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The map label for this gene is serA [H]

Identifier: 121609852

GI number: 121609852

Start: 3248970

End: 3249941

Strand: Direct

Name: serA [H]

Synonym: Veis_2905

Alternate gene names: 121609852

Gene position: 3248970-3249941 (Clockwise)

Preceding gene: 121609851

Following gene: 121609853

Centisome position: 58.36

GC content: 68.93

Gene sequence:

>972_bases
ATGACCACCATCTTCGTTACCGCACCCCGGCTGGCCGCAGCCGGGGTGGATCTGCTGGCCCAAGCCGGCGCCCGCGTGTT
CTATTTGTCCCGCTCCGACGACGCCCGGGAGGTGGAGCGCATCATGGCCTCGGAGTCGATCGACGCCGTCATTTCGCGCA
CCGTCCCGCTATCGGCCAGGGCCATTGCATCTTGCCCGGCGCTGAAGGTGATATCCAAGCACGGCGTGGGGGTCGGCAAC
ATCGACGTGGATGCGGCCACGCGGCGCGGCATCCCGGTCTACATCACGCCCGGGGCCAACGCGCAGTCGGTGGCCGAACT
GACCCTGGGGCTGATGTTCGCAGCGGCGCGGCGCATCGGCTGGATGGATGCCGAACTGCATGCGGGCCGCTGGTCGCGTG
CGCAAGACGGCGTGCAACTGTGCGGCAAGACGCTGGGCCTGGTCGGCTTCGGGCAGATCGGCCAGCGCGTCGCGACCGTA
TGCCTGGCATTGGGCATGCGGGTCGTCGCGTTCGATCCGGCATTCAAGGACGGCCCTGGCCCGGTCGATGGCGTAGCGCT
GCTGCCGACACTGGCCGAGTTGCTGCCGCTGGCCGATGTGCTGAGCCTGCATGTGCCGCTCAACCAGCACACATGCAAAC
TGCTGGGCGCCGCAGAGTTCGGCCGGATGCCGCGCGGCGCAATCCTGGTCAACACGGCACGCGGCGAGGTCGTGGACGAG
CCAGCCCTGCTGGCGGCCCTGCAAAGCGGCCAGCTCTACGCTGCGGCGCTGGACACCATGGCCGTCGAGCCGCTGCCGGC
CGACAGCCCGCTGACGAAGATTCCGAACCTCGTGCTCACGCCGCATGTGGGCGGATCGACGCCGGCGGCATTGGCCACGG
TGGCCAGCGCCGCTGCCCGCAATGTGTTGGGCTGGCTGCAAGGCCGGCCGGTCGAACGCTCCGCGTGCGTCAATCCACAG
GTTCTTTCCTGA

Upstream 100 bases:

>100_bases
GCCCCCTGCCTGCGGACAGGGCGCAACGGGTCTTGCCCGGCGCCAAAGACGCTGCGGGGAGCGTTCCACTTCATTTTTTG
CGCAGCCACATCCGATTGTC

Downstream 100 bases:

>100_bases
GCATTGCCTGCCCCCGGCGCCGGTCTTGTGCGCTACGACCGATCGGCGCCCACCAGGGTCGATCGGATCGGTCCATTCCA
CCCATTCGGCCCATCCGCCT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTTIFVTAPRLAAAGVDLLAQAGARVFYLSRSDDAREVERIMASESIDAVISRTVPLSARAIASCPALKVISKHGVGVGN
IDVDAATRRGIPVYITPGANAQSVAELTLGLMFAAARRIGWMDAELHAGRWSRAQDGVQLCGKTLGLVGFGQIGQRVATV
CLALGMRVVAFDPAFKDGPGPVDGVALLPTLAELLPLADVLSLHVPLNQHTCKLLGAAEFGRMPRGAILVNTARGEVVDE
PALLAALQSGQLYAAALDTMAVEPLPADSPLTKIPNLVLTPHVGGSTPAALATVASAAARNVLGWLQGRPVERSACVNPQ
VLS

Sequences:

>Translated_323_residues
MTTIFVTAPRLAAAGVDLLAQAGARVFYLSRSDDAREVERIMASESIDAVISRTVPLSARAIASCPALKVISKHGVGVGN
IDVDAATRRGIPVYITPGANAQSVAELTLGLMFAAARRIGWMDAELHAGRWSRAQDGVQLCGKTLGLVGFGQIGQRVATV
CLALGMRVVAFDPAFKDGPGPVDGVALLPTLAELLPLADVLSLHVPLNQHTCKLLGAAEFGRMPRGAILVNTARGEVVDE
PALLAALQSGQLYAAALDTMAVEPLPADSPLTKIPNLVLTPHVGGSTPAALATVASAAARNVLGWLQGRPVERSACVNPQ
VLS
>Mature_322_residues
TTIFVTAPRLAAAGVDLLAQAGARVFYLSRSDDAREVERIMASESIDAVISRTVPLSARAIASCPALKVISKHGVGVGNI
DVDAATRRGIPVYITPGANAQSVAELTLGLMFAAARRIGWMDAELHAGRWSRAQDGVQLCGKTLGLVGFGQIGQRVATVC
LALGMRVVAFDPAFKDGPGPVDGVALLPTLAELLPLADVLSLHVPLNQHTCKLLGAAEFGRMPRGAILVNTARGEVVDEP
ALLAALQSGQLYAAALDTMAVEPLPADSPLTKIPNLVLTPHVGGSTPAALATVASAAARNVLGWLQGRPVERSACVNPQV
LS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=38.3275261324042, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI145580578, Length=297, Percent_Identity=34.3434343434343, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4557499, Length=297, Percent_Identity=34.3434343434343, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI61743967, Length=298, Percent_Identity=33.2214765100671, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI4557497, Length=298, Percent_Identity=33.2214765100671, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI145580575, Length=297, Percent_Identity=34.3434343434343, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI6912396, Length=321, Percent_Identity=30.5295950155763, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1789279, Length=284, Percent_Identity=36.2676056338028, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082289, Length=270, Percent_Identity=35.9259259259259, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1787645, Length=273, Percent_Identity=30.4029304029304, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081824, Length=149, Percent_Identity=35.5704697986577, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788660, Length=244, Percent_Identity=29.0983606557377, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=35.1351351351351, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=298, Percent_Identity=28.1879194630872, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=293, Percent_Identity=33.7883959044369, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322116, Length=299, Percent_Identity=32.4414715719064, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324055, Length=291, Percent_Identity=28.1786941580756, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=291, Percent_Identity=27.8350515463918, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921140, Length=298, Percent_Identity=36.5771812080537, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646446, Length=296, Percent_Identity=33.7837837837838, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646448, Length=296, Percent_Identity=33.7837837837838, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646452, Length=296, Percent_Identity=33.7837837837838, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646450, Length=296, Percent_Identity=33.7837837837838, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI62472511, Length=296, Percent_Identity=33.7837837837838, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=34.4827586206897, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24585516, Length=320, Percent_Identity=30.3125, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=30.5031446540881, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=30.5031446540881, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=30.5031446540881, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=30.5031446540881, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=30.5031446540881, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571528, Length=319, Percent_Identity=31.3479623824451, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33478; Mature: 33347

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIFVTAPRLAAAGVDLLAQAGARVFYLSRSDDAREVERIMASESIDAVISRTVPLSAR
CEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
AIASCPALKVISKHGVGVGNIDVDAATRRGIPVYITPGANAQSVAELTLGLMFAAARRIG
HHHCCCHHHHHHHCCCCCCCEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
WMDAELHAGRWSRAQDGVQLCGKTLGLVGFGQIGQRVATVCLALGMRVVAFDPAFKDGPG
CCCCHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
PVDGVALLPTLAELLPLADVLSLHVPLNQHTCKLLGAAEFGRMPRGAILVNTARGEVVDE
CCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCHHHCCCCCCEEEEECCCCCCCCC
PALLAALQSGQLYAAALDTMAVEPLPADSPLTKIPNLVLTPHVGGSTPAALATVASAAAR
HHHHHHHHCCCEEEEHHHHHHCCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHH
NVLGWLQGRPVERSACVNPQVLS
HHHHHHCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
TTIFVTAPRLAAAGVDLLAQAGARVFYLSRSDDAREVERIMASESIDAVISRTVPLSAR
EEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
AIASCPALKVISKHGVGVGNIDVDAATRRGIPVYITPGANAQSVAELTLGLMFAAARRIG
HHHCCCHHHHHHHCCCCCCCEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
WMDAELHAGRWSRAQDGVQLCGKTLGLVGFGQIGQRVATVCLALGMRVVAFDPAFKDGPG
CCCCHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
PVDGVALLPTLAELLPLADVLSLHVPLNQHTCKLLGAAEFGRMPRGAILVNTARGEVVDE
CCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCHHHCCCCCCEEEEECCCCCCCCC
PALLAALQSGQLYAAALDTMAVEPLPADSPLTKIPNLVLTPHVGGSTPAALATVASAAAR
HHHHHHHHCCCEEEEHHHHHHCCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHH
NVLGWLQGRPVERSACVNPQVLS
HHHHHHCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]