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The map label for this gene is oxyR [H]

Identifier: 121610416

GI number: 121610416

Start: 3851607

End: 3852521

Strand: Direct

Name: oxyR [H]

Synonym: Veis_3484

Alternate gene names: 121610416

Gene position: 3851607-3852521 (Clockwise)

Preceding gene: 121610404

Following gene: 121610422

Centisome position: 69.19

GC content: 64.48

Gene sequence:

>915_bases
ATGTCGATTCGCGAACTCGAAAGCCTGGTCGCGATCGCTGACAGCGGCAGCATCACGGCGGCAGCGGAGCGACTGTTTCT
CAGCGTGCCGGCGGTCAGCGCGCAAATTGCCAGCCTGGAAGCGGCGCTGGGCACACCCATGCTGGACAGGAGGTACAAGC
CGGCGCGCCTGAACCCGGCCGGCACGCTGCTGTGCGAGCGTGCACGCGCCGTGTTGAATTCATACCGGCAGTTCTACGAA
ACCGTGGCCAACACAGCCGACCTGGCCGGTGTGCTGGCGGTCGGCGCCTCGCCCACCGTCTTGACCACCGTGATTCCGAA
AACACTGGTGGCATTGCGCAGCGCCCATCCCCGCATCCAGATCCGTATGCAATACGGCCGCGCCTGGAACCTCCTGAAAG
ATTTGCAGCATGGCCAGATCGATGCGCTGATCATCAGCCAGCCCCCGGTCTCGATGGGCAACACCCAATGGACGCAGTTC
GCGCAAGAACCGGTGACGGTGATTGCCCCGCCCGGAGCCAAAGGGCGCAACGATGAATCACTGCTGGCCGAATATCCCTA
CATCCGCTTCGGCCAACGGTTCTGGGTGGCCGACACCATCGCCGCCCATCTGGCCGAACGCGGCATCGTGCCGCAACAGA
TCATGCAAGCCGACTCGCGCGAAGCCATCGCGCTGATGGTGCGCCACGGGCTTGGCGTGTCCATCGTTCCGGAGAGCGAC
CCGCCGCTGTCCAAGCTCTACGGGCTGCGCGAGGTCGCGCTCGGCAAACCGCCGTTGACGCGCAACATCGGCCTGGCGCA
AACCCCCGGCAATCCCAAGCAGGCCCTGATCGATGCGCTGCTGCATGGACTCACGGAAGCCACCGTATCGAGCAGGATGA
AGCCTGCGCCATCCCGCTCACTTGGTGGGACATAA

Upstream 100 bases:

>100_bases
GTGTCATGGGCCGATACAAAAGGAATGCGATGAGGCTAACATCGCAACAAAATAAGTATTTCTGTATTTTTGGAATTTCA
ACTTTCATTTTTCTGAAGTC

Downstream 100 bases:

>100_bases
GGATATTTGATGCCATTGCCCCGCCCCATGACAACGACTATGACAACGACTATGACAACGACTATGACAACTACTGCACC
AACGCCATCAACTTCCCAAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSIRELESLVAIADSGSITAAAERLFLSVPAVSAQIASLEAALGTPMLDRRYKPARLNPAGTLLCERARAVLNSYRQFYE
TVANTADLAGVLAVGASPTVLTTVIPKTLVALRSAHPRIQIRMQYGRAWNLLKDLQHGQIDALIISQPPVSMGNTQWTQF
AQEPVTVIAPPGAKGRNDESLLAEYPYIRFGQRFWVADTIAAHLAERGIVPQQIMQADSREAIALMVRHGLGVSIVPESD
PPLSKLYGLREVALGKPPLTRNIGLAQTPGNPKQALIDALLHGLTEATVSSRMKPAPSRSLGGT

Sequences:

>Translated_304_residues
MSIRELESLVAIADSGSITAAAERLFLSVPAVSAQIASLEAALGTPMLDRRYKPARLNPAGTLLCERARAVLNSYRQFYE
TVANTADLAGVLAVGASPTVLTTVIPKTLVALRSAHPRIQIRMQYGRAWNLLKDLQHGQIDALIISQPPVSMGNTQWTQF
AQEPVTVIAPPGAKGRNDESLLAEYPYIRFGQRFWVADTIAAHLAERGIVPQQIMQADSREAIALMVRHGLGVSIVPESD
PPLSKLYGLREVALGKPPLTRNIGLAQTPGNPKQALIDALLHGLTEATVSSRMKPAPSRSLGGT
>Mature_303_residues
SIRELESLVAIADSGSITAAAERLFLSVPAVSAQIASLEAALGTPMLDRRYKPARLNPAGTLLCERARAVLNSYRQFYET
VANTADLAGVLAVGASPTVLTTVIPKTLVALRSAHPRIQIRMQYGRAWNLLKDLQHGQIDALIISQPPVSMGNTQWTQFA
QEPVTVIAPPGAKGRNDESLLAEYPYIRFGQRFWVADTIAAHLAERGIVPQQIMQADSREAIALMVRHGLGVSIVPESDP
PLSKLYGLREVALGKPPLTRNIGLAQTPGNPKQALIDALLHGLTEATVSSRMKPAPSRSLGGT

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=278, Percent_Identity=28.0575539568345, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788481, Length=242, Percent_Identity=29.7520661157025, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=292, Percent_Identity=24.3150684931507, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788297, Length=243, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=175, Percent_Identity=25.1428571428571, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787806, Length=248, Percent_Identity=23.3870967741935, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788887, Length=243, Percent_Identity=24.6913580246914, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=258, Percent_Identity=26.3565891472868, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32675; Mature: 32544

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRELESLVAIADSGSITAAAERLFLSVPAVSAQIASLEAALGTPMLDRRYKPARLNPA
CCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCHH
GTLLCERARAVLNSYRQFYETVANTADLAGVLAVGASPTVLTTVIPKTLVALRSAHPRIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEE
IRMQYGRAWNLLKDLQHGQIDALIISQPPVSMGNTQWTQFAQEPVTVIAPPGAKGRNDES
EEEECCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCHH
LLAEYPYIRFGQRFWVADTIAAHLAERGIVPQQIMQADSREAIALMVRHGLGVSIVPESD
HHHHCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCEEEECCCC
PPLSKLYGLREVALGKPPLTRNIGLAQTPGNPKQALIDALLHGLTEATVSSRMKPAPSRS
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LGGT
CCCC
>Mature Secondary Structure 
SIRELESLVAIADSGSITAAAERLFLSVPAVSAQIASLEAALGTPMLDRRYKPARLNPA
CHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCHH
GTLLCERARAVLNSYRQFYETVANTADLAGVLAVGASPTVLTTVIPKTLVALRSAHPRIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEE
IRMQYGRAWNLLKDLQHGQIDALIISQPPVSMGNTQWTQFAQEPVTVIAPPGAKGRNDES
EEEECCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCHH
LLAEYPYIRFGQRFWVADTIAAHLAERGIVPQQIMQADSREAIALMVRHGLGVSIVPESD
HHHHCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCEEEECCCC
PPLSKLYGLREVALGKPPLTRNIGLAQTPGNPKQALIDALLHGLTEATVSSRMKPAPSRS
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LGGT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]