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The map label for this gene is ada [H]

Identifier: 121609516

GI number: 121609516

Start: 2891341

End: 2893086

Strand: Direct

Name: ada [H]

Synonym: Veis_2560

Alternate gene names: 121609516

Gene position: 2891341-2893086 (Clockwise)

Preceding gene: 121609506

Following gene: 121609517

Centisome position: 51.94

GC content: 71.53

Gene sequence:

>1746_bases
ATGTCCGAAAACAGCCAGTGCCGGCGCCGGCCAGTTCTTATGATGCGGCCCATGACACAGCCCCCACAGCCTGCTTGCGC
ACCGGCCGCAGACGCCTCGGATGAGGGCCGCTACCTGGCGCTGCTGGCCCGCGACGCGCGCTTTGACGGGCATTTTTTCA
CCGGCGTGACATCCACCGGCATCTACTGCCGCCCGGTCTGCGCCGTGCGCACACCCCGGCGTGACAACTGCCGCTTCTTC
ACGCTGGCCGCCCAGGCCGAACGGGCCGGCTTTCGCCCCTGTCTGCGCTGCCGGCCCGAACTGGCGCCCCAGGCGCTGCG
CTGGTCGCTGCAGGACGCCAGCGCCGTCTTGGTGCAACAGGCCGTGCGCCTGCTCGACGCCCCCGAACTGTGGGCGCCAG
CGCCGCAACAGGCCGCTCAGGCCGCTCAGGCCGGCCATACCGGCGCCGTCGCCCGGCTGGCGCAACGCCTGGGCGTGAGC
GACCGCCACCTGCGCCGCATTTTCGAGGCCGCCCTGGGCGTATCGCCGCTGCAATACCTGCAAACGCGGCGGCTGCTGAC
CGCCAAGCAGTTGCTGACCGACACCACGATGCCCGTCACCGACATAGCCCTGGCCAGCGGCTTTGCCAGCCTGCGCCGCT
TCAACGCCGCGTTTGCCGGGCATTACCGTCTGAACCCCACACAATTGCGCCGCAGCGGCGCCGATACCGCTGCACCCACG
CAATGCAGTGACGCCAGCGTCATCACACCCGCGCAACGCAGCGGCGCCAGCGCCATACCAATGCAACGCAGTGACACCAA
TGCCACAGCCACGCAACGCAGTGGCACCAACGCCACTGCGGGCCACACCGGCGAACTGCGCCTGGCCTGGCGCCCGCCGC
TGGACGTGGCTGCGCTGCTGGCATTTTTTGCCCGCCGGCAGTTGCACGGCGTGGAGTGGGTGCTGCCGGACGGCGCCGGC
CCGATCCTGCGGCGCACCGTGCGGCTGGCGCCCGGCTGCACCGGGCAGCCCCGGGAGATCATCGGCTGGATCAGCGCCCG
CTTCGATGGCAGCCGCCATCTGCTGCTGTTGCAGGCCAGCGACAGCCTGTACCCGGTGTTGCCACTCGTGATCCGCCGGG
TGCGCGCGCTGCTGGACCTCGATGCCGACCCTGCCGCCATCAACGCCGTGCTGCACCCGCATTTTCCGCAAGGCGATGGC
TTGCGGCTGCCCGGCGCGTTTGACGGCTTCGAACTGGCCGTGCGGGCCGTGCTGGGCCAGCAAGTCACGCTGGCAGCGGC
GCGCACGCTCGGCCAGCGCCTGGTCGAGCGGCTGGGCCAGACCATTGCCACCCCCTGGCCCGAACTCCAGCGCCTGTTCC
CCGCCCCCGCCACGCTGGCCGCCACCGATGGCGCGGTGCTCGGCCAGATGGGCATCGTGCGCCAGCGCCAAGCCGCCATC
GTGGCACTGGCGCGCGCGGTCGACGGCGGCCAGTTGGCCCTGCATGACGGCGCCGATCCGGAAAAAACCACGGCCGCCCT
GTGCGCCCTGCCCGGCATTGGCGACTGGACCGCGCAATACATCGCGATGCGGGTGCTGCGCTGGCCCGATGCGTTTCCGT
CCGGCGATGTCGCGCTGCACAAGGCGCTGGGCCTGCAAGGGCAGAAAAACCCGGCCCGCGCCGCCACCGCCGCCGCGCAG
GCTTGGCGCCCCTGGCGCAGCTACGCGCTGCTACGGGCCTGGGCCGGCGCAGCCGCGCAGGCATGA

Upstream 100 bases:

>100_bases
GCTGCGCGATGCGCCTTGCGCTGCGCTCCGATGGCTGCGCGCAGCCTACGACATCTGATCCGTGACGCGACAGTACCCAT
GGCTTGACGCCTGTAGTCAC

Downstream 100 bases:

>100_bases
GACATCCTGTGTCAACCCCACCCCGCCGTTTTGCCAGGCCATCGAGCGCCGCCCGGCCGCCCGAAGGTGCTCATACCGTA
GCCAAAGGCGAAGGCACTCC

Product: Ada metal-binding domain-containing protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MSENSQCRRRPVLMMRPMTQPPQPACAPAADASDEGRYLALLARDARFDGHFFTGVTSTGIYCRPVCAVRTPRRDNCRFF
TLAAQAERAGFRPCLRCRPELAPQALRWSLQDASAVLVQQAVRLLDAPELWAPAPQQAAQAAQAGHTGAVARLAQRLGVS
DRHLRRIFEAALGVSPLQYLQTRRLLTAKQLLTDTTMPVTDIALASGFASLRRFNAAFAGHYRLNPTQLRRSGADTAAPT
QCSDASVITPAQRSGASAIPMQRSDTNATATQRSGTNATAGHTGELRLAWRPPLDVAALLAFFARRQLHGVEWVLPDGAG
PILRRTVRLAPGCTGQPREIIGWISARFDGSRHLLLLQASDSLYPVLPLVIRRVRALLDLDADPAAINAVLHPHFPQGDG
LRLPGAFDGFELAVRAVLGQQVTLAAARTLGQRLVERLGQTIATPWPELQRLFPAPATLAATDGAVLGQMGIVRQRQAAI
VALARAVDGGQLALHDGADPEKTTAALCALPGIGDWTAQYIAMRVLRWPDAFPSGDVALHKALGLQGQKNPARAATAAAQ
AWRPWRSYALLRAWAGAAAQA

Sequences:

>Translated_581_residues
MSENSQCRRRPVLMMRPMTQPPQPACAPAADASDEGRYLALLARDARFDGHFFTGVTSTGIYCRPVCAVRTPRRDNCRFF
TLAAQAERAGFRPCLRCRPELAPQALRWSLQDASAVLVQQAVRLLDAPELWAPAPQQAAQAAQAGHTGAVARLAQRLGVS
DRHLRRIFEAALGVSPLQYLQTRRLLTAKQLLTDTTMPVTDIALASGFASLRRFNAAFAGHYRLNPTQLRRSGADTAAPT
QCSDASVITPAQRSGASAIPMQRSDTNATATQRSGTNATAGHTGELRLAWRPPLDVAALLAFFARRQLHGVEWVLPDGAG
PILRRTVRLAPGCTGQPREIIGWISARFDGSRHLLLLQASDSLYPVLPLVIRRVRALLDLDADPAAINAVLHPHFPQGDG
LRLPGAFDGFELAVRAVLGQQVTLAAARTLGQRLVERLGQTIATPWPELQRLFPAPATLAATDGAVLGQMGIVRQRQAAI
VALARAVDGGQLALHDGADPEKTTAALCALPGIGDWTAQYIAMRVLRWPDAFPSGDVALHKALGLQGQKNPARAATAAAQ
AWRPWRSYALLRAWAGAAAQA
>Mature_580_residues
SENSQCRRRPVLMMRPMTQPPQPACAPAADASDEGRYLALLARDARFDGHFFTGVTSTGIYCRPVCAVRTPRRDNCRFFT
LAAQAERAGFRPCLRCRPELAPQALRWSLQDASAVLVQQAVRLLDAPELWAPAPQQAAQAAQAGHTGAVARLAQRLGVSD
RHLRRIFEAALGVSPLQYLQTRRLLTAKQLLTDTTMPVTDIALASGFASLRRFNAAFAGHYRLNPTQLRRSGADTAAPTQ
CSDASVITPAQRSGASAIPMQRSDTNATATQRSGTNATAGHTGELRLAWRPPLDVAALLAFFARRQLHGVEWVLPDGAGP
ILRRTVRLAPGCTGQPREIIGWISARFDGSRHLLLLQASDSLYPVLPLVIRRVRALLDLDADPAAINAVLHPHFPQGDGL
RLPGAFDGFELAVRAVLGQQVTLAAARTLGQRLVERLGQTIATPWPELQRLFPAPATLAATDGAVLGQMGIVRQRQAAIV
ALARAVDGGQLALHDGADPEKTTAALCALPGIGDWTAQYIAMRVLRWPDAFPSGDVALHKALGLQGQKNPARAATAAAQA
WRPWRSYALLRAWAGAAAQA

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=288, Percent_Identity=34.7222222222222, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788542, Length=236, Percent_Identity=29.6610169491525, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 62528; Mature: 62397

Theoretical pI: Translated: 11.17; Mature: 11.17

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENSQCRRRPVLMMRPMTQPPQPACAPAADASDEGRYLALLARDARFDGHFFTGVTSTG
CCCCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCC
IYCRPVCAVRTPRRDNCRFFTLAAQAERAGFRPCLRCRPELAPQALRWSLQDASAVLVQQ
CEEEEHHHCCCCCCCCCEEEEEECHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AVRLLDAPELWAPAPQQAAQAAQAGHTGAVARLAQRLGVSDRHLRRIFEAALGVSPLQYL
HHHHHCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
QTRRLLTAKQLLTDTTMPVTDIALASGFASLRRFNAAFAGHYRLNPTQLRRSGADTAAPT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCC
QCSDASVITPAQRSGASAIPMQRSDTNATATQRSGTNATAGHTGELRLAWRPPLDVAALL
CCCCCCEECCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHH
AFFARRQLHGVEWVLPDGAGPILRRTVRLAPGCTGQPREIIGWISARFDGSRHLLLLQAS
HHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECC
DSLYPVLPLVIRRVRALLDLDADPAAINAVLHPHFPQGDGLRLPGAFDGFELAVRAVLGQ
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCCCCCEECCCCCCHHHHHHHHHHCC
QVTLAAARTLGQRLVERLGQTIATPWPELQRLFPAPATLAATDGAVLGQMGIVRQRQAAI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
VALARAVDGGQLALHDGADPEKTTAALCALPGIGDWTAQYIAMRVLRWPDAFPSGDVALH
HHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
KALGLQGQKNPARAATAAAQAWRPWRSYALLRAWAGAAAQA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SENSQCRRRPVLMMRPMTQPPQPACAPAADASDEGRYLALLARDARFDGHFFTGVTSTG
CCCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCC
IYCRPVCAVRTPRRDNCRFFTLAAQAERAGFRPCLRCRPELAPQALRWSLQDASAVLVQQ
CEEEEHHHCCCCCCCCCEEEEEECHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AVRLLDAPELWAPAPQQAAQAAQAGHTGAVARLAQRLGVSDRHLRRIFEAALGVSPLQYL
HHHHHCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
QTRRLLTAKQLLTDTTMPVTDIALASGFASLRRFNAAFAGHYRLNPTQLRRSGADTAAPT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCC
QCSDASVITPAQRSGASAIPMQRSDTNATATQRSGTNATAGHTGELRLAWRPPLDVAALL
CCCCCCEECCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHH
AFFARRQLHGVEWVLPDGAGPILRRTVRLAPGCTGQPREIIGWISARFDGSRHLLLLQAS
HHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECC
DSLYPVLPLVIRRVRALLDLDADPAAINAVLHPHFPQGDGLRLPGAFDGFELAVRAVLGQ
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCCCCCEECCCCCCHHHHHHHHHHCC
QVTLAAARTLGQRLVERLGQTIATPWPELQRLFPAPATLAATDGAVLGQMGIVRQRQAAI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
VALARAVDGGQLALHDGADPEKTTAALCALPGIGDWTAQYIAMRVLRWPDAFPSGDVALH
HHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
KALGLQGQKNPARAATAAAQAWRPWRSYALLRAWAGAAAQA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]