDMIIQNLSKDGKTDFS
FTVHRNDYARAIDLIKEKVLPVLGAHEVVGDTNICKVSIVGIGMRSHVGVASKMFRVLSEESINIQMISTSEIKTSVVID
EKYMELAVRSLHQAFGLDQEAA
>Mature_421_residues
ALIVHKYGGTSMGSPERIRCVAKRVAKWARAGHQMVVVPSAMSGETNRLLALAKELAPARATDAYHRELDMLAATGEQAS
SALLAIALQAEGLGSVSYAGWQLPIRTDSSYTKARIESIDDQRVRADLAHGKVVIVTGFQGIDDEGNITTLGRGGSDTSA
VAVAAAMKAHECLIYTDVDGVYTTDPRVVPQARRLQTVSFEEMLEMASLGSKVLQIRSVEFAGKYRVRLRVLSSFTPWDM
DIDEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKLSVLGVPDKPGIAYLILGAVADANIDVDMIIQNLSKDGKTDFSF
TVHRNDYARAIDLIKEKVLPVLGAHEVVGDTNICKVSIVGIGMRSHVGVASKMFRVLSEESINIQMISTSEIKTSVVIDE
KYMELAVRSLHQAFGLDQEAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=363, Percent_Identity=32.7823691460055, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790455, Length=384, Percent_Identity=27.0833333333333, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790376, Length=285, Percent_Identity=27.719298245614, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=391, Percent_Identity=24.8081841432225, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45804; Mature: 45673

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSPERIRCVAKRVAKWARAGHQMVVVPSAMSGETNRLLALAKELAPA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
RATDAYHRELDMLAATGEQASSALLAIALQAEGLGSVSYAGWQLPIRTDSSYTKARIESI
CCCHHHHHHHHHHHHCCCHHCCEEEEEEEECCCCCCEEECCEEEEEECCCCHHHHHHHCC
DDQRVRADLAHGKVVIVTGFQGIDDEGNITTLGRGGSDTSAVAVAAAMKAHECLIYTDVD
CHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEEEECC
GVYTTDPRVVPQARRLQTVSFEEMLEMASLGSKVLQIRSVEFAGKYRVRLRVLSSFTPWD
CEEECCCCCCCCHHHHEECCHHHHHHHHHHCHHHEEEEEEEECCCEEEEEEEECCCCCCC
MDIDEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKLSVLGVPDKPGIAYLILGAVADA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEEEEEEEECCCC
NIDVDMIIQNLSKDGKTDFSFTVHRNDYARAIDLIKEKVLPVLGAHEVVGDTNICKVSIV
CCCHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEE
GIGMRSHVGVASKMFRVLSEESINIQMISTSEIKTSVVIDEKYMELAVRSLHQAFGLDQE
EECHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
AA
CC
>Mature Secondary Structure 
ALIVHKYGGTSMGSPERIRCVAKRVAKWARAGHQMVVVPSAMSGETNRLLALAKELAPA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
RATDAYHRELDMLAATGEQASSALLAIALQAEGLGSVSYAGWQLPIRTDSSYTKARIESI
CCCHHHHHHHHHHHHCCCHHCCEEEEEEEECCCCCCEEECCEEEEEECCCCHHHHHHHCC
DDQRVRADLAHGKVVIVTGFQGIDDEGNITTLGRGGSDTSAVAVAAAMKAHECLIYTDVD
CHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEEEECC
GVYTTDPRVVPQARRLQTVSFEEMLEMASLGSKVLQIRSVEFAGKYRVRLRVLSSFTPWD
CEEECCCCCCCCHHHHEECCHHHHHHHHHHCHHHEEEEEEEECCCEEEEEEEECCCCCCC
MDIDEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKLSVLGVPDKPGIAYLILGAVADA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEEEEEEEECCCC
NIDVDMIIQNLSKDGKTDFSFTVHRNDYARAIDLIKEKVLPVLGAHEVVGDTNICKVSIV
CCCHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEE
GIGMRSHVGVASKMFRVLSEESINIQMISTSEIKTSVVIDEKYMELAVRSLHQAFGLDQE
EECHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]