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The map label for this gene is serS

Identifier: 121610578

GI number: 121610578

Start: 4037576

End: 4038892

Strand: Direct

Name: serS

Synonym: Veis_3651

Alternate gene names: 121610578

Gene position: 4037576-4038892 (Clockwise)

Preceding gene: 121610577

Following gene: 121610579

Centisome position: 72.53

GC content: 65.91

Gene sequence:

>1317_bases
ATGCTCGACATCCTCCTGCTCCGCAAAGACCCGGCCAGCGCCATCGCGCGCCTGGAAACCCGGCAAAAGCCCCAGCCCTT
CCTGAACCTGTCAGCCTTCCAAGCCCTGGAAGCCGAGCGCAAGACACTGCAAACCCGCACCGAGGAACTGCAATCGCGGC
GCAACCAACTGTCCAGGCAAATCGGCATCAGCCTGGGCCAGGGCGACCCGGGCAGCGCAGACACCGCCCGGGCACAGGTG
GCGGCCTCGAAACTGGAATTGGCGCAATCGGCCGCCCGCCTGGAGCAGATCCAGGCCGAACTGCAAACCATGCTGGAAGC
CGTGCCCAACCTGCCGCACGACAGCGTGCCGGTCGGCGCCGACGCCTCCGGCAACATCGAACTGCGCCGCTGGGGCCAGC
CGGCCAGCCCGGCCTTCGCCCTGAAAGACCATGTCGATATAGGCCGCCCGCTGGGCCTGGACTTGGACCTGGGCGTCAAG
CTCTCGGGCGCGCGCTTTGCGGTGATGAAAGGCCAGATCGCCCGCCTGCACCGTGCCCTGGCCCAATTCATGCTCGACGT
GCAAACCGGCGAACATGGCTACACCGAATGCTACGTGCCCTACGCGGTGAACGCCGAATCCCTCAAAGGCACCGGCCAGT
TACCCAAATTCGAAAGCGACCTGTTCTCCACCAAAAAAGGCGGCCAGGACGGCGAGCCCGTGCCCGACAACACAGCGCTG
TACCTGATCCCGACCAGCGAAGTACCGCTGACCAACTTCGTGCGCGGCCTGGTGCTGACCGAGGCCGAATTGCCCATCAG
GCTCACCGCCCACACGCCCTGCTTTCGCTCCGAAGCCGGCAGCTACGGCCGCGACACACGCGGCATGATCCGCCAGCACC
AGTTCGACAAAGTCGAGATGGTGCAGATCGTGCACCCGGCCACCAGCTACCAGGCCCTGGAAGAAATGACCGGCCACGCC
GAGGCCCTGCTGCAAAAGCTGGGCCTGCCCTACCGCGTGATGAGCCTGTGCACCGGCGACATGGGCTTTGGCGCCGCCAA
GACCTACGACCTGGAAGTCTGGCTGCCGGCACAAAACAGCTACCGCGAAATCAGTTCGGTGAGCAACTGCGAGGCCTTCC
AGGCGCGCCGCCTGCAAGCGCGCTTCAAGAACGCGCAAGGCAAGAACGAGCCCGTGCACACCCTCAACGGCTCGGGCCTG
GCCGTGGGCCGCACGCTGGTGGCGCTGCTGGAAAATTACCAGCAAGCCGACGGCAGCGTAACCATCCCGCCCGCGCTGCG
CCCCTACATGGCCGGCATCGCCGCGCTCAGACCCTGA

Upstream 100 bases:

>100_bases
GTGAAAGCGGCCAGCAGCGCGCATCGGCATCTGTCCGGTGCGACGCCTGCCGCCCCGGCCACGCCCCGGCCAGCCTGACC
CGAGCCCCTAAAATCGCGAC

Downstream 100 bases:

>100_bases
AGACCGTGGCTATCGTGGCTATAATTGCGGGCTTGGGCACGAGCACCAGGAGAGGTGGCAGAGCGGTCGAATGTACCTGA
CTCGAAATCAGGCGTAGTGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLDILLLRKDPASAIARLETRQKPQPFLNLSAFQALEAERKTLQTRTEELQSRRNQLSRQIGISLGQGDPGSADTARAQV
AASKLELAQSAARLEQIQAELQTMLEAVPNLPHDSVPVGADASGNIELRRWGQPASPAFALKDHVDIGRPLGLDLDLGVK
LSGARFAVMKGQIARLHRALAQFMLDVQTGEHGYTECYVPYAVNAESLKGTGQLPKFESDLFSTKKGGQDGEPVPDNTAL
YLIPTSEVPLTNFVRGLVLTEAELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVHPATSYQALEEMTGHA
EALLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNSYREISSVSNCEAFQARRLQARFKNAQGKNEPVHTLNGSGL
AVGRTLVALLENYQQADGSVTIPPALRPYMAGIAALRP

Sequences:

>Translated_438_residues
MLDILLLRKDPASAIARLETRQKPQPFLNLSAFQALEAERKTLQTRTEELQSRRNQLSRQIGISLGQGDPGSADTARAQV
AASKLELAQSAARLEQIQAELQTMLEAVPNLPHDSVPVGADASGNIELRRWGQPASPAFALKDHVDIGRPLGLDLDLGVK
LSGARFAVMKGQIARLHRALAQFMLDVQTGEHGYTECYVPYAVNAESLKGTGQLPKFESDLFSTKKGGQDGEPVPDNTAL
YLIPTSEVPLTNFVRGLVLTEAELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVHPATSYQALEEMTGHA
EALLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNSYREISSVSNCEAFQARRLQARFKNAQGKNEPVHTLNGSGL
AVGRTLVALLENYQQADGSVTIPPALRPYMAGIAALRP
>Mature_438_residues
MLDILLLRKDPASAIARLETRQKPQPFLNLSAFQALEAERKTLQTRTEELQSRRNQLSRQIGISLGQGDPGSADTARAQV
AASKLELAQSAARLEQIQAELQTMLEAVPNLPHDSVPVGADASGNIELRRWGQPASPAFALKDHVDIGRPLGLDLDLGVK
LSGARFAVMKGQIARLHRALAQFMLDVQTGEHGYTECYVPYAVNAESLKGTGQLPKFESDLFSTKKGGQDGEPVPDNTAL
YLIPTSEVPLTNFVRGLVLTEAELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVHPATSYQALEEMTGHA
EALLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNSYREISSVSNCEAFQARRLQARFKNAQGKNEPVHTLNGSGL
AVGRTLVALLENYQQADGSVTIPPALRPYMAGIAALRP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=477, Percent_Identity=32.7044025157233, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI225579074, Length=442, Percent_Identity=30.0904977375566, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI8923421, Length=440, Percent_Identity=29.5454545454545, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=57.4712643678161, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17539260, Length=432, Percent_Identity=31.4814814814815, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=342, Percent_Identity=29.5321637426901, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=422, Percent_Identity=32.2274881516588, Blast_Score=212, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=393, Percent_Identity=30.2798982188295, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24581334, Length=465, Percent_Identity=30.752688172043, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI17737985, Length=342, Percent_Identity=33.6257309941521, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_VEREI (A1WP10)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_998385.1
- ProteinModelPortal:   A1WP10
- SMR:   A1WP10
- STRING:   A1WP10
- GeneID:   4690657
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_3651
- NMPDR:   fig|391735.5.peg.3367
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   A1WP10
- ProtClustDB:   PRK05431
- BioCyc:   VEIS391735:VEIS_3651-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47820; Mature: 47820

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 299-299 BINDING 398-398

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDILLLRKDPASAIARLETRQKPQPFLNLSAFQALEAERKTLQTRTEELQSRRNQLSRQ
CCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGISLGQGDPGSADTARAQVAASKLELAQSAARLEQIQAELQTMLEAVPNLPHDSVPVGA
HCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DASGNIELRRWGQPASPAFALKDHVDIGRPLGLDLDLGVKLSGARFAVMKGQIARLHRAL
CCCCCEEEEECCCCCCCCEEHHHCCCCCCCCCCCCCCCEEECCCEEEEHHHHHHHHHHHH
AQFMLDVQTGEHGYTECYVPYAVNAESLKGTGQLPKFESDLFSTKKGGQDGEPVPDNTAL
HHHHHHHCCCCCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
YLIPTSEVPLTNFVRGLVLTEAELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEM
EEEECCCCCHHHHHHHHHEEECCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEE
VQIVHPATSYQALEEMTGHAEALLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNS
HHEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEECCCCH
YREISSVSNCEAFQARRLQARFKNAQGKNEPVHTLNGSGLAVGRTLVALLENYQQADGSV
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCE
TIPPALRPYMAGIAALRP
ECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDILLLRKDPASAIARLETRQKPQPFLNLSAFQALEAERKTLQTRTEELQSRRNQLSRQ
CCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGISLGQGDPGSADTARAQVAASKLELAQSAARLEQIQAELQTMLEAVPNLPHDSVPVGA
HCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DASGNIELRRWGQPASPAFALKDHVDIGRPLGLDLDLGVKLSGARFAVMKGQIARLHRAL
CCCCCEEEEECCCCCCCCEEHHHCCCCCCCCCCCCCCCEEECCCEEEEHHHHHHHHHHHH
AQFMLDVQTGEHGYTECYVPYAVNAESLKGTGQLPKFESDLFSTKKGGQDGEPVPDNTAL
HHHHHHHCCCCCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
YLIPTSEVPLTNFVRGLVLTEAELPIRLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEM
EEEECCCCCHHHHHHHHHEEECCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEE
VQIVHPATSYQALEEMTGHAEALLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNS
HHEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEECCCCH
YREISSVSNCEAFQARRLQARFKNAQGKNEPVHTLNGSGLAVGRTLVALLENYQQADGSV
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCE
TIPPALRPYMAGIAALRP
ECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA