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The map label for this gene is hmuU [H]

Identifier: 121611679

GI number: 121611679

Start: 5270699

End: 5271622

Strand: Direct

Name: hmuU [H]

Synonym: Veis_4775

Alternate gene names: 121611679

Gene position: 5270699-5271622 (Clockwise)

Preceding gene: 121611678

Following gene: 121611680

Centisome position: 94.68

GC content: 75.65

Gene sequence:

>924_bases
GTGGGCAGCACCGGTTGGGACAGCCTGCTGCACCTCGGCGACGACCCCGTGGCCTGGCAGATCCTGTGGAGCATCCGCCT
GCCGCGCACGCTCGGCGCGTGGCTGGCCGGGGCGCTGCTGGGCCTGGCCGGCGCCGTCGCGCAGGGGCTGTTTCGCAACC
CGCTGGCCGACCCGTACCTGCTCGGCAGCGCCTCGGGCGCGGCGCTGGGCGCGGCCGTGGCGCTGGCGCTGCTGGGCGTA
TCCCCGGTGGCGCCGCAGTGGCTGGCGCGCATCGGCATCACCGGCATGGCCTTCGTCGGGGCTGCCGGGGCCGTGCTGCT
GACGCTGCTGCTGGCCCGGGGCGTGCAGCACCCGCTGCGCCTGCTGCTGGCCGGCGTGATCGTCGGCGTGGTGCTGGGGG
CGCTGCGCGAATTGCTGCAGTTGGCATCGCCCGACATCCTGCAAGCCATGCAGGCGTTCACGCTGGGCAGCACGGCCTTC
GTCGGCGCGCCGGCCTGCGTGCTGATGGCGCTGGCCTGGGTCTCGTGCGCGGCGCTGGCCTGGATGCTGGCGCGCGCGCT
CGACGGCCTGACGCTGGGCGAGGCCACGGCCGCCAGCCTGGGCCTGCCGCTGCTGCCGATGCGCGCCGGGCTGGTGGCTG
CGCTGGCGCTGGCCACCGGCACGGCGGTGGCGCAGACCGGGCTGATCGCCTTCGTCGGGCTGGCGGCGCCGCACCTGCTG
CGCTCCATCGTGCGCGTGACGCACGCGCGGCATATCCTGCTGTCCAGCCTGATGGGCGCCGTGCTGCTGCTGGCCGCCGA
CATCCTGGCGCGCTGGCTGCTGGCGCCGCAGGAACTGCCGGTGGGCGTGCTCACGGCGGCGCTGGGCGGCAGCTACCTGC
TGTGGCTGATGCACCGGCGCAGCACGCAAGGCGCAGGGCCATGA

Upstream 100 bases:

>100_bases
GGGTGCCACCCCGCCGCCGGGCGCAACCCACCAGCGCGCGCTGCGCTGTGGCGCCTGGCTGCTGCTGGCCAGCGCGCTGC
TGGCGCTGTGCGGCGCCAGC

Downstream 100 bases:

>100_bases
AGAACCCGATCGCCCTTGGCGCCAGCCAACTGAGCGCCCGCATCGGCGCCCGGCAGATCCTGCACGGCATCGACCTGCAA
CTGCCCGCCGGGCGCTGGAC

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGSTGWDSLLHLGDDPVAWQILWSIRLPRTLGAWLAGALLGLAGAVAQGLFRNPLADPYLLGSASGAALGAAVALALLGV
SPVAPQWLARIGITGMAFVGAAGAVLLTLLLARGVQHPLRLLLAGVIVGVVLGALRELLQLASPDILQAMQAFTLGSTAF
VGAPACVLMALAWVSCAALAWMLARALDGLTLGEATAASLGLPLLPMRAGLVAALALATGTAVAQTGLIAFVGLAAPHLL
RSIVRVTHARHILLSSLMGAVLLLAADILARWLLAPQELPVGVLTAALGGSYLLWLMHRRSTQGAGP

Sequences:

>Translated_307_residues
MGSTGWDSLLHLGDDPVAWQILWSIRLPRTLGAWLAGALLGLAGAVAQGLFRNPLADPYLLGSASGAALGAAVALALLGV
SPVAPQWLARIGITGMAFVGAAGAVLLTLLLARGVQHPLRLLLAGVIVGVVLGALRELLQLASPDILQAMQAFTLGSTAF
VGAPACVLMALAWVSCAALAWMLARALDGLTLGEATAASLGLPLLPMRAGLVAALALATGTAVAQTGLIAFVGLAAPHLL
RSIVRVTHARHILLSSLMGAVLLLAADILARWLLAPQELPVGVLTAALGGSYLLWLMHRRSTQGAGP
>Mature_306_residues
GSTGWDSLLHLGDDPVAWQILWSIRLPRTLGAWLAGALLGLAGAVAQGLFRNPLADPYLLGSASGAALGAAVALALLGVS
PVAPQWLARIGITGMAFVGAAGAVLLTLLLARGVQHPLRLLLAGVIVGVVLGALRELLQLASPDILQAMQAFTLGSTAFV
GAPACVLMALAWVSCAALAWMLARALDGLTLGEATAASLGLPLLPMRAGLVAALALATGTAVAQTGLIAFVGLAAPHLLR
SIVRVTHARHILLSSLMGAVLLLAADILARWLLAPQELPVGVLTAALGGSYLLWLMHRRSTQGAGP

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=288, Percent_Identity=39.2361111111111, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790740, Length=310, Percent_Identity=37.0967741935484, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786805, Length=290, Percent_Identity=37.5862068965517, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786347, Length=278, Percent_Identity=34.1726618705036, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790741, Length=280, Percent_Identity=32.8571428571429, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786804, Length=303, Percent_Identity=35.6435643564356, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 31242; Mature: 31111

Theoretical pI: Translated: 10.84; Mature: 10.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTGWDSLLHLGDDPVAWQILWSIRLPRTLGAWLAGALLGLAGAVAQGLFRNPLADPYL
CCCCHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LGSASGAALGAAVALALLGVSPVAPQWLARIGITGMAFVGAAGAVLLTLLLARGVQHPLR
ECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLAGVIVGVVLGALRELLQLASPDILQAMQAFTLGSTAFVGAPACVLMALAWVSCAALA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHH
WMLARALDGLTLGEATAASLGLPLLPMRAGLVAALALATGTAVAQTGLIAFVGLAAPHLL
HHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSIVRVTHARHILLSSLMGAVLLLAADILARWLLAPQELPVGVLTAALGGSYLLWLMHRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
STQGAGP
CCCCCCC
>Mature Secondary Structure 
GSTGWDSLLHLGDDPVAWQILWSIRLPRTLGAWLAGALLGLAGAVAQGLFRNPLADPYL
CCCHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LGSASGAALGAAVALALLGVSPVAPQWLARIGITGMAFVGAAGAVLLTLLLARGVQHPLR
ECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLAGVIVGVVLGALRELLQLASPDILQAMQAFTLGSTAFVGAPACVLMALAWVSCAALA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHH
WMLARALDGLTLGEATAASLGLPLLPMRAGLVAALALATGTAVAQTGLIAFVGLAAPHLL
HHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSIVRVTHARHILLSSLMGAVLLLAADILARWLLAPQELPVGVLTAALGGSYLLWLMHRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
STQGAGP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]