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The map label for this gene is tktA [H]

Identifier: 120613218

GI number: 120613218

Start: 5103342

End: 5105429

Strand: Direct

Name: tktA [H]

Synonym: Aave_4585

Alternate gene names: 120613218

Gene position: 5103342-5105429 (Clockwise)

Preceding gene: 120613213

Following gene: 120613219

Centisome position: 95.34

GC content: 69.3

Gene sequence:

>2088_bases
ATGGCCAATTCTCAACAGATGGCGAATGCGATCCGCGCACTCGCAATGGATGCAGTTCAACAGGCCAATTCCGGCCATCC
CGGTGCCCCGATGGGCATGGCCGACATGGCCGTCGCGCTGTGGTCCCGCCACCTCCGCCACAACCCCGCCAATCCGCAGT
GGGCCGACCGCGACCGCTTCGTGCTCTCCAACGGCCACGGCTCCATGCTGCTGTACGCGCTGCTGCACCTCACGGGCTAC
GACCTGCCCATCGAGGAGCTGAAGAACTTCCGCCAGCTGCACAGCAAGACGGCCGGCCACCCCGAATACGGCATCACCCC
CGGCGTCGAGACGACCACCGGCCCGCTGGGCCAGGGCATCACCAACGCCGTGGGCTTCGCGCTGGCCGAGAAGCTGCTGG
CCCGCGAGTTCAACCGCAGGAACGGCGACGTGGACCACACCATCGTGGACCACCACACCTACGTGTTCCTCGGCGACGGC
TGCCTGATGGAGGGCATCAGCCAGGAGGCGATCTCGCTGGCCGGCGCCTGGAAGCTGGGCAAGCTGATCGCGCTCTACGA
CGACAACGGCATCTCCATCGACGGCCAGGTCGCGCCCTGGTTCGTGGACGACACGCCGGGCCGCTTCCGCGCCAGCGGCT
GGAACGTGATCGGACCGGTCGATGGCCACGACGTGGAGGCCGTGGCCGCCGCGGTGCAGAGCGCCAAGACCAGCATCGAC
AAGCCCACCCTGATCGTCTGCAAGACCGCCATCGGCAAGGGTTCGCCCAACCGCGCCGGCACCTCCAAGGCCCACGGCGA
GCCGCTGGGCGCCGACGAGATCACCCTGACGCGCAACGCCATCGGCTGGAGCCACGTGCCCTTCGAGATCCCGGCCGAGG
TCTATGCGGACTGGAACGCCAAGGACGCCGGCGCGCAGGCCGAGGCCGACTGGCAGCAGCGCTTCGACGCCTACGCCGCC
GCGTATCCCGAACTGGCCGCCGAATTCCTGCGCCGCATGGCGGGCGACCTGCCCAGGCACTTCGCCCAGACCGCCGTGGA
CACCGTGGTGAACGCCCACACCAAGGCCGAGACCGTGGCCAGCCGCAAGGCCAGCCAGCTCGCGCTGGAAGCCTTCACGG
CCGCGCTGCCCGAACTGCTCGGCGGCAGCGCCGACCTGACGGGCTCCAACCTCACCAACACCAAGAGCACGCCCGCGCTG
CGCTTCGACGAGCAGGGCGACGTGGTGCAGGTGGAAGTCAACACCGGCGGCGCGGAAACCGCCAAGCTGGGCGGCCGCCA
CATCAACTACGGCGTGCGCGAGTTCGGCATGGCCGCGATCATGAACGGCATCGCGCTGCACGGCGGCTTCATCCCCTACG
GCGGCACCTTCCTCACGTTCAGCGACTACAGCCGCAACGCCATCCGCATGGCCGCGCTCATGAAGCTGCGCGTGGTGCAC
GTGTTCACGCACGACTCCATCGGCCTGGGCGAAGACGGCCCCACCCACCAGTCGATCGAGCATGCCGCCAGCCTGCGACT
GATCCCGGGCCTGGACGTCTGGCGCCCCGCCGACACGGCCGAGACCGCCGTGGCCTGGAGCGTGGCCCTGTCCAACCGCA
ACCGGCCCACCGCCCTGCTGCTGTCGCGCCAGAACCTGGCCTACGCGGCCAAGCGCGACCTGGGCGACATCTCGCGCGGC
GCCTACGTGCTCTCCGAGCCGGCCGACGCGGGCATCAAGAAAAAGGCCCAGGCCGTGATCATCGCCACGGGCTCCGAAGT
CCAGCTGGCCCTGGCCGCGCAGAAGCTGCTGGCCGAGAAGAAGATCGCCGTGCGCGTGGTCTCCATGCCCAGCACCACCA
CCTTCGACCGCGAGGATGCGAAGTACAAGGCCAGCGTGCTGCCGGCCGGCGTGCCGCGCATCGCCGTGGAGATGGGCGTG
ACCGACTTCTGGTGGAAGTACGGCTGCGCCGCCGTGGTCGGCATCGATACCTTCGGCGAATCGGCCCCGGCCCCGGTGCT
GTTCAAGCACTTCGGCTTCACGCCGGAGAACGTGGCCGACTCCGTGATGGTGGCGATCGGCGCCGCGCGGCTGAAGAAGG
CCCGCTGA

Upstream 100 bases:

>100_bases
CACTGTAGTGCAGGGCACGGCCATTCCATGGGCAAAGCAAGGGGTGGCCCGGTAAAATGCGCGGTTTTCCCCTCCCCAGC
CCCTTCCGGAGCCGCCCCTG

Downstream 100 bases:

>100_bases
CACCGCGGCACGGCACCTCAGTCGATCCAGCGATGGCAACCAGCAGCAAAGTGAGCAAGGCTCTGGTATTCGTGGCGACG
GGGGCGGTGGGTGCCGTGGT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MANSQQMANAIRALAMDAVQQANSGHPGAPMGMADMAVALWSRHLRHNPANPQWADRDRFVLSNGHGSMLLYALLHLTGY
DLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGFALAEKLLAREFNRRNGDVDHTIVDHHTYVFLGDG
CLMEGISQEAISLAGAWKLGKLIALYDDNGISIDGQVAPWFVDDTPGRFRASGWNVIGPVDGHDVEAVAAAVQSAKTSID
KPTLIVCKTAIGKGSPNRAGTSKAHGEPLGADEITLTRNAIGWSHVPFEIPAEVYADWNAKDAGAQAEADWQQRFDAYAA
AYPELAAEFLRRMAGDLPRHFAQTAVDTVVNAHTKAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPAL
RFDEQGDVVQVEVNTGGAETAKLGGRHINYGVREFGMAAIMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKLRVVH
VFTHDSIGLGEDGPTHQSIEHAASLRLIPGLDVWRPADTAETAVAWSVALSNRNRPTALLLSRQNLAYAAKRDLGDISRG
AYVLSEPADAGIKKKAQAVIIATGSEVQLALAAQKLLAEKKIAVRVVSMPSTTTFDREDAKYKASVLPAGVPRIAVEMGV
TDFWWKYGCAAVVGIDTFGESAPAPVLFKHFGFTPENVADSVMVAIGAARLKKAR

Sequences:

>Translated_695_residues
MANSQQMANAIRALAMDAVQQANSGHPGAPMGMADMAVALWSRHLRHNPANPQWADRDRFVLSNGHGSMLLYALLHLTGY
DLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGFALAEKLLAREFNRRNGDVDHTIVDHHTYVFLGDG
CLMEGISQEAISLAGAWKLGKLIALYDDNGISIDGQVAPWFVDDTPGRFRASGWNVIGPVDGHDVEAVAAAVQSAKTSID
KPTLIVCKTAIGKGSPNRAGTSKAHGEPLGADEITLTRNAIGWSHVPFEIPAEVYADWNAKDAGAQAEADWQQRFDAYAA
AYPELAAEFLRRMAGDLPRHFAQTAVDTVVNAHTKAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPAL
RFDEQGDVVQVEVNTGGAETAKLGGRHINYGVREFGMAAIMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKLRVVH
VFTHDSIGLGEDGPTHQSIEHAASLRLIPGLDVWRPADTAETAVAWSVALSNRNRPTALLLSRQNLAYAAKRDLGDISRG
AYVLSEPADAGIKKKAQAVIIATGSEVQLALAAQKLLAEKKIAVRVVSMPSTTTFDREDAKYKASVLPAGVPRIAVEMGV
TDFWWKYGCAAVVGIDTFGESAPAPVLFKHFGFTPENVADSVMVAIGAARLKKAR
>Mature_694_residues
ANSQQMANAIRALAMDAVQQANSGHPGAPMGMADMAVALWSRHLRHNPANPQWADRDRFVLSNGHGSMLLYALLHLTGYD
LPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGFALAEKLLAREFNRRNGDVDHTIVDHHTYVFLGDGC
LMEGISQEAISLAGAWKLGKLIALYDDNGISIDGQVAPWFVDDTPGRFRASGWNVIGPVDGHDVEAVAAAVQSAKTSIDK
PTLIVCKTAIGKGSPNRAGTSKAHGEPLGADEITLTRNAIGWSHVPFEIPAEVYADWNAKDAGAQAEADWQQRFDAYAAA
YPELAAEFLRRMAGDLPRHFAQTAVDTVVNAHTKAETVASRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPALR
FDEQGDVVQVEVNTGGAETAKLGGRHINYGVREFGMAAIMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKLRVVHV
FTHDSIGLGEDGPTHQSIEHAASLRLIPGLDVWRPADTAETAVAWSVALSNRNRPTALLLSRQNLAYAAKRDLGDISRGA
YVLSEPADAGIKKKAQAVIIATGSEVQLALAAQKLLAEKKIAVRVVSMPSTTTFDREDAKYKASVLPAGVPRIAVEMGVT
DFWWKYGCAAVVGIDTFGESAPAPVLFKHFGFTPENVADSVMVAIGAARLKKAR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=266, Percent_Identity=32.7067669172932, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI205277463, Length=271, Percent_Identity=33.5793357933579, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI4507521, Length=271, Percent_Identity=33.5793357933579, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI225637459, Length=266, Percent_Identity=25.9398496240602, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI225637461, Length=162, Percent_Identity=30.8641975308642, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI225637463, Length=162, Percent_Identity=30.8641975308642, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994911, Length=683, Percent_Identity=58.8579795021962, Blast_Score=816, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=688, Percent_Identity=56.25, Blast_Score=777, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=533, Percent_Identity=26.6416510318949, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=683, Percent_Identity=48.0234260614934, Blast_Score=584, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319593, Length=696, Percent_Identity=43.1034482758621, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45551847, Length=270, Percent_Identity=34.0740740740741, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45550715, Length=270, Percent_Identity=34.0740740740741, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24666278, Length=270, Percent_Identity=32.2222222222222, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24645119, Length=235, Percent_Identity=35.3191489361702, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74291; Mature: 74160

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSQQMANAIRALAMDAVQQANSGHPGAPMGMADMAVALWSRHLRHNPANPQWADRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLLYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGFALAEKLLAREFNRRNGDVDHTIVDHHTYVFLGDGCLMEGISQEAISLAGAWKLG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEEEEECCCHHHHCCHHHHHHHHCCCCCC
KLIALYDDNGISIDGQVAPWFVDDTPGRFRASGWNVIGPVDGHDVEAVAAAVQSAKTSID
CEEEEECCCCEEECCEECCEEECCCCCCEECCCCCEECCCCCCHHHHHHHHHHHHHHCCC
KPTLIVCKTAIGKGSPNRAGTSKAHGEPLGADEITLTRNAIGWSHVPFEIPAEVYADWNA
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCC
KDAGAQAEADWQQRFDAYAAAYPELAAEFLRRMAGDLPRHFAQTAVDTVVNAHTKAETVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPALRFDEQGDVVQVEVNTGGAET
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCH
AKLGGRHINYGVREFGMAAIMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKLRVVH
HHCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHEEE
VFTHDSIGLGEDGPTHQSIEHAASLRLIPGLDVWRPADTAETAVAWSVALSNRNRPTALL
EEECCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCHHHHEEEEEEECCCCCCEEEE
LSRQNLAYAAKRDLGDISRGAYVLSEPADAGIKKKAQAVIIATGSEVQLALAAQKLLAEK
EECCCHHHHHHHCCCHHCCCCEEEECCCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHC
KIAVRVVSMPSTTTFDREDAKYKASVLPAGVPRIAVEMGVTDFWWKYGCAAVVGIDTFGE
CEEEEEEECCCCCCCCCCCCCEEHHCCCCCCCCEEEECCCHHHHHHHCCEEEEEEHHCCC
SAPAPVLFKHFGFTPENVADSVMVAIGAARLKKAR
CCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANSQQMANAIRALAMDAVQQANSGHPGAPMGMADMAVALWSRHLRHNPANPQWADRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLLYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGFALAEKLLAREFNRRNGDVDHTIVDHHTYVFLGDGCLMEGISQEAISLAGAWKLG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEEEEECCCHHHHCCHHHHHHHHCCCCCC
KLIALYDDNGISIDGQVAPWFVDDTPGRFRASGWNVIGPVDGHDVEAVAAAVQSAKTSID
CEEEEECCCCEEECCEECCEEECCCCCCEECCCCCEECCCCCCHHHHHHHHHHHHHHCCC
KPTLIVCKTAIGKGSPNRAGTSKAHGEPLGADEITLTRNAIGWSHVPFEIPAEVYADWNA
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCC
KDAGAQAEADWQQRFDAYAAAYPELAAEFLRRMAGDLPRHFAQTAVDTVVNAHTKAETVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKASQLALEAFTAALPELLGGSADLTGSNLTNTKSTPALRFDEQGDVVQVEVNTGGAET
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCH
AKLGGRHINYGVREFGMAAIMNGIALHGGFIPYGGTFLTFSDYSRNAIRMAALMKLRVVH
HHCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHEEE
VFTHDSIGLGEDGPTHQSIEHAASLRLIPGLDVWRPADTAETAVAWSVALSNRNRPTALL
EEECCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCHHHHEEEEEEECCCCCCEEEE
LSRQNLAYAAKRDLGDISRGAYVLSEPADAGIKKKAQAVIIATGSEVQLALAAQKLLAEK
EECCCHHHHHHHCCCHHCCCCEEEECCCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHC
KIAVRVVSMPSTTTFDREDAKYKASVLPAGVPRIAVEMGVTDFWWKYGCAAVVGIDTFGE
CEEEEEEECCCCCCCCCCCCCEEHHCCCCCCCCEEEECCCHHHHHHHCCEEEEEEHHCCC
SAPAPVLFKHFGFTPENVADSVMVAIGAARLKKAR
CCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]