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The map label for this gene is ligA [H]

Identifier: 121610428

GI number: 121610428

Start: 3868784

End: 3869797

Strand: Direct

Name: ligA [H]

Synonym: Veis_3497

Alternate gene names: 121610428

Gene position: 3868784-3869797 (Clockwise)

Preceding gene: 121610423

Following gene: 121610430

Centisome position: 69.5

GC content: 68.34

Gene sequence:

>1014_bases
ATGTTAACCAGCGCCGTCCACTTGGCGACGCGGGATAACCCCGGTGGTGGCGCGCATCTGTCCTTGCGGGGCGGTGGCCC
GTCTTCCAAGCCGCTGCCGGCTGTGATAGAACAGGCCGTCAGCGCATGGTATTCAAGTACAGTTTGCTACATATTCAATA
GCATCATCATGGAGCGCAGAAAGTTCCTGGCCTGGTGGGCGCTCGCCGCGCTGCCCGTTCGGGCGGCCGATGCCCCGGCC
CTGCTGCTGGCCAATGTGTACCGGCCCGGCCTGCCGCTGGCCGACTACTGGGTGAGCGAAAAGTATGACGGCGTGCGCGG
CTACTGGGACGGTCGCGCGCTGCGCACCCGCAGCGGTGAAACCGTGGCGGCACCTGCCTGGTTCACGGCCGGTTGGCCCG
GCACGGCGCTGGATGGCGAACTGTGGGCCGGGCGCGGACGGTTTGGCCATGCGCAGTCGACCACGCGGCAGCAGCAGGCC
GATGACAACGCATGGCGCTCCATGCGGTTCATGGTGTTTGACCTGCCCCGGCATGGGGGCAGGTTCGATCAGAGGCTCCC
GGCGCTCAAGGCCCTGGTCGCAAGCATCGGGCAGCCCTGGGTGCAGGCCGTGCCGCAACAGCGCGTCGCCACCGATGCCG
CGCTGCAGGCATTGCTGCAACGCACGGTGCGCGCCGGCGGCGAGGGCCTGATGCTGCACCGGGGCGCTTCGCTGTACCAA
TCAGGCCGCAACGATGATCTGCTCAAGCTCAAGACGCATGAAGACGCCGAGGCCCGCGTGCTCGCCCACCTGCCTGGCAA
GGGCCGCCATGCCGGGCGCCTGGGGGCGCTGCTGGTGGCCATGCCCTCGGGCCAGCGCTTCAAGCTGGGGTCGGGTTTCA
GCGATGCGCAGCGGGCCGATCCGCCACCGGTGGGCAGTTGGGTCACCTACCGGTTTCGCGGCCTGCATGAAAGCGGCCTG
CCGCGCTTTGCCAGCTTTGTGCGAGTGCGGGAAGACATGCCGCCCGACCGCTGA

Upstream 100 bases:

>100_bases
TTCCATCTTTCTGTCCCCTGTAGAAATCCGCACGCTACGCCTCGTTGCGCATTTTTCATCCATTCATCGGGCGTGGGGGT
CGAGCGGCCGGTCTGGTTCG

Downstream 100 bases:

>100_bases
TCAGGACGCCTTGCGGGCAGCCGCTGCACGGGATGCCCGGTGACCGTGGGGCCGGCGCCGCAGTGTCAGTGTCTATGGGT
GGCGCGGCCCGCCAGCGCGT

Product: DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MLTSAVHLATRDNPGGGAHLSLRGGGPSSKPLPAVIEQAVSAWYSSTVCYIFNSIIMERRKFLAWWALAALPVRAADAPA
LLLANVYRPGLPLADYWVSEKYDGVRGYWDGRALRTRSGETVAAPAWFTAGWPGTALDGELWAGRGRFGHAQSTTRQQQA
DDNAWRSMRFMVFDLPRHGGRFDQRLPALKALVASIGQPWVQAVPQQRVATDAALQALLQRTVRAGGEGLMLHRGASLYQ
SGRNDDLLKLKTHEDAEARVLAHLPGKGRHAGRLGALLVAMPSGQRFKLGSGFSDAQRADPPPVGSWVTYRFRGLHESGL
PRFASFVRVREDMPPDR

Sequences:

>Translated_337_residues
MLTSAVHLATRDNPGGGAHLSLRGGGPSSKPLPAVIEQAVSAWYSSTVCYIFNSIIMERRKFLAWWALAALPVRAADAPA
LLLANVYRPGLPLADYWVSEKYDGVRGYWDGRALRTRSGETVAAPAWFTAGWPGTALDGELWAGRGRFGHAQSTTRQQQA
DDNAWRSMRFMVFDLPRHGGRFDQRLPALKALVASIGQPWVQAVPQQRVATDAALQALLQRTVRAGGEGLMLHRGASLYQ
SGRNDDLLKLKTHEDAEARVLAHLPGKGRHAGRLGALLVAMPSGQRFKLGSGFSDAQRADPPPVGSWVTYRFRGLHESGL
PRFASFVRVREDMPPDR
>Mature_337_residues
MLTSAVHLATRDNPGGGAHLSLRGGGPSSKPLPAVIEQAVSAWYSSTVCYIFNSIIMERRKFLAWWALAALPVRAADAPA
LLLANVYRPGLPLADYWVSEKYDGVRGYWDGRALRTRSGETVAAPAWFTAGWPGTALDGELWAGRGRFGHAQSTTRQQQA
DDNAWRSMRFMVFDLPRHGGRFDQRLPALKALVASIGQPWVQAVPQQRVATDAALQALLQRTVRAGGEGLMLHRGASLYQ
SGRNDDLLKLKTHEDAEARVLAHLPGKGRHAGRLGALLVAMPSGQRFKLGSGFSDAQRADPPPVGSWVTYRFRGLHESGL
PRFASFVRVREDMPPDR

Specific function: Catalyzes efficient strand joining on a single nicked DNA [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF01068 DNA_ligase_A_M [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 36894; Mature: 36894

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSAVHLATRDNPGGGAHLSLRGGGPSSKPLPAVIEQAVSAWYSSTVCYIFNSIIMERR
CCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLAWWALAALPVRAADAPALLLANVYRPGLPLADYWVSEKYDGVRGYWDGRALRTRSGE
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEECCCEEEECCCC
TVAAPAWFTAGWPGTALDGELWAGRGRFGHAQSTTRQQQADDNAWRSMRFMVFDLPRHGG
EEECCCEEECCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHEEEEEEECCCCCC
RFDQRLPALKALVASIGQPWVQAVPQQRVATDAALQALLQRTVRAGGEGLMLHRGASLYQ
CHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SGRNDDLLKLKTHEDAEARVLAHLPGKGRHAGRLGALLVAMPSGQRFKLGSGFSDAQRAD
CCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHCCC
PPPVGSWVTYRFRGLHESGLPRFASFVRVREDMPPDR
CCCCCCCHHHEEECCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLTSAVHLATRDNPGGGAHLSLRGGGPSSKPLPAVIEQAVSAWYSSTVCYIFNSIIMERR
CCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLAWWALAALPVRAADAPALLLANVYRPGLPLADYWVSEKYDGVRGYWDGRALRTRSGE
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEECCCEEEECCCC
TVAAPAWFTAGWPGTALDGELWAGRGRFGHAQSTTRQQQADDNAWRSMRFMVFDLPRHGG
EEECCCEEECCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHEEEEEEECCCCCC
RFDQRLPALKALVASIGQPWVQAVPQQRVATDAALQALLQRTVRAGGEGLMLHRGASLYQ
CHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SGRNDDLLKLKTHEDAEARVLAHLPGKGRHAGRLGALLVAMPSGQRFKLGSGFSDAQRAD
CCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHCCC
PPPVGSWVTYRFRGLHESGLPRFASFVRVREDMPPDR
CCCCCCCHHHEEECCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550458; 7542800; 9060431 [H]