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The map label for this gene is echA8 [H]

Identifier: 121610761

GI number: 121610761

Start: 4239285

End: 4240097

Strand: Direct

Name: echA8 [H]

Synonym: Veis_3841

Alternate gene names: 121610761

Gene position: 4239285-4240097 (Clockwise)

Preceding gene: 121610760

Following gene: 121610762

Centisome position: 76.15

GC content: 63.1

Gene sequence:

>813_bases
ATGGGCTATCAACACATTCTCTACGCGGTGGATCATCACATCGCCACCATCACGCTCAACCGCCCGGCCCGCCTGAACGC
CTGGACGGCCACCATGGAGCGGGAGGTACGCCAGGCGATGGAGCAGGCGGCGGACGATGACGGCGTGCGCGCCATCGTGC
TCACAGGCGCTGGTCGCGGCTTTTGCGCAGGCGCCGACATGGACGAACTCAAAGACCTCGATCCCAACGACATCAAAAGC
GACGCCTGGAGCCGGCCTTTTGACATGAATCGCCGTGCCGACTACCAGACCCGCTATGGCTTCTACCCTGCGCTGCCCAA
GCCGGTGATCGGCATGCTCAACGGTGCCACCGCCGGGATTGGGCTGGTGCATGCGCTGTACTGCGACATCCGCTTCGCCG
CAGACACAGCGGTTTTCACCACGTCGTTTTCCCGCCGCGGCCTGATTGCCGAGCATGGCCTGAGCTGGATGCTGCCATTG
ATCGTCGGCCATGCGAATGCGCTCGATCTGCTGTTGTCGGCGCGCAAGGTGCAGGCTTGCGAGGCGCTGTCCATGGGGCT
GGTGAACCAAGTGTTTCCAGCCGACAAGCTCCTGGAGCAGACCTCTGCCTATGTGCGTGACCTGGTGGACAACGTCTCAC
CGCGTTCCATGCGGGTGATCAAGCGCCAGCAGTACGACGCCCCCTTCCAGACGCTGGCGGAAAACACGCTGGCCGCGAAT
GCCGAGATGTCGCAAAGCGTCCTGAGCGCAGACTTCAGGGAGGGAGTGGCGCATTTTCTGGAAAAACGCCCCGCCCGCTT
CACCGGCCATTGA

Upstream 100 bases:

>100_bases
CCCTGCGGTGCAAGCCTATCTGCAACGTCCCAAAGGCCGCTGGCCTGGCCCTGCACAGTGATGTGCAGACCCTGCGGCTT
TTTCTGACTGGAGTGTCACC

Downstream 100 bases:

>100_bases
TCCTGTCCGGGTGCGATCGTGCCCTGCGACCAGCCTCTGGCCATGGCCGCATCGGCGGCGCAATGGGCGATGCGGCCCCA
TGGTCCGCAACGTCGCCATG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MGYQHILYAVDHHIATITLNRPARLNAWTATMEREVRQAMEQAADDDGVRAIVLTGAGRGFCAGADMDELKDLDPNDIKS
DAWSRPFDMNRRADYQTRYGFYPALPKPVIGMLNGATAGIGLVHALYCDIRFAADTAVFTTSFSRRGLIAEHGLSWMLPL
IVGHANALDLLLSARKVQACEALSMGLVNQVFPADKLLEQTSAYVRDLVDNVSPRSMRVIKRQQYDAPFQTLAENTLAAN
AEMSQSVLSADFREGVAHFLEKRPARFTGH

Sequences:

>Translated_270_residues
MGYQHILYAVDHHIATITLNRPARLNAWTATMEREVRQAMEQAADDDGVRAIVLTGAGRGFCAGADMDELKDLDPNDIKS
DAWSRPFDMNRRADYQTRYGFYPALPKPVIGMLNGATAGIGLVHALYCDIRFAADTAVFTTSFSRRGLIAEHGLSWMLPL
IVGHANALDLLLSARKVQACEALSMGLVNQVFPADKLLEQTSAYVRDLVDNVSPRSMRVIKRQQYDAPFQTLAENTLAAN
AEMSQSVLSADFREGVAHFLEKRPARFTGH
>Mature_269_residues
GYQHILYAVDHHIATITLNRPARLNAWTATMEREVRQAMEQAADDDGVRAIVLTGAGRGFCAGADMDELKDLDPNDIKSD
AWSRPFDMNRRADYQTRYGFYPALPKPVIGMLNGATAGIGLVHALYCDIRFAADTAVFTTSFSRRGLIAEHGLSWMLPLI
VGHANALDLLLSARKVQACEALSMGLVNQVFPADKLLEQTSAYVRDLVDNVSPRSMRVIKRQQYDAPFQTLAENTLAANA
EMSQSVLSADFREGVAHFLEKRPARFTGH

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=258, Percent_Identity=29.0697674418605, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI45643119, Length=266, Percent_Identity=27.4436090225564, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI260275230, Length=266, Percent_Identity=27.4436090225564, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI260274832, Length=266, Percent_Identity=27.4436090225564, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI70995211, Length=214, Percent_Identity=32.2429906542056, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4502327, Length=266, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI221307494, Length=208, Percent_Identity=27.4038461538462, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221136756, Length=208, Percent_Identity=27.4038461538462, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221136753, Length=208, Percent_Identity=27.4038461538462, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI116235487, Length=191, Percent_Identity=30.8900523560209, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI20127408, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25453481, Length=208, Percent_Identity=26.4423076923077, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538573, Length=208, Percent_Identity=26.4423076923077, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4757968, Length=210, Percent_Identity=25.2380952380952, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI49355787, Length=210, Percent_Identity=25.2380952380952, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4757966, Length=208, Percent_Identity=26.4423076923077, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538581, Length=208, Percent_Identity=26.4423076923077, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI68989263, Length=188, Percent_Identity=30.3191489361702, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=220, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI157694516, Length=220, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=35.2059925093633, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1788597, Length=270, Percent_Identity=32.2222222222222, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787659, Length=281, Percent_Identity=30.6049822064057, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=29.8429319371728, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=27.6515151515151, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082183, Length=278, Percent_Identity=25.1798561151079, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=31.3953488372093, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=28.90625, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=218, Percent_Identity=32.1100917431193, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=264, Percent_Identity=28.030303030303, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17534483, Length=259, Percent_Identity=28.957528957529, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535521, Length=258, Percent_Identity=27.906976744186, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=197, Percent_Identity=30.4568527918782, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=27.3684210526316, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129971, Length=260, Percent_Identity=30.3846153846154, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653477, Length=260, Percent_Identity=30.3846153846154, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24654903, Length=262, Percent_Identity=25.1908396946565, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653139, Length=268, Percent_Identity=32.089552238806, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920382, Length=249, Percent_Identity=29.3172690763052, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357171, Length=193, Percent_Identity=31.6062176165803, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650670, Length=198, Percent_Identity=31.8181818181818, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922422, Length=264, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29870; Mature: 29739

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYQHILYAVDHHIATITLNRPARLNAWTATMEREVRQAMEQAADDDGVRAIVLTGAGRG
CCHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
FCAGADMDELKDLDPNDIKSDAWSRPFDMNRRADYQTRYGFYPALPKPVIGMLNGATAGI
EECCCCHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHCCCHHHH
GLVHALYCDIRFAADTAVFTTSFSRRGLIAEHGLSWMLPLIVGHANALDLLLSARKVQAC
HHHHHHHHHHHHHCCHHHEECCCCCCCCHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHH
EALSMGLVNQVFPADKLLEQTSAYVRDLVDNVSPRSMRVIKRQQYDAPFQTLAENTLAAN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
AEMSQSVLSADFREGVAHFLEKRPARFTGH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GYQHILYAVDHHIATITLNRPARLNAWTATMEREVRQAMEQAADDDGVRAIVLTGAGRG
CHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
FCAGADMDELKDLDPNDIKSDAWSRPFDMNRRADYQTRYGFYPALPKPVIGMLNGATAGI
EECCCCHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHCCCHHHH
GLVHALYCDIRFAADTAVFTTSFSRRGLIAEHGLSWMLPLIVGHANALDLLLSARKVQAC
HHHHHHHHHHHHHCCHHHEECCCCCCCCHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHH
EALSMGLVNQVFPADKLLEQTSAYVRDLVDNVSPRSMRVIKRQQYDAPFQTLAENTLAAN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
AEMSQSVLSADFREGVAHFLEKRPARFTGH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]