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The map label for this gene is livM [H]

Identifier: 120613379

GI number: 120613379

Start: 5300201

End: 5301196

Strand: Direct

Name: livM [H]

Synonym: Aave_4752

Alternate gene names: 120613379

Gene position: 5300201-5301196 (Clockwise)

Preceding gene: 120613378

Following gene: 120613380

Centisome position: 99.02

GC content: 69.38

Gene sequence:

>996_bases
ATGACGATCTTGCGCAAACATTTCCACCTGCTGCTGGCGCTGGCCTTCGTGCTGGCGATGCCGCTCACCATGCAGTCCGG
GTCGCTGGCCAGCGAGGTGCTGATCTACGGCCTCGCCGCCATGGGCTGCAACCTGCTGCTGGGGCACACGGGGTTGCTGT
CCTTCGGGCAGGGCATCTTCTTCGGGCTGGGCAGCTACACCATCGCCCTCACGCTCACGCGCTGGCCCCTGCCCATGCCG
GTGGCCCTGGCGCTCGCCGTGGTGGCGGGCGCGGTGGGCGCGGCGCTGGTGGGCTGGGTCGCCATCCGGCAGCGCGGCAC
CTATTTCGTGATGCTCACGCTCGCCTTCGCCCAGATGTTCTATTTCCTCGCCTACTCGATGCCAAGTCTGACGGGCGGCG
ACAACGGCCTGATGGACATCCCGCGCCCCTCGCTGGCCGTGGGCGGCTTCACGCTGTGGCCGCTCGCCTCGCCGTGGCAG
TACTACGGCTTCGTCGCCGTGGTGTTCCTGGTGGCCTTCTGGCTGCTGCAGCAGGTGTCGGCCTCCGTGTTCGGCCGCAC
CCTGCTGGCCGTGCGCGACAACGAGGAGCGCGCGGGCGCCATCGGCTACGACCTCAAGCTGCTGAAGCTCCAGGCGTTCG
TGATCTCGGGCGCCGTCACCGGCCTGGCCGGCGCGCTGCACGCCATGATGACCGGCATCGCCCCCCTGGCCAGCGCCGAA
TACCACACGAGCGAGATGATCCTCGTGATGACCGTGATCGGCGGCACCGGCACCCTGCTGGCCTCGCTGCTGGGATCGGC
CTTCTACCTGATCGTGGGCGACTGGCTCTCCACCCTGTGGCCGCGCTGGCTGCTGCTGCTGGGCGTGGTGCTGATGGTCG
TCAGCCTGGGAATGCAGCGCGGCCTCTGGGGCCTGCTCGAATCGGCCTGGGAGCGCCTGCGCGGCGCGAAAGGCCCCTCG
GACGGCGCCCCTGCCGGCACGGGAGACAAAGCATGA

Upstream 100 bases:

>100_bases
TGTGGCCCGAGGGCGCGCGCCTGATGATCTACGTCGCCATGGCCGCCGTGCTGCTGCTGCGCCCGCATGGCCTGCTGGGC
CGCAAAGGATGAACACCGCC

Downstream 100 bases:

>100_bases
GCACCGCCCCCATCCTGCTGGAAGCCATCGGCGTCGAGAAGCGCTACGACAAATTCGCCGCGCTCGCGGGCGTGGACCTG
AAAGTGCGCGCCAACACCGT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTILRKHFHLLLALAFVLAMPLTMQSGSLASEVLIYGLAAMGCNLLLGHTGLLSFGQGIFFGLGSYTIALTLTRWPLPMP
VALALAVVAGAVGAALVGWVAIRQRGTYFVMLTLAFAQMFYFLAYSMPSLTGGDNGLMDIPRPSLAVGGFTLWPLASPWQ
YYGFVAVVFLVAFWLLQQVSASVFGRTLLAVRDNEERAGAIGYDLKLLKLQAFVISGAVTGLAGALHAMMTGIAPLASAE
YHTSEMILVMTVIGGTGTLLASLLGSAFYLIVGDWLSTLWPRWLLLLGVVLMVVSLGMQRGLWGLLESAWERLRGAKGPS
DGAPAGTGDKA

Sequences:

>Translated_331_residues
MTILRKHFHLLLALAFVLAMPLTMQSGSLASEVLIYGLAAMGCNLLLGHTGLLSFGQGIFFGLGSYTIALTLTRWPLPMP
VALALAVVAGAVGAALVGWVAIRQRGTYFVMLTLAFAQMFYFLAYSMPSLTGGDNGLMDIPRPSLAVGGFTLWPLASPWQ
YYGFVAVVFLVAFWLLQQVSASVFGRTLLAVRDNEERAGAIGYDLKLLKLQAFVISGAVTGLAGALHAMMTGIAPLASAE
YHTSEMILVMTVIGGTGTLLASLLGSAFYLIVGDWLSTLWPRWLLLLGVVLMVVSLGMQRGLWGLLESAWERLRGAKGPS
DGAPAGTGDKA
>Mature_330_residues
TILRKHFHLLLALAFVLAMPLTMQSGSLASEVLIYGLAAMGCNLLLGHTGLLSFGQGIFFGLGSYTIALTLTRWPLPMPV
ALALAVVAGAVGAALVGWVAIRQRGTYFVMLTLAFAQMFYFLAYSMPSLTGGDNGLMDIPRPSLAVGGFTLWPLASPWQY
YGFVAVVFLVAFWLLQQVSASVFGRTLLAVRDNEERAGAIGYDLKLLKLQAFVISGAVTGLAGALHAMMTGIAPLASAEY
HTSEMILVMTVIGGTGTLLASLLGSAFYLIVGDWLSTLWPRWLLLLGVVLMVVSLGMQRGLWGLLESAWERLRGAKGPSD
GAPAGTGDKA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=330, Percent_Identity=26.969696969697, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 35190; Mature: 35059

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILRKHFHLLLALAFVLAMPLTMQSGSLASEVLIYGLAAMGCNLLLGHTGLLSFGQGIF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHH
FGLGSYTIALTLTRWPLPMPVALALAVVAGAVGAALVGWVAIRQRGTYFVMLTLAFAQMF
HCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHH
YFLAYSMPSLTGGDNGLMDIPRPSLAVGGFTLWPLASPWQYYGFVAVVFLVAFWLLQQVS
HHHHHCCCCCCCCCCCCCCCCCCCCEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASVFGRTLLAVRDNEERAGAIGYDLKLLKLQAFVISGAVTGLAGALHAMMTGIAPLASAE
HHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YHTSEMILVMTVIGGTGTLLASLLGSAFYLIVGDWLSTLWPRWLLLLGVVLMVVSLGMQR
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLWGLLESAWERLRGAKGPSDGAPAGTGDKA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TILRKHFHLLLALAFVLAMPLTMQSGSLASEVLIYGLAAMGCNLLLGHTGLLSFGQGIF
CHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHH
FGLGSYTIALTLTRWPLPMPVALALAVVAGAVGAALVGWVAIRQRGTYFVMLTLAFAQMF
HCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHH
YFLAYSMPSLTGGDNGLMDIPRPSLAVGGFTLWPLASPWQYYGFVAVVFLVAFWLLQQVS
HHHHHCCCCCCCCCCCCCCCCCCCCEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASVFGRTLLAVRDNEERAGAIGYDLKLLKLQAFVISGAVTGLAGALHAMMTGIAPLASAE
HHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YHTSEMILVMTVIGGTGTLLASLLGSAFYLIVGDWLSTLWPRWLLLLGVVLMVVSLGMQR
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLWGLLESAWERLRGAKGPSDGAPAGTGDKA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]