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The map label for this gene is cycA [C]

Identifier: 120613400

GI number: 120613400

Start: 5326727

End: 5328136

Strand: Direct

Name: cycA [C]

Synonym: Aave_4773

Alternate gene names: 120613400

Gene position: 5326727-5328136 (Clockwise)

Preceding gene: 120613397

Following gene: 120613401

Centisome position: 99.51

GC content: 69.01

Gene sequence:

>1410_bases
ATGCACACCTGCGCCTCCACCCCTTCCGATCCGGCCCACGCACCGCACCTGAAGAAGGTGCTGGGCACCTTCCAGCTCTG
GGGCATCGCCGTCGGACTGGTGATCTCCGGCGAATACTTCGGCTGGAGCTACGGCTGGGCCAGCGCCGGTACGCTGGGCT
TCCTGGTCGCCACCGTGCTGGTGGCCGCCATGTACACCAGCTTCATCTTCAGCTTCACCGAACTCACCACCGCCATCCCG
CACGCGGGCGGCCCCTTCGCCTATGCGCGGCGCGCCTTCGGGCCGGCGGGCGGCTTCGTGGCGGGCTACGCCACGCTGGT
GGAATTCGTCTTCGCGCCGCCGGCCATCGCGCTGGCCATCGGCGCCTACCTGAACGTGCAGTTCCCGTCCATCAACGCCA
AGACCATCGCCCTGGGCGCCTACGTGGTGTTCATCGGGCTGAACTGGGTGGGCGTGGGCATCGCGGCCACGTTCGAGCTG
ATCGTCACGCTGCTGGCCATCTTCGAGCTGCTGGTGTTCATGGGCGTGGTCAGCCCCGGCTGGTCGTGGGCGAACTTCGC
CCACCTGGGCTGGGCCGGCAGCGACACCTTCAGCGGCGCCACCGTGGCGGGCATCTTCGCGTCCATCCCGTTCGCGATCT
GGTTCTTCCTGGCGATCGAGGGCGCGGCCATGGCCGCCGAGGAAGCGCGTGATCCGCAGCGCACCATTCCACGCGCCTAC
ATCGCCGGCATCCTGACACTGGTGGCGCTGGCCTTCGGCGTGATGGTCATGGCCGGCGGCGTGACCGACTGGCGCCAGCT
CTCCAACATCAACGACCCGCTGCCCCAGGCGATGAAGGCCCTGCTGGGCGCCAACAGCGGCTGGCTGCACATGATGGTGT
GGATCGGCCTCTTCGGGCTGGTGGCCTCGTTCCACGGCATCATCATGGGCTACTCGCGCCAGATCTTCGCGCTGGCGCGC
GCCGGCTACCTGCCCGGTGCCTTCGCCCGGCTCAGCCCGCGCTTCAACACGCCGCACCGCGCCCTGCTGGCGGGCGGCGC
CGTGGGCGTGGCCGCGATCTTCAGCGACGAATGGGTCCAGTTCGGCGGCCAGACGCTCACCGCCAACATCGTCACCATGG
CGGTCTTCGGCGCCATCGTGATGTACATCGTCTCCATGGCCGCGCTGCTGCGCCTGCGCCGCACCGAGCCCGGCATGCAT
CGCCCCTACCGCGCGCCGCTCTACCCCTTCTTTCCCCTGCTGGCGCTGGCCCTGGGCGTGGTGTGCCTGATCGCCATGGT
GTGGTTCAACACCGTGCTGGCAGCGGTGTTTCTCGCGCTGATGGCGCTGTCGTGGTTGTATTACGCTGGCACTGCCAGAC
GCCGCGCGCAGGCCGCGCCCGACGCGCTGCTGGATGCCTCCCCCCGGTAA

Upstream 100 bases:

>100_bases
ACGGCCCGCTTTTTCCGAATCCGGATAGACGCCGGCGGCCCGGAATGGGTGCAATGGCGGCACGTCGTCCGTCGGCTTTC
CGAACCCAGCAAGGCACTCC

Downstream 100 bases:

>100_bases
CGAAGGGATTCCGCCATGCGCTACCACGCCACCCTGGGCGGCCAGGGCCATGTCTTCGACGATCTCCGCCAGGTGATGGC
CCACGCCAGCCCGGCGCGCT

Product: ethanolamine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MHTCASTPSDPAHAPHLKKVLGTFQLWGIAVGLVISGEYFGWSYGWASAGTLGFLVATVLVAAMYTSFIFSFTELTTAIP
HAGGPFAYARRAFGPAGGFVAGYATLVEFVFAPPAIALAIGAYLNVQFPSINAKTIALGAYVVFIGLNWVGVGIAATFEL
IVTLLAIFELLVFMGVVSPGWSWANFAHLGWAGSDTFSGATVAGIFASIPFAIWFFLAIEGAAMAAEEARDPQRTIPRAY
IAGILTLVALAFGVMVMAGGVTDWRQLSNINDPLPQAMKALLGANSGWLHMMVWIGLFGLVASFHGIIMGYSRQIFALAR
AGYLPGAFARLSPRFNTPHRALLAGGAVGVAAIFSDEWVQFGGQTLTANIVTMAVFGAIVMYIVSMAALLRLRRTEPGMH
RPYRAPLYPFFPLLALALGVVCLIAMVWFNTVLAAVFLALMALSWLYYAGTARRRAQAAPDALLDASPR

Sequences:

>Translated_469_residues
MHTCASTPSDPAHAPHLKKVLGTFQLWGIAVGLVISGEYFGWSYGWASAGTLGFLVATVLVAAMYTSFIFSFTELTTAIP
HAGGPFAYARRAFGPAGGFVAGYATLVEFVFAPPAIALAIGAYLNVQFPSINAKTIALGAYVVFIGLNWVGVGIAATFEL
IVTLLAIFELLVFMGVVSPGWSWANFAHLGWAGSDTFSGATVAGIFASIPFAIWFFLAIEGAAMAAEEARDPQRTIPRAY
IAGILTLVALAFGVMVMAGGVTDWRQLSNINDPLPQAMKALLGANSGWLHMMVWIGLFGLVASFHGIIMGYSRQIFALAR
AGYLPGAFARLSPRFNTPHRALLAGGAVGVAAIFSDEWVQFGGQTLTANIVTMAVFGAIVMYIVSMAALLRLRRTEPGMH
RPYRAPLYPFFPLLALALGVVCLIAMVWFNTVLAAVFLALMALSWLYYAGTARRRAQAAPDALLDASPR
>Mature_469_residues
MHTCASTPSDPAHAPHLKKVLGTFQLWGIAVGLVISGEYFGWSYGWASAGTLGFLVATVLVAAMYTSFIFSFTELTTAIP
HAGGPFAYARRAFGPAGGFVAGYATLVEFVFAPPAIALAIGAYLNVQFPSINAKTIALGAYVVFIGLNWVGVGIAATFEL
IVTLLAIFELLVFMGVVSPGWSWANFAHLGWAGSDTFSGATVAGIFASIPFAIWFFLAIEGAAMAAEEARDPQRTIPRAY
IAGILTLVALAFGVMVMAGGVTDWRQLSNINDPLPQAMKALLGANSGWLHMMVWIGLFGLVASFHGIIMGYSRQIFALAR
AGYLPGAFARLSPRFNTPHRALLAGGAVGVAAIFSDEWVQFGGQTLTANIVTMAVFGAIVMYIVSMAALLRLRRTEPGMH
RPYRAPLYPFFPLLALALGVVCLIAMVWFNTVLAAVFLALMALSWLYYAGTARRRAQAAPDALLDASPR

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI7657683, Length=364, Percent_Identity=24.1758241758242, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790653, Length=389, Percent_Identity=24.4215938303342, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082250, Length=379, Percent_Identity=25.065963060686, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=22.1445221445221, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081869, Length=431, Percent_Identity=22.737819025522, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081708, Length=478, Percent_Identity=21.9665271966527, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI2367353, Length=342, Percent_Identity=25.7309941520468, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082023, Length=300, Percent_Identity=22.6666666666667, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=347, Percent_Identity=24.4956772334294, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24667468, Length=437, Percent_Identity=22.6544622425629, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221512776, Length=430, Percent_Identity=23.4883720930233, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24666159, Length=430, Percent_Identity=23.4883720930233, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357367, Length=356, Percent_Identity=25.8426966292135, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281366235, Length=355, Percent_Identity=22.8169014084507, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI116007820, Length=355, Percent_Identity=22.8169014084507, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49979; Mature: 49979

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTCASTPSDPAHAPHLKKVLGTFQLWGIAVGLVISGEYFGWSYGWASAGTLGFLVATVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHH
VAAMYTSFIFSFTELTTAIPHAGGPFAYARRAFGPAGGFVAGYATLVEFVFAPPAIALAI
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHH
GAYLNVQFPSINAKTIALGAYVVFIGLNWVGVGIAATFELIVTLLAIFELLVFMGVVSPG
HHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WSWANFAHLGWAGSDTFSGATVAGIFASIPFAIWFFLAIEGAAMAAEEARDPQRTIPRAY
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IAGILTLVALAFGVMVMAGGVTDWRQLSNINDPLPQAMKALLGANSGWLHMMVWIGLFGL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VASFHGIIMGYSRQIFALARAGYLPGAFARLSPRFNTPHRALLAGGAVGVAAIFSDEWVQ
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
FGGQTLTANIVTMAVFGAIVMYIVSMAALLRLRRTEPGMHRPYRAPLYPFFPLLALALGV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VCLIAMVWFNTVLAAVFLALMALSWLYYAGTARRRAQAAPDALLDASPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure
MHTCASTPSDPAHAPHLKKVLGTFQLWGIAVGLVISGEYFGWSYGWASAGTLGFLVATVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHH
VAAMYTSFIFSFTELTTAIPHAGGPFAYARRAFGPAGGFVAGYATLVEFVFAPPAIALAI
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHH
GAYLNVQFPSINAKTIALGAYVVFIGLNWVGVGIAATFELIVTLLAIFELLVFMGVVSPG
HHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WSWANFAHLGWAGSDTFSGATVAGIFASIPFAIWFFLAIEGAAMAAEEARDPQRTIPRAY
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IAGILTLVALAFGVMVMAGGVTDWRQLSNINDPLPQAMKALLGANSGWLHMMVWIGLFGL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VASFHGIIMGYSRQIFALARAGYLPGAFARLSPRFNTPHRALLAGGAVGVAAIFSDEWVQ
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
FGGQTLTANIVTMAVFGAIVMYIVSMAALLRLRRTEPGMHRPYRAPLYPFFPLLALALGV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VCLIAMVWFNTVLAAVFLALMALSWLYYAGTARRRAQAAPDALLDASPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]