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The map label for this gene is gbsB [H]

Identifier: 121610794

GI number: 121610794

Start: 4270886

End: 4272085

Strand: Direct

Name: gbsB [H]

Synonym: Veis_3875

Alternate gene names: 121610794

Gene position: 4270886-4272085 (Clockwise)

Preceding gene: 121610793

Following gene: 121610795

Centisome position: 76.72

GC content: 69.92

Gene sequence:

>1200_bases
ATGTATCCACCATCGACACATCTGCTGTTCGGCACCGAGCCCGACCAGTACACCTTCGTCTGGCCCGGCCAGACGGTATT
CGGGGCCGGCAGCGCCGAGCGCCTGTCCGCATGGATGCAGCACAGCGGTTCGCGAAAGCCGCTGGTGGTCAGCGATGCCG
GTCTGGTAGCCGCCGGCCTGGTCGAACCGCACCTCGCGCGCCTGCGCGACGCCGGCCTGGTACCGTGCCTGTTCGACGGC
GTGGAGGCCAATCCCACGCTGGACAACGTCGCCCAGGCCCTTGACCTCTGGCACTCGCAGGCCTGCGACGGCGTGGTCGC
GCTCGGCGGCGGCAGCGTGATCGACGTCTGCAAGGTACTGCTGGCCCGGCTGTGCAGCGATGCGCCCGTGGAGCAGGTGC
TGCGCGAGGGCGACGCGCTGCTGTGCCGGCCGATCCCGCCGTTCGCGGCCATTCCGACCACCGCGGGCACCGGCAGCGAA
AGCACCACCGCCGCATTGGTCAAGGACGCCCAGGGGCGCAAACATGTGCTGCGCAGCCGCGCATGCCGCCCGCAATGGGT
GGCGCTGGACCCGCTGCTGACACTGAGCGTCCCGCCCGCTGTCACGGCCTGCACCGGCTTCGACACGGTGATGCACGCAC
TGGGCGCGGCCACCAACCGCGCCACCAATCCCGTCGGCGAAGCCCTGGCCCTGCAAGCCATGGTGCTTTCGTTCCATGCA
CTGCCGCTAGTGATCGCTCAGCCCGACGCGCTGCAGGCACGCAGCGACATGCTGCTGGCCAGCTACCTGGCCGGCGTGGC
AATGAGTCTGCGCGGCACCGACGGCATTCACGGGCTTTGCACGCCGCTGGAATCGCTGGTCGACGTGCCGCACGCGCATG
TGCTGGCGGTCGTGTGCGTGCCCCTGATGCGCTTCACGCTGCCGGCCGCCACGTCTCCCTACGCCAGAGTGGCGCGCGCC
TGCGGCCTGTCCGCAAAGCCCGCGGACGATGCAGCCTGCGCCGCAGAACTGGTCGAAGCCATCGACCACCTGCGCAGAGC
GGCTCGGCTGCCATGCACATTGGCCGAACTCGGCGTCAAGGCGGACCGGCTCGAAGCCGTGATCGGCATCGCACTCGGCA
GCCCTTCCGTGGCGCTGAACGCCCGCAAGCCGACACGGGACGACCTGGTCTCGCTCTACCGGGCTATGCAGCCCGCCTGA

Upstream 100 bases:

>100_bases
TCCATGCGGCGCTGCCGCGTGAAGGTATGGGCAAGGTGTTCAAGAACCAGTTGCGCGCCCCGCACTGGGAACGCGCCGGC
CGCCGCATCTGAGAAACGCC

Downstream 100 bases:

>100_bases
ATTCCACCGTGTTCTTCACCCCTTATCCAGCACCATGCAAACATCCTCGCATCTGCGCACCGGCACCTATCCCTTACTGA
TCGACGGCCAGGAGCGCTCC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYPPSTHLLFGTEPDQYTFVWPGQTVFGAGSAERLSAWMQHSGSRKPLVVSDAGLVAAGLVEPHLARLRDAGLVPCLFDG
VEANPTLDNVAQALDLWHSQACDGVVALGGGSVIDVCKVLLARLCSDAPVEQVLREGDALLCRPIPPFAAIPTTAGTGSE
STTAALVKDAQGRKHVLRSRACRPQWVALDPLLTLSVPPAVTACTGFDTVMHALGAATNRATNPVGEALALQAMVLSFHA
LPLVIAQPDALQARSDMLLASYLAGVAMSLRGTDGIHGLCTPLESLVDVPHAHVLAVVCVPLMRFTLPAATSPYARVARA
CGLSAKPADDAACAAELVEAIDHLRRAARLPCTLAELGVKADRLEAVIGIALGSPSVALNARKPTRDDLVSLYRAMQPA

Sequences:

>Translated_399_residues
MYPPSTHLLFGTEPDQYTFVWPGQTVFGAGSAERLSAWMQHSGSRKPLVVSDAGLVAAGLVEPHLARLRDAGLVPCLFDG
VEANPTLDNVAQALDLWHSQACDGVVALGGGSVIDVCKVLLARLCSDAPVEQVLREGDALLCRPIPPFAAIPTTAGTGSE
STTAALVKDAQGRKHVLRSRACRPQWVALDPLLTLSVPPAVTACTGFDTVMHALGAATNRATNPVGEALALQAMVLSFHA
LPLVIAQPDALQARSDMLLASYLAGVAMSLRGTDGIHGLCTPLESLVDVPHAHVLAVVCVPLMRFTLPAATSPYARVARA
CGLSAKPADDAACAAELVEAIDHLRRAARLPCTLAELGVKADRLEAVIGIALGSPSVALNARKPTRDDLVSLYRAMQPA
>Mature_399_residues
MYPPSTHLLFGTEPDQYTFVWPGQTVFGAGSAERLSAWMQHSGSRKPLVVSDAGLVAAGLVEPHLARLRDAGLVPCLFDG
VEANPTLDNVAQALDLWHSQACDGVVALGGGSVIDVCKVLLARLCSDAPVEQVLREGDALLCRPIPPFAAIPTTAGTGSE
STTAALVKDAQGRKHVLRSRACRPQWVALDPLLTLSVPPAVTACTGFDTVMHALGAATNRATNPVGEALALQAMVLSFHA
LPLVIAQPDALQARSDMLLASYLAGVAMSLRGTDGIHGLCTPLESLVDVPHAHVLAVVCVPLMRFTLPAATSPYARVARA
CGLSAKPADDAACAAELVEAIDHLRRAARLPCTLAELGVKADRLEAVIGIALGSPSVALNARKPTRDDLVSLYRAMQPA

Specific function: Essential for the utilization of choline as a precursor [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=324, Percent_Identity=28.7037037037037, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1789163, Length=371, Percent_Identity=30.4582210242588, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=29.287598944591, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI87082107, Length=381, Percent_Identity=30.4461942257218, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1787493, Length=355, Percent_Identity=29.5774647887324, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789386, Length=369, Percent_Identity=22.4932249322493, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537053, Length=409, Percent_Identity=26.4058679706601, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321181, Length=379, Percent_Identity=28.4960422163588, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24657991, Length=420, Percent_Identity=27.1428571428571, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41702; Mature: 41702

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPPSTHLLFGTEPDQYTFVWPGQTVFGAGSAERLSAWMQHSGSRKPLVVSDAGLVAAGL
CCCCCCCEEECCCCCCEEEEECCCEEECCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHH
VEPHLARLRDAGLVPCLFDGVEANPTLDNVAQALDLWHSQACDGVVALGGGSVIDVCKVL
HHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
LARLCSDAPVEQVLREGDALLCRPIPPFAAIPTTAGTGSESTTAALVKDAQGRKHVLRSR
HHHHHCCCCHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHC
ACRPQWVALDPLLTLSVPPAVTACTGFDTVMHALGAATNRATNPVGEALALQAMVLSFHA
CCCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LPLVIAQPDALQARSDMLLASYLAGVAMSLRGTDGIHGLCTPLESLVDVPHAHVLAVVCV
HHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
PLMRFTLPAATSPYARVARACGLSAKPADDAACAAELVEAIDHLRRAARLPCTLAELGVK
HHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
ADRLEAVIGIALGSPSVALNARKPTRDDLVSLYRAMQPA
HHHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MYPPSTHLLFGTEPDQYTFVWPGQTVFGAGSAERLSAWMQHSGSRKPLVVSDAGLVAAGL
CCCCCCCEEECCCCCCEEEEECCCEEECCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHH
VEPHLARLRDAGLVPCLFDGVEANPTLDNVAQALDLWHSQACDGVVALGGGSVIDVCKVL
HHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
LARLCSDAPVEQVLREGDALLCRPIPPFAAIPTTAGTGSESTTAALVKDAQGRKHVLRSR
HHHHHCCCCHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHC
ACRPQWVALDPLLTLSVPPAVTACTGFDTVMHALGAATNRATNPVGEALALQAMVLSFHA
CCCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LPLVIAQPDALQARSDMLLASYLAGVAMSLRGTDGIHGLCTPLESLVDVPHAHVLAVVCV
HHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
PLMRFTLPAATSPYARVARACGLSAKPADDAACAAELVEAIDHLRRAARLPCTLAELGVK
HHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
ADRLEAVIGIALGSPSVALNARKPTRDDLVSLYRAMQPA
HHHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8752328; 9384377 [H]