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The map label for this gene is iclR [H]

Identifier: 121610918

GI number: 121610918

Start: 4391476

End: 4392360

Strand: Direct

Name: iclR [H]

Synonym: Veis_4000

Alternate gene names: 121610918

Gene position: 4391476-4392360 (Clockwise)

Preceding gene: 121610915

Following gene: 121610930

Centisome position: 78.89

GC content: 69.38

Gene sequence:

>885_bases
ATGATCGGCCCGATGAAGACCGTCATCACGCCGCCAGCGCCGCAAGCTGCGGACGGCACGCCCAAGGCCCCCGACCCGGC
GGGCGACACGCCCAAAGCGCCGGAACTGGTGGGCGACACGCCCACCATGCGCCTGATCGGGCTGCTCGAAGTCATTGCCG
GCAAAGACCGGCGCTATTCGCTGCAGGGCCTGGTGCAAGAGACCGGCCTGCCCAAACCCACGCTGCACCGCATGTTGCAG
CAGCTCGAAAGCACGGGACTGCTGCAACGCGAGGGCAACGGGCGCCACTACGGCATCGGCACGCGGCTGCGGCGCCTGGC
CGAGAACCTGCTGCTCAACGACAGCTTGCACGGCGCGCGCCACATGGTGCTGCGCCAACTGGTCCAGGAGATCGGCGAAA
GCTGCAACCTGACGGCCCTGTCGGGCAGCGAGGTGGTGTACCTCGACCGCGTGGAAACCGCTGCGCCGCTGCGCTTTTAC
CTGCACCCGGGTTCGCGCGTGCCGGTGCACTGCTCGGCCAGCGGCAAGATCTTTCTCGCGCAAATGAGCCTGGCGCAGCG
GCGCCGCCTGCTGTCGAACGCGCCGCTGGAGCCGTACACGCCCAAGACACTGACCGACCCCGAAGCGCTGGAGAAGGAAA
TGCGGCGCGTGCGCAAGAACGGCTTTGCCATCGACAACGAAGAATTCCTGCCGGGCCTGCTGTGCATCGCCGCGCTGGTG
CCCTCGGGCGACGGGGGCCCGTCGAACCTGTGCATCGCGGTGCAGGCGCCGGTCATGCGGCTCGACGCCACCAAGGCCAA
GGGACTGCTGCCCGCGCTGCAACGCGCCACGCTGGCGCTCAGCCGCATCGCCGCCGACAGCGCAGGCCCGGCCCCGGATG
CCTGA

Upstream 100 bases:

>100_bases
AACCATTTATTCCGAATTAATTTATACGAAATATAGGCTGGCCAGGCCGTGGCGTCAAACGATCGATGAAAACCGGAACG
CCCGGCTTGGTCAAAAGGCT

Downstream 100 bases:

>100_bases
CCCCCGGGTTTTCCGGCAGACCCCCTAATCCCCCTACCCCCTGTGACCGATACCGCAGACCGCAGCGGATGCCGGGCGTG
CGCGCCCTGCCCGGTATCGA

Product: regulatory protein IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MIGPMKTVITPPAPQAADGTPKAPDPAGDTPKAPELVGDTPTMRLIGLLEVIAGKDRRYSLQGLVQETGLPKPTLHRMLQ
QLESTGLLQREGNGRHYGIGTRLRRLAENLLLNDSLHGARHMVLRQLVQEIGESCNLTALSGSEVVYLDRVETAAPLRFY
LHPGSRVPVHCSASGKIFLAQMSLAQRRRLLSNAPLEPYTPKTLTDPEALEKEMRRVRKNGFAIDNEEFLPGLLCIAALV
PSGDGGPSNLCIAVQAPVMRLDATKAKGLLPALQRATLALSRIAADSAGPAPDA

Sequences:

>Translated_294_residues
MIGPMKTVITPPAPQAADGTPKAPDPAGDTPKAPELVGDTPTMRLIGLLEVIAGKDRRYSLQGLVQETGLPKPTLHRMLQ
QLESTGLLQREGNGRHYGIGTRLRRLAENLLLNDSLHGARHMVLRQLVQEIGESCNLTALSGSEVVYLDRVETAAPLRFY
LHPGSRVPVHCSASGKIFLAQMSLAQRRRLLSNAPLEPYTPKTLTDPEALEKEMRRVRKNGFAIDNEEFLPGLLCIAALV
PSGDGGPSNLCIAVQAPVMRLDATKAKGLLPALQRATLALSRIAADSAGPAPDA
>Mature_294_residues
MIGPMKTVITPPAPQAADGTPKAPDPAGDTPKAPELVGDTPTMRLIGLLEVIAGKDRRYSLQGLVQETGLPKPTLHRMLQ
QLESTGLLQREGNGRHYGIGTRLRRLAENLLLNDSLHGARHMVLRQLVQEIGESCNLTALSGSEVVYLDRVETAAPLRFY
LHPGSRVPVHCSASGKIFLAQMSLAQRRRLLSNAPLEPYTPKTLTDPEALEKEMRRVRKNGFAIDNEEFLPGLLCIAALV
PSGDGGPSNLCIAVQAPVMRLDATKAKGLLPALQRATLALSRIAADSAGPAPDA

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=220, Percent_Identity=33.1818181818182, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788131, Length=255, Percent_Identity=27.843137254902, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786468, Length=215, Percent_Identity=29.3023255813954, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786715, Length=218, Percent_Identity=25.6880733944954, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788581, Length=175, Percent_Identity=27.4285714285714, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789999, Length=250, Percent_Identity=28, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790752, Length=181, Percent_Identity=26.5193370165746, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 31571; Mature: 31571

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGPMKTVITPPAPQAADGTPKAPDPAGDTPKAPELVGDTPTMRLIGLLEVIAGKDRRYS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHH
LQGLVQETGLPKPTLHRMLQQLESTGLLQREGNGRHYGIGTRLRRLAENLLLNDSLHGAR
HHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCEECHHHHHHHHHHHHHHCCCCHHHH
HMVLRQLVQEIGESCNLTALSGSEVVYLDRVETAAPLRFYLHPGSRVPVHCSASGKIFLA
HHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCEEEEECCCCCCCEEECCCCCEEEH
QMSLAQRRRLLSNAPLEPYTPKTLTDPEALEKEMRRVRKNGFAIDNEEFLPGLLCIAALV
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
PSGDGGPSNLCIAVQAPVMRLDATKAKGLLPALQRATLALSRIAADSAGPAPDA
CCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIGPMKTVITPPAPQAADGTPKAPDPAGDTPKAPELVGDTPTMRLIGLLEVIAGKDRRYS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHH
LQGLVQETGLPKPTLHRMLQQLESTGLLQREGNGRHYGIGTRLRRLAENLLLNDSLHGAR
HHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCEECHHHHHHHHHHHHHHCCCCHHHH
HMVLRQLVQEIGESCNLTALSGSEVVYLDRVETAAPLRFYLHPGSRVPVHCSASGKIFLA
HHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCEEEEECCCCCCCEEECCCCCEEEH
QMSLAQRRRLLSNAPLEPYTPKTLTDPEALEKEMRRVRKNGFAIDNEEFLPGLLCIAALV
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
PSGDGGPSNLCIAVQAPVMRLDATKAKGLLPALQRATLALSRIAADSAGPAPDA
CCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]