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The map label for this gene is hipA [H]

Identifier: 120613153

GI number: 120613153

Start: 5020136

End: 5021458

Strand: Direct

Name: hipA [H]

Synonym: Aave_4520

Alternate gene names: 120613153

Gene position: 5020136-5021458 (Clockwise)

Preceding gene: 120613152

Following gene: 120613155

Centisome position: 93.79

GC content: 64.02

Gene sequence:

>1323_bases
ATGGTGGCGCTCGACGCGTGGATGAATGGCGAATTCGTCGGCACCTGGCAGGTCCACAGAGGAGCCCACAGCTTCTCGTA
CGCCCCCTCATGGCTGGAGTCCGAAAAATCCCGGCCCCTGTCTTTGTCGCTACCCCTCACCCGCACCCTGGAGATCAAGG
GAGAGGTCGTCGCGAACTACTTCGACAACCTCCTGCCTGACAACGAACGGATCCGAGAGCGCATCGCCCGGCGATTCAAG
ACCAGGGCACGCGATACGTTCACCTTGCTGGAGGCCATCGGCCGTGACTGCGTTGGTGCCGTGCAGCTGCTTCCGGAAGG
AACGACCCCGGACGGGTGGAACCGTGTGGCAGGCGAGCCGCTGACCGACGAACAGGTCGCGGCAGCGCTCCGTGCAGTGC
CCGATGACCCGGTCGCGCGGCATGCCAATGAAGCTCGGCCCTTCCGTATTTCCCTGGCCGGAGCCCAGGAAAAAACCGCC
TTCGTGCAGGTCAACGGCCAGTGGTGCAGTCCCGTCGGCGCCACCCCGAGCACCCACATCTTCAAGCTCCCGCTCGGCGT
GATCGCCAACACCACCCAGGTGGACATGTTCGACTCTGTCGAAAACGAATGGCTGTGCGCGCAGATCGTCCAGGCGCTCG
GCCTGCCCATGGCGCGCACCGAAATGGCCACGTTCGGCGACCAGAAAGCCCTGATCGTGGAGCGCTTCGACCGCGAATGG
ATGGACGGCGGCAAGTGGATCGCCCGGCTTCCCCAGGAAGACTTCTGCCAGGCGCTGGGCCTGCCCTCACATTTGAAGTA
CGAAAGCGATGGCGGGCCGTCCGTCGCGACTGGCCTCACGCTGCTGGCCGGAAGCGCTGATGCGGACATGGACCGCATGG
CTTTCCAGTTGGCCCAACTGGCCTTTTGGCTCATGGCAGCGCCCGACGGCCATGCGAAGAACTTTTCGATTTTCCTGCGC
CAGGGCAATGCCTACGACATGGCGCCCCTGTACGACGTACTTTCCGTCTGGCCCTACGTGGGCAGGAAAAGGGGGCAACT
GCATTTGCGCGATGTGCGCCTCGCCATGGCGCTGCGCTCGAAAAACACGCACTACGAGATACACACCATCCGGGCCCGGC
ACTGGCATGCCCTCGCCATGAAAAACGGCGGCCCTCCGATCTGGAAGGCGATGCAGGACCTGGTCGGTGGCGTCGGTCAG
GCCCTCGAGTCCGTGGAAGCGCAACTGCCCCGGAGCTTTCCCGAGCGCATCTGGGACCCGATCGCGAAAGGCATGCGGGG
CCAGGCAGAAAAATTTCTCTCGGAAGCCGCCAGCCTCCCTTGA

Upstream 100 bases:

>100_bases
CGTCGGACGCGCAAGCGCTGCGAGACGCCAACCCGAACACCGATGTCACACCGACATCCGGGCGCAACTTTGTCATACGG
CCCAAGAAGGGCTCTTGGTA

Downstream 100 bases:

>100_bases
TCACAGGCGCATGGCTCGCTCACGATCTCCCGAGACCGAGCCAAGCCGCACCCACCAAGCAAAAAGCCCCCGGCTTTGCT
GTCCATGCATTTCCGCGCCA

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MVALDAWMNGEFVGTWQVHRGAHSFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANYFDNLLPDNERIRERIARRFK
TRARDTFTLLEAIGRDCVGAVQLLPEGTTPDGWNRVAGEPLTDEQVAAALRAVPDDPVARHANEARPFRISLAGAQEKTA
FVQVNGQWCSPVGATPSTHIFKLPLGVIANTTQVDMFDSVENEWLCAQIVQALGLPMARTEMATFGDQKALIVERFDREW
MDGGKWIARLPQEDFCQALGLPSHLKYESDGGPSVATGLTLLAGSADADMDRMAFQLAQLAFWLMAAPDGHAKNFSIFLR
QGNAYDMAPLYDVLSVWPYVGRKRGQLHLRDVRLAMALRSKNTHYEIHTIRARHWHALAMKNGGPPIWKAMQDLVGGVGQ
ALESVEAQLPRSFPERIWDPIAKGMRGQAEKFLSEAASLP

Sequences:

>Translated_440_residues
MVALDAWMNGEFVGTWQVHRGAHSFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANYFDNLLPDNERIRERIARRFK
TRARDTFTLLEAIGRDCVGAVQLLPEGTTPDGWNRVAGEPLTDEQVAAALRAVPDDPVARHANEARPFRISLAGAQEKTA
FVQVNGQWCSPVGATPSTHIFKLPLGVIANTTQVDMFDSVENEWLCAQIVQALGLPMARTEMATFGDQKALIVERFDREW
MDGGKWIARLPQEDFCQALGLPSHLKYESDGGPSVATGLTLLAGSADADMDRMAFQLAQLAFWLMAAPDGHAKNFSIFLR
QGNAYDMAPLYDVLSVWPYVGRKRGQLHLRDVRLAMALRSKNTHYEIHTIRARHWHALAMKNGGPPIWKAMQDLVGGVGQ
ALESVEAQLPRSFPERIWDPIAKGMRGQAEKFLSEAASLP
>Mature_440_residues
MVALDAWMNGEFVGTWQVHRGAHSFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANYFDNLLPDNERIRERIARRFK
TRARDTFTLLEAIGRDCVGAVQLLPEGTTPDGWNRVAGEPLTDEQVAAALRAVPDDPVARHANEARPFRISLAGAQEKTA
FVQVNGQWCSPVGATPSTHIFKLPLGVIANTTQVDMFDSVENEWLCAQIVQALGLPMARTEMATFGDQKALIVERFDREW
MDGGKWIARLPQEDFCQALGLPSHLKYESDGGPSVATGLTLLAGSADADMDRMAFQLAQLAFWLMAAPDGHAKNFSIFLR
QGNAYDMAPLYDVLSVWPYVGRKRGQLHLRDVRLAMALRSKNTHYEIHTIRARHWHALAMKNGGPPIWKAMQDLVGGVGQ
ALESVEAQLPRSFPERIWDPIAKGMRGQAEKFLSEAASLP

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=422, Percent_Identity=43.6018957345972, Blast_Score=333, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 48881; Mature: 48881

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALDAWMNGEFVGTWQVHRGAHSFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANY
CEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHHCCCCCEEEECCCEEEEEECHHHHHHH
FDNLLPDNERIRERIARRFKTRARDTFTLLEAIGRDCVGAVQLLPEGTTPDGWNRVAGEP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCC
LTDEQVAAALRAVPDDPVARHANEARPFRISLAGAQEKTAFVQVNGQWCSPVGATPSTHI
CCHHHHHHHHHCCCCCHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCEE
FKLPLGVIANTTQVDMFDSVENEWLCAQIVQALGLPMARTEMATFGDQKALIVERFDREW
EEECHHHHCCCCEEHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
MDGGKWIARLPQEDFCQALGLPSHLKYESDGGPSVATGLTLLAGSADADMDRMAFQLAQL
HCCCHHHHHCCHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHH
AFWLMAAPDGHAKNFSIFLRQGNAYDMAPLYDVLSVWPYVGRKRGQLHLRDVRLAMALRS
HHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
KNTHYEIHTIRARHWHALAMKNGGPPIWKAMQDLVGGVGQALESVEAQLPRSFPERIWDP
CCCEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IAKGMRGQAEKFLSEAASLP
HHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MVALDAWMNGEFVGTWQVHRGAHSFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANY
CEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHHCCCCCEEEECCCEEEEEECHHHHHHH
FDNLLPDNERIRERIARRFKTRARDTFTLLEAIGRDCVGAVQLLPEGTTPDGWNRVAGEP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCC
LTDEQVAAALRAVPDDPVARHANEARPFRISLAGAQEKTAFVQVNGQWCSPVGATPSTHI
CCHHHHHHHHHCCCCCHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCEE
FKLPLGVIANTTQVDMFDSVENEWLCAQIVQALGLPMARTEMATFGDQKALIVERFDREW
EEECHHHHCCCCEEHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
MDGGKWIARLPQEDFCQALGLPSHLKYESDGGPSVATGLTLLAGSADADMDRMAFQLAQL
HCCCHHHHHCCHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHH
AFWLMAAPDGHAKNFSIFLRQGNAYDMAPLYDVLSVWPYVGRKRGQLHLRDVRLAMALRS
HHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
KNTHYEIHTIRARHWHALAMKNGGPPIWKAMQDLVGGVGQALESVEAQLPRSFPERIWDP
CCCEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IAKGMRGQAEKFLSEAASLP
HHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]