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The map label for this gene is braC [H]

Identifier: 121610756

GI number: 121610756

Start: 4233994

End: 4235226

Strand: Direct

Name: braC [H]

Synonym: Veis_3836

Alternate gene names: 121610756

Gene position: 4233994-4235226 (Clockwise)

Preceding gene: 121610755

Following gene: 121610757

Centisome position: 76.06

GC content: 61.64

Gene sequence:

>1233_bases
ATGGCGCAACGACACGGCAGGCATGGCCTGGTGGCAGCATGCATGGGACTGGCAGGGATGACGGTGGCGCTGGTCGCGCA
CGCTGCGGACAAGACCTTGACCGTGGGGGTCAGTGATGCCCTGTCGGGTGGCGGGGCGGTGTATGGCGTACCCGAACTGC
GCGCCATCGAACTGGCCGTCGAAGAGGTCAACGCCGCAGGGGGGATTCCTGTCGGTGGCGATGCCTACCGGCTCAAGACC
ATCTCCTATGACGACAAGGCCGATCCCACCGAGGCGACCAATGTGGCGCGCAAACTGCTCGACCGCGACGGCGTCAAAGT
CTTGCTGGGCTACTGCTGCTCGGCCTCGGGAGGCGCAGTGGCGTCTTTCATGGGGCGCGAGGATGCGTTGATGCTGGTGG
GCACGGCAGGCGCGCGCGATATCACCGCTGCGGGCAACCCGAATGTGTTTCGCACCCGTCCGCCGGGTGATTACACCGGC
GCTGCGGCGGGGCGCTATCTCTACGACAAGGGGGTGCGCACGCTGGGCATCCTGGGGGTGCGTGATGTGGCCTTGTTCAC
CCAGTACCGCGAGGCATTGATCAAGCGTTTCGAGCAGGCTGGTGGCAAGGTGGTGGCGCTGGAGACCTTTGGCGGACATG
ACCGTGACATGACCCCGCAACTGACCAAGCTCAAGCGCCTGGATCCCGATGCGGTCTTTATTTCGGGCTATGTCGAGCAG
GCCGCGTTTGCCTACCGCCAATTCAAAGAAATTGGCATGAAAATGCCGCGCTACGGCTTTAGCGGCGGCAGCGAAAGGCA
GTTTCTGAAAGTGGCCAGCAGCGAGCAGATGGAAGGGGTGACCGACCTGCTGTCGGTGGAGTTTTCGGTGCAGGCGCTGG
GCAGCGAAAATGCCAAGCGTTTTGCCGATGCCTACAAGAAAAAGTACGGCGAGGAGCCTACCCCCAACACCGCCTATGCC
TACGATCAGGTCTACGTGCTGCGTGATGCGCTCAAGAGTGCGCAAAGCACGAGCGATGTCAAGAAGCTGATCGCAGCGTT
GCGCGGCCTGCCCGTGCCCAAGGAAGTCTTGCTCAAATACCAACCGATCGACGGAAAGATGTTTGACGGGAACGGCCAAG
CCTATATCTCCAATGGCGCATTCCAGTGGAAGCAGGGTCAGTGGCAGTTCCTGGGCGAGTTGCCTTCGGATGCCAAGGCC
TATTCGGCTTACCTGCGTTCGTTGCGCAAATAG

Upstream 100 bases:

>100_bases
AGCCTGCGCGACAACCCCGAGATCAGCAATGCCTACCTGGGGCATTGAGGTCGACTTTTCGGTGATGGGCCTGTGGCGAA
TTTCAAAGGAGTGAGACAAC

Downstream 100 bases:

>100_bases
GCTGGATCCGGAGCCAGCCCCCACGATCCGACGCCCCCATGCTGCACAGGGTGTGCCGTGTTCATCGAACTGATACAACA
AATTCTCAACGGTCTGGTCG

Product: extracellular ligand-binding receptor

Products: ADP; phosphate; L-leucine [Cytoplasm] [C]

Alternate protein names: LIVAT-BP; Leu/Ile/Val/Thr/Ala-binding protein [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAQRHGRHGLVAACMGLAGMTVALVAHAADKTLTVGVSDALSGGGAVYGVPELRAIELAVEEVNAAGGIPVGGDAYRLKT
ISYDDKADPTEATNVARKLLDRDGVKVLLGYCCSASGGAVASFMGREDALMLVGTAGARDITAAGNPNVFRTRPPGDYTG
AAAGRYLYDKGVRTLGILGVRDVALFTQYREALIKRFEQAGGKVVALETFGGHDRDMTPQLTKLKRLDPDAVFISGYVEQ
AAFAYRQFKEIGMKMPRYGFSGGSERQFLKVASSEQMEGVTDLLSVEFSVQALGSENAKRFADAYKKKYGEEPTPNTAYA
YDQVYVLRDALKSAQSTSDVKKLIAALRGLPVPKEVLLKYQPIDGKMFDGNGQAYISNGAFQWKQGQWQFLGELPSDAKA
YSAYLRSLRK

Sequences:

>Translated_410_residues
MAQRHGRHGLVAACMGLAGMTVALVAHAADKTLTVGVSDALSGGGAVYGVPELRAIELAVEEVNAAGGIPVGGDAYRLKT
ISYDDKADPTEATNVARKLLDRDGVKVLLGYCCSASGGAVASFMGREDALMLVGTAGARDITAAGNPNVFRTRPPGDYTG
AAAGRYLYDKGVRTLGILGVRDVALFTQYREALIKRFEQAGGKVVALETFGGHDRDMTPQLTKLKRLDPDAVFISGYVEQ
AAFAYRQFKEIGMKMPRYGFSGGSERQFLKVASSEQMEGVTDLLSVEFSVQALGSENAKRFADAYKKKYGEEPTPNTAYA
YDQVYVLRDALKSAQSTSDVKKLIAALRGLPVPKEVLLKYQPIDGKMFDGNGQAYISNGAFQWKQGQWQFLGELPSDAKA
YSAYLRSLRK
>Mature_409_residues
AQRHGRHGLVAACMGLAGMTVALVAHAADKTLTVGVSDALSGGGAVYGVPELRAIELAVEEVNAAGGIPVGGDAYRLKTI
SYDDKADPTEATNVARKLLDRDGVKVLLGYCCSASGGAVASFMGREDALMLVGTAGARDITAAGNPNVFRTRPPGDYTGA
AAGRYLYDKGVRTLGILGVRDVALFTQYREALIKRFEQAGGKVVALETFGGHDRDMTPQLTKLKRLDPDAVFISGYVEQA
AFAYRQFKEIGMKMPRYGFSGGSERQFLKVASSEQMEGVTDLLSVEFSVQALGSENAKRFADAYKKKYGEEPTPNTAYAY
DQVYVLRDALKSAQSTSDVKKLIAALRGLPVPKEVLLKYQPIDGKMFDGNGQAYISNGAFQWKQGQWQFLGELPSDAKAY
SAYLRSLRK

Specific function: Component of the high-affinity leucine, isoleucine, valine transport system I (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG0683

COG function: function code E; ABC-type branched-chain amino acid transport systems, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leucine-binding protein family [H]

Homologues:

Organism=Escherichia coli, GI48994941, Length=275, Percent_Identity=29.8181818181818, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789867, Length=251, Percent_Identity=28.6852589641434, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001828
- InterPro:   IPR000709 [H]

Pfam domain/function: PF01094 ANF_receptor [H]

EC number: NA

Molecular weight: Translated: 44135; Mature: 44004

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRHGRHGLVAACMGLAGMTVALVAHAADKTLTVGVSDALSGGGAVYGVPELRAIELAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEECCCCHHHHHHHH
EEVNAAGGIPVGGDAYRLKTISYDDKADPTEATNVARKLLDRDGVKVLLGYCCSASGGAV
HHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHH
ASFMGREDALMLVGTAGARDITAAGNPNVFRTRPPGDYTGAAAGRYLYDKGVRTLGILGV
HHHCCCCCCEEEEECCCCCCEECCCCCCEEECCCCCCCCCCCCCCHHHHCCCHHEEHHHH
RDVALFTQYREALIKRFEQAGGKVVALETFGGHDRDMTPQLTKLKRLDPDAVFISGYVEQ
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEHHHHHH
AAFAYRQFKEIGMKMPRYGFSGGSERQFLKVASSEQMEGVTDLLSVEFSVQALGSENAKR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCHHHH
FADAYKKKYGEEPTPNTAYAYDQVYVLRDALKSAQSTSDVKKLIAALRGLPVPKEVLLKY
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHEEE
QPIDGKMFDGNGQAYISNGAFQWKQGQWQFLGELPSDAKAYSAYLRSLRK
CCCCCEEECCCCCEEEECCEEEECCCCHHEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQRHGRHGLVAACMGLAGMTVALVAHAADKTLTVGVSDALSGGGAVYGVPELRAIELAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEECCCCHHHHHHHH
EEVNAAGGIPVGGDAYRLKTISYDDKADPTEATNVARKLLDRDGVKVLLGYCCSASGGAV
HHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHH
ASFMGREDALMLVGTAGARDITAAGNPNVFRTRPPGDYTGAAAGRYLYDKGVRTLGILGV
HHHCCCCCCEEEEECCCCCCEECCCCCCEEECCCCCCCCCCCCCCHHHHCCCHHEEHHHH
RDVALFTQYREALIKRFEQAGGKVVALETFGGHDRDMTPQLTKLKRLDPDAVFISGYVEQ
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEHHHHHH
AAFAYRQFKEIGMKMPRYGFSGGSERQFLKVASSEQMEGVTDLLSVEFSVQALGSENAKR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCHHHH
FADAYKKKYGEEPTPNTAYAYDQVYVLRDALKSAQSTSDVKKLIAALRGLPVPKEVLLKY
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHEEE
QPIDGKMFDGNGQAYISNGAFQWKQGQWQFLGELPSDAKAYSAYLRSLRK
CCCCCEEECCCCCEEEECCEEEECCCCHHEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-leucine [Periplasm]; H2O [C]

Specific reaction: ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2509433; 2120183; 10984043 [H]