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The map label for this gene is alsR [H]

Identifier: 121610689

GI number: 121610689

Start: 4159041

End: 4159919

Strand: Direct

Name: alsR [H]

Synonym: Veis_3766

Alternate gene names: 121610689

Gene position: 4159041-4159919 (Clockwise)

Preceding gene: 121610683

Following gene: 121610703

Centisome position: 74.71

GC content: 59.84

Gene sequence:

>879_bases
ATGATCGAGCTCCAGAAACTCCACTATTTCGTCACCGTTGCACAGACGCTGAACGTTGGAAAAGCGGCAACGCTGCTGCA
CATATCGCAATCACCGCTGAGTCGTCAGATCATTGCCCTGGAGGAGCGACTGGGAACGGCCCTCTTCTCCCGCGAGCGAA
AGCGGCTTCAACTGACGGATGCGGGTCGGCAGTTTCTGGACGAGGCAAAGGCCCTGATCGAGCATGCGCAGCAACTGGAA
GATCGCATCCGGGATGAGGCGGAGGGGAAGACGGGCGCCATGACGCTTGGCTTCGTGGAAGGTGCCATTCATGTGGGGGC
CCTGCAGACGGCCATCAAACGCTTCTTGAATGTCGCGCCACAAGCCAGGATCGAACTGAAGAACCTGCGCTCGCGACAGC
AGTTCGAGGCATTGCAGTTCGGCGGAATCGATGTCGGCTTCACCTATTCACCGCCCGTGCGCAGCAGCACGCTTGTCGCG
CAACAGATCGCGGATGAAGGATTTGCTGTCGCGATGCCCAGAAATCATCCGCTTGCCCAGGGGCGTTTCGATCCACGCAA
GTTGGATGGGGAGGCATTCATCGCCCTTCCCGAGAAAGACTCCCCGGAGGCGCGTCTGAGCTTGATGGGCGCGTGCGCAA
GCGCCGGCTTCATCCCCAACGTTCGGTTCGAAGCGGCAGAGCCGTCCGTCGTGCTTGGACTCGTGGATGCAGGAGTTGGA
CTCGCGATCGTTCAGCAAAGTCTTGGCAAGACGCCTCGCAGGGGAATCGTGCTGCGCCCGCTGCCATCCTCATTTCCCAT
GAGAGCCCAGATATTCAGGGTGACAAGGAAAACCGTACGTCCCCTTGTCGCACGGTTTCTCGGCAGCCAGAAGGCCTGA

Upstream 100 bases:

>100_bases
CGGCGAATTCAATTGAGTAACCTTGTTTCGAACGATTCTTTGCGTAATGGATAAGATTGTCTATGTCTGTTTTTGCATCT
TATGAGACGTAGAAGGTCTG

Downstream 100 bases:

>100_bases
GCTGCTGTTGCCGGATGCGTTCTGGCCTCGGAGGCTGGGCGGCAGAAGGTCAAATTTTTGTCGGCATGAGTCAGAGGCGG
CCGTTGATCGGGGGCTACGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MIELQKLHYFVTVAQTLNVGKAATLLHISQSPLSRQIIALEERLGTALFSRERKRLQLTDAGRQFLDEAKALIEHAQQLE
DRIRDEAEGKTGAMTLGFVEGAIHVGALQTAIKRFLNVAPQARIELKNLRSRQQFEALQFGGIDVGFTYSPPVRSSTLVA
QQIADEGFAVAMPRNHPLAQGRFDPRKLDGEAFIALPEKDSPEARLSLMGACASAGFIPNVRFEAAEPSVVLGLVDAGVG
LAIVQQSLGKTPRRGIVLRPLPSSFPMRAQIFRVTRKTVRPLVARFLGSQKA

Sequences:

>Translated_292_residues
MIELQKLHYFVTVAQTLNVGKAATLLHISQSPLSRQIIALEERLGTALFSRERKRLQLTDAGRQFLDEAKALIEHAQQLE
DRIRDEAEGKTGAMTLGFVEGAIHVGALQTAIKRFLNVAPQARIELKNLRSRQQFEALQFGGIDVGFTYSPPVRSSTLVA
QQIADEGFAVAMPRNHPLAQGRFDPRKLDGEAFIALPEKDSPEARLSLMGACASAGFIPNVRFEAAEPSVVLGLVDAGVG
LAIVQQSLGKTPRRGIVLRPLPSSFPMRAQIFRVTRKTVRPLVARFLGSQKA
>Mature_292_residues
MIELQKLHYFVTVAQTLNVGKAATLLHISQSPLSRQIIALEERLGTALFSRERKRLQLTDAGRQFLDEAKALIEHAQQLE
DRIRDEAEGKTGAMTLGFVEGAIHVGALQTAIKRFLNVAPQARIELKNLRSRQQFEALQFGGIDVGFTYSPPVRSSTLVA
QQIADEGFAVAMPRNHPLAQGRFDPRKLDGEAFIALPEKDSPEARLSLMGACASAGFIPNVRFEAAEPSVVLGLVDAGVG
LAIVQQSLGKTPRRGIVLRPLPSSFPMRAQIFRVTRKTVRPLVARFLGSQKA

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=291, Percent_Identity=30.5841924398625, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788887, Length=288, Percent_Identity=31.25, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=29.4820717131474, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI145693105, Length=261, Percent_Identity=28.735632183908, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790399, Length=271, Percent_Identity=25.4612546125461, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI157672245, Length=234, Percent_Identity=28.6324786324786, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788481, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081904, Length=210, Percent_Identity=29.5238095238095, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787601, Length=291, Percent_Identity=24.0549828178694, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788296, Length=233, Percent_Identity=27.0386266094421, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=27.6, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=25, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31997; Mature: 31997

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELQKLHYFVTVAQTLNVGKAATLLHISQSPLSRQIIALEERLGTALFSRERKRLQLTD
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHH
AGRQFLDEAKALIEHAQQLEDRIRDEAEGKTGAMTLGFVEGAIHVGALQTAIKRFLNVAP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
QARIELKNLRSRQQFEALQFGGIDVGFTYSPPVRSSTLVAQQIADEGFAVAMPRNHPLAQ
HHHHHHHHHHHHHHHHHHHCCCEEECEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCC
GRFDPRKLDGEAFIALPEKDSPEARLSLMGACASAGFIPNVRFEAAEPSVVLGLVDAGVG
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEHHCCCH
LAIVQQSLGKTPRRGIVLRPLPSSFPMRAQIFRVTRKTVRPLVARFLGSQKA
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELQKLHYFVTVAQTLNVGKAATLLHISQSPLSRQIIALEERLGTALFSRERKRLQLTD
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHH
AGRQFLDEAKALIEHAQQLEDRIRDEAEGKTGAMTLGFVEGAIHVGALQTAIKRFLNVAP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
QARIELKNLRSRQQFEALQFGGIDVGFTYSPPVRSSTLVAQQIADEGFAVAMPRNHPLAQ
HHHHHHHHHHHHHHHHHHHCCCEEECEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCC
GRFDPRKLDGEAFIALPEKDSPEARLSLMGACASAGFIPNVRFEAAEPSVVLGLVDAGVG
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEHHCCCH
LAIVQQSLGKTPRRGIVLRPLPSSFPMRAQIFRVTRKTVRPLVARFLGSQKA
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]