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The map label for this gene is dapA [H]

Identifier: 121611594

GI number: 121611594

Start: 5174321

End: 5175217

Strand: Direct

Name: dapA [H]

Synonym: Veis_4686

Alternate gene names: 121611594

Gene position: 5174321-5175217 (Clockwise)

Preceding gene: 121611593

Following gene: 121611595

Centisome position: 92.95

GC content: 67.78

Gene sequence:

>897_bases
ATGAACGTGACCCACAAGTACGCCGGCATCCTCACCGCGGTCCCCACGCCGCTGACTTCGGACCTGCAGGTTGACACCCG
CCCGTTGAGCGCCCACGTGCGCCGCATGGTCGAGGCGGGAAGCCGCGGCATCGTGCCGCTGGGCGGGACCGGCGAGTACA
CCTCGCTGTCGTTCGACCAGCGCCTGTCGGTGGTCGAGGCCTCGCTCGAAGCCGCCAGCGGCGCGACCGCCGTCATCCCC
GGCATCCTGTCGCCGGGCATCGGCGACGCGATCGACAACGCCAAGGCCTTCGTCCGGGCGGGCGCGAAGGCGTTGATGGT
CGTCACGCCCTACTACTTCAGGCCGACGCAGGACGGCATCGTCGAGTACTTCGAGCGCTTCTCGAACGAGGTTGACGCCG
ACATCATCCTCTACGAGATTCCCTACCGCACCGGCGTGTCGCTGAACTTCCAGACCGTGGACCGGCTGGCAGGCCTGACG
CGCGTGGTCGGCATCAAGGCCTGCAATCCCGATCTCGCGCAGCAGATGCGCGTGGCCGAACTCGCGGCTTCCAAGATCGC
GATCCTCACAGGCGAGGAAGACGTCATGCCGTTGCACGTCGCGATGGGCGCGGTCGGCGCGGTCATCACCAGCTCCAACC
TGCTGCCTCGCCAATGGGACCGCGTGCTCGAGCTCGGCCTCGCCGGCAAGCTGCAGGAGTCGATCGCCCTGCATGCCACG
CTGCGTCCGCTCATCGACGCGGTCTTCGCCGAACCCAATCCCGCGCCCATGAAGGCCGCGATGGACTTCCTCGGCTGGGG
CATGGGCTGCGACGTCCTGCCACCGATGAAGCAGGCCAGCGCGAAGATCAAGGAGCGCATCGCCCAGGTGCTCCCGCCGC
TGCGCGATCGCGAATAA

Upstream 100 bases:

>100_bases
AAAGAGCGACGTCGTTCGCCACTTATGTTCGGCGCATCGAGACGGAATCGCCTGCGCTTGGCCGGAACTTCCACCACCGA
CCTCAGCCCATCGACCACCC

Downstream 100 bases:

>100_bases
CCCGTTTCCGTCAACCCTCTCAAGGTGGTCATGATGTCTTCTCCTATTCCTACGAATCACGGTCGTCGCAAGTTCCTGCA
GACCACGGGCGCAGCGGCCG

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNVTHKYAGILTAVPTPLTSDLQVDTRPLSAHVRRMVEAGSRGIVPLGGTGEYTSLSFDQRLSVVEASLEAASGATAVIP
GILSPGIGDAIDNAKAFVRAGAKALMVVTPYYFRPTQDGIVEYFERFSNEVDADIILYEIPYRTGVSLNFQTVDRLAGLT
RVVGIKACNPDLAQQMRVAELAASKIAILTGEEDVMPLHVAMGAVGAVITSSNLLPRQWDRVLELGLAGKLQESIALHAT
LRPLIDAVFAEPNPAPMKAAMDFLGWGMGCDVLPPMKQASAKIKERIAQVLPPLRDRE

Sequences:

>Translated_298_residues
MNVTHKYAGILTAVPTPLTSDLQVDTRPLSAHVRRMVEAGSRGIVPLGGTGEYTSLSFDQRLSVVEASLEAASGATAVIP
GILSPGIGDAIDNAKAFVRAGAKALMVVTPYYFRPTQDGIVEYFERFSNEVDADIILYEIPYRTGVSLNFQTVDRLAGLT
RVVGIKACNPDLAQQMRVAELAASKIAILTGEEDVMPLHVAMGAVGAVITSSNLLPRQWDRVLELGLAGKLQESIALHAT
LRPLIDAVFAEPNPAPMKAAMDFLGWGMGCDVLPPMKQASAKIKERIAQVLPPLRDRE
>Mature_298_residues
MNVTHKYAGILTAVPTPLTSDLQVDTRPLSAHVRRMVEAGSRGIVPLGGTGEYTSLSFDQRLSVVEASLEAASGATAVIP
GILSPGIGDAIDNAKAFVRAGAKALMVVTPYYFRPTQDGIVEYFERFSNEVDADIILYEIPYRTGVSLNFQTVDRLAGLT
RVVGIKACNPDLAQQMRVAELAASKIAILTGEEDVMPLHVAMGAVGAVITSSNLLPRQWDRVLELGLAGKLQESIALHAT
LRPLIDAVFAEPNPAPMKAAMDFLGWGMGCDVLPPMKQASAKIKERIAQVLPPLRDRE

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=25.2669039145907, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788823, Length=259, Percent_Identity=30.8880308880309, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI87082415, Length=292, Percent_Identity=24.6575342465753, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786463, Length=278, Percent_Identity=24.8201438848921, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789620, Length=239, Percent_Identity=22.5941422594142, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31974; Mature: 31974

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTHKYAGILTAVPTPLTSDLQVDTRPLSAHVRRMVEAGSRGIVPLGGTGEYTSLSFDQ
CCCCHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHH
RLSVVEASLEAASGATAVIPGILSPGIGDAIDNAKAFVRAGAKALMVVTPYYFRPTQDGI
HHHHHHHHHHHCCCCCEECCHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCEECCCHHHH
VEYFERFSNEVDADIILYEIPYRTGVSLNFQTVDRLAGLTRVVGIKACNPDLAQQMRVAE
HHHHHHHCCCCCCEEEEEEECCCCCCEECHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
LAASKIAILTGEEDVMPLHVAMGAVGAVITSSNLLPRQWDRVLELGLAGKLQESIALHAT
HHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
LRPLIDAVFAEPNPAPMKAAMDFLGWGMGCDVLPPMKQASAKIKERIAQVLPPLRDRE
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNVTHKYAGILTAVPTPLTSDLQVDTRPLSAHVRRMVEAGSRGIVPLGGTGEYTSLSFDQ
CCCCHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHH
RLSVVEASLEAASGATAVIPGILSPGIGDAIDNAKAFVRAGAKALMVVTPYYFRPTQDGI
HHHHHHHHHHHCCCCCEECCHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCEECCCHHHH
VEYFERFSNEVDADIILYEIPYRTGVSLNFQTVDRLAGLTRVVGIKACNPDLAQQMRVAE
HHHHHHHCCCCCCEEEEEEECCCCCCEECHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
LAASKIAILTGEEDVMPLHVAMGAVGAVITSSNLLPRQWDRVLELGLAGKLQESIALHAT
HHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
LRPLIDAVFAEPNPAPMKAAMDFLGWGMGCDVLPPMKQASAKIKERIAQVLPPLRDRE
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA