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The map label for this gene is moaC [H]

Identifier: 120613308

GI number: 120613308

Start: 5221027

End: 5221515

Strand: Direct

Name: moaC [H]

Synonym: Aave_4677

Alternate gene names: 120613308

Gene position: 5221027-5221515 (Clockwise)

Preceding gene: 120613306

Following gene: 120613316

Centisome position: 97.54

GC content: 64.42

Gene sequence:

>489_bases
ATGACCAACCGTTCGCCCCACCTCACCCATTTCGACGCTGGCGGCCAGGCCCACATGGTGGACGTGGGCGACAAGCCCAA
TACCCGGCGCATCGCCGTCGCAAGCGGGCACATCGCCATGCAACCCGCCACCCTGGCGCTCATCGCCTCGGGCACGGCCG
GCAAGGGCGACGTACTGGGCATTGCCCGCATCGCGGGCATCCAGGCCGCGAAAAAGACCAGCGACCTGATTCCCCTGTGC
CACCCGCTGGCGCTGACGCGCGTGGCGGTGGATTTTCAGCTCGATGCCGATGCCTCATGCGTGCGCTGCACCGCGACCGT
GGAAACTGTCGGGCCTACCGGGGTGGAAATGGAAGCACTGACGGCGGTGCAGGTGGCGTTGCTCACCATCTACGACATGT
GCAAGGCTGTGGATCGGGGGATGGTGATGGAGGAGGTGCGGGTTGTGGAGAAGCACGGGGGGAAAAGTGGAAGCTTCTTG
AATAACTAA

Upstream 100 bases:

>100_bases
CCCCCTGGCGGGGCCTCTTGGATGCACGCATGGACCGTATGATGCCCCGGCGCGCCGATGGTGCCACTCCGTTACCTATT
CCCGCAAAGGGCCTCTTCCG

Downstream 100 bases:

>100_bases
TCTTGCGGAATTTTTTGCTACAGAGTTTTTAAAATTTAAAAGCAATTTAATTATTCAGTGACGATTCCTTTTATCAATTA
ATCCCCCTTCCCTCCATTTG

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTNRSPHLTHFDAGGQAHMVDVGDKPNTRRIAVASGHIAMQPATLALIASGTAGKGDVLGIARIAGIQAAKKTSDLIPLC
HPLALTRVAVDFQLDADASCVRCTATVETVGPTGVEMEALTAVQVALLTIYDMCKAVDRGMVMEEVRVVEKHGGKSGSFL
NN

Sequences:

>Translated_162_residues
MTNRSPHLTHFDAGGQAHMVDVGDKPNTRRIAVASGHIAMQPATLALIASGTAGKGDVLGIARIAGIQAAKKTSDLIPLC
HPLALTRVAVDFQLDADASCVRCTATVETVGPTGVEMEALTAVQVALLTIYDMCKAVDRGMVMEEVRVVEKHGGKSGSFL
NN
>Mature_161_residues
TNRSPHLTHFDAGGQAHMVDVGDKPNTRRIAVASGHIAMQPATLALIASGTAGKGDVLGIARIAGIQAAKKTSDLIPLCH
PLALTRVAVDFQLDADASCVRCTATVETVGPTGVEMEALTAVQVALLTIYDMCKAVDRGMVMEEVRVVEKHGGKSGSFLN
N

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family [H]

Homologues:

Organism=Escherichia coli, GI1787001, Length=153, Percent_Identity=56.2091503267974, Blast_Score=164, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566331, Length=155, Percent_Identity=45.8064516129032, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574490, Length=149, Percent_Identity=51.6778523489933, Blast_Score=142, Evalue=8e-35,
Organism=Drosophila melanogaster, GI28574492, Length=137, Percent_Identity=51.8248175182482, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC [H]

EC number: NA

Molecular weight: Translated: 16934; Mature: 16803

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRSPHLTHFDAGGQAHMVDVGDKPNTRRIAVASGHIAMQPATLALIASGTAGKGDVLG
CCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEECCCEEECCEEEEEEECCCCCCCCEEE
IARIAGIQAAKKTSDLIPLCHPLALTRVAVDFQLDADASCVRCTATVETVGPTGVEMEAL
HHHHHHHHHHHHCCCCCCHHHHHHHEEEEEEEEECCCCCEEEEEEEEEECCCCCCCHHHH
TAVQVALLTIYDMCKAVDRGMVMEEVRVVEKHGGKSGSFLNN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TNRSPHLTHFDAGGQAHMVDVGDKPNTRRIAVASGHIAMQPATLALIASGTAGKGDVLG
CCCCCCEEEECCCCEEEEEECCCCCCCCEEEEECCCEEECCEEEEEEECCCCCCCCEEE
IARIAGIQAAKKTSDLIPLCHPLALTRVAVDFQLDADASCVRCTATVETVGPTGVEMEAL
HHHHHHHHHHHHCCCCCCHHHHHHHEEEEEEEEECCCCCEEEEEEEEEECCCCCCCHHHH
TAVQVALLTIYDMCKAVDRGMVMEEVRVVEKHGGKSGSFLNN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA