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The map label for this gene is atsA [H]

Identifier: 120613101

GI number: 120613101

Start: 4962817

End: 4964178

Strand: Reverse

Name: atsA [H]

Synonym: Aave_4466

Alternate gene names: 120613101

Gene position: 4964178-4962817 (Counterclockwise)

Preceding gene: 120613102

Following gene: 120613100

Centisome position: 92.74

GC content: 70.34

Gene sequence:

>1362_bases
GTGAATACTCCCACGGGCCGCGCCGCACCGCGGCCCAATATCGTCTTCATCGTCGCCGACGATCTGGGCTACGCCGACCT
GGGGTGCTACGGCGGGCGCGATGCCGCCTTCGGCCCCGTCTCGCCCGTGCTGGACCGTCTGGCCGCCGGCGGATTGAAGC
TCACCCAGGGCTACTCCAACTCGCCCGTCTGCTCGCCCACGCGCTTCGCGCTCATGACGGCGCGCTACCAATACCGCCTG
CGCGGCGCGGCCGAGGAACCGATCCGCACCGCCACCCGCGGCAACGACCGCCTGGGCCTGCCGCCCGCCCACCCCACGCT
GCCCTCGCTGCTCAAGGACGCCGGCTACCGCACCGCCCTCATGGGCAAATGGCACCTGGGCTACCCGCCGCATTTCAGCC
CCTTGACGTCGGGCTACGAAGAATTCTTCGGCCCCATGTCCGGCGGGGTGGACTACTTCACCCACTGCGGCGCCAACGGC
ACGCACGACCTCTGGTTCGGCGAAGAGGAAAAGGCCCAGGAGGGCTACCTGACCGACCTCATCACCGACCACTCGGTGGA
CTACATCGCGCGCATGGCCGGCGGCGCAAAAGAGCAGGGCACGCCGTTCTTCCTGAGCGTGCACTACACCGCCCCGCACT
GGCCCTGGGAAACCCGCGACGACGAGGCCCTGGCCCACGAGTTGCGCGACAGCAAGCAGCCCATCTACCACCTGGCCGGC
GGCAACGTGGAAACCTACCGCCGCATGATCCACCACATGGACGAGGGCATCGGCCGCATCATGGACACGCTGCGCGCCCA
CGGCCTGGAGCGCGACACCCTCGTCGTCTTCACCAGCGACAACGGCGGCGAGCGCTTCTCCGACAACTGGCCCCTGGTGG
GCGGCAAGATGGACCTGACCGAGGGCGGCATCCGCGTGCCCTGGATCGCCCACTGGCCCGCCGCCATCGCCCCCGGCGGC
ACCAGTGCCCAGCCCTGCCTGACCATGGACTGGAGCGCCACCATGCTGGAGCTGGGCGGCGCGCAGCCGCATCCGGACTA
CCCGTGGGACGGCCAGACCCTGGCCCCGCTGCTGCACGCCGCGGCCTGGACCGCCGACCGCCCCCTGTTCTGGCGCATGA
ACCACCGCGGCCAGCGCGCCATGCGGCACGGCGACTGGAAATACCTGCGGGTGGATGGCGTGGATTACCTGTTCAACCTC
GCCCAGGACGAGCGCGAGCGGGCCAACCTGGCGCCGCTGCAGCCTGGGCGGCTGGCGGAGATGGTGCAGGCCTGGGAAGC
GTGGGAGGCGACCATGCCGGCGATTCCGGGGGATGCGACCGTGAGCCTCTGCTACACGGACAAGGACATGCCGGCGCGGT
AG

Upstream 100 bases:

>100_bases
CCAGCACCCCCGCGCAGACGCGCCAGAGCATCGCCGCCTACCGCAAGCAGTGGGAGCCCGTGATCCGCAACTCGGGATAC
CGCCCGTGAGCGCCGCACCG

Downstream 100 bases:

>100_bases
GCCCACTTTGCCGGGCCGCCGGGGTTAGACTGTACAGAATTCTGCTGACTCCCTAGCCGAGGTGCACCATGGGTTTTTCC
GCAAGCGATGTCGTACCGTT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MNTPTGRAAPRPNIVFIVADDLGYADLGCYGGRDAAFGPVSPVLDRLAAGGLKLTQGYSNSPVCSPTRFALMTARYQYRL
RGAAEEPIRTATRGNDRLGLPPAHPTLPSLLKDAGYRTALMGKWHLGYPPHFSPLTSGYEEFFGPMSGGVDYFTHCGANG
THDLWFGEEEKAQEGYLTDLITDHSVDYIARMAGGAKEQGTPFFLSVHYTAPHWPWETRDDEALAHELRDSKQPIYHLAG
GNVETYRRMIHHMDEGIGRIMDTLRAHGLERDTLVVFTSDNGGERFSDNWPLVGGKMDLTEGGIRVPWIAHWPAAIAPGG
TSAQPCLTMDWSATMLELGGAQPHPDYPWDGQTLAPLLHAAAWTADRPLFWRMNHRGQRAMRHGDWKYLRVDGVDYLFNL
AQDERERANLAPLQPGRLAEMVQAWEAWEATMPAIPGDATVSLCYTDKDMPAR

Sequences:

>Translated_453_residues
MNTPTGRAAPRPNIVFIVADDLGYADLGCYGGRDAAFGPVSPVLDRLAAGGLKLTQGYSNSPVCSPTRFALMTARYQYRL
RGAAEEPIRTATRGNDRLGLPPAHPTLPSLLKDAGYRTALMGKWHLGYPPHFSPLTSGYEEFFGPMSGGVDYFTHCGANG
THDLWFGEEEKAQEGYLTDLITDHSVDYIARMAGGAKEQGTPFFLSVHYTAPHWPWETRDDEALAHELRDSKQPIYHLAG
GNVETYRRMIHHMDEGIGRIMDTLRAHGLERDTLVVFTSDNGGERFSDNWPLVGGKMDLTEGGIRVPWIAHWPAAIAPGG
TSAQPCLTMDWSATMLELGGAQPHPDYPWDGQTLAPLLHAAAWTADRPLFWRMNHRGQRAMRHGDWKYLRVDGVDYLFNL
AQDERERANLAPLQPGRLAEMVQAWEAWEATMPAIPGDATVSLCYTDKDMPAR
>Mature_453_residues
MNTPTGRAAPRPNIVFIVADDLGYADLGCYGGRDAAFGPVSPVLDRLAAGGLKLTQGYSNSPVCSPTRFALMTARYQYRL
RGAAEEPIRTATRGNDRLGLPPAHPTLPSLLKDAGYRTALMGKWHLGYPPHFSPLTSGYEEFFGPMSGGVDYFTHCGANG
THDLWFGEEEKAQEGYLTDLITDHSVDYIARMAGGAKEQGTPFFLSVHYTAPHWPWETRDDEALAHELRDSKQPIYHLAG
GNVETYRRMIHHMDEGIGRIMDTLRAHGLERDTLVVFTSDNGGERFSDNWPLVGGKMDLTEGGIRVPWIAHWPAAIAPGG
TSAQPCLTMDWSATMLELGGAQPHPDYPWDGQTLAPLLHAAAWTADRPLFWRMNHRGQRAMRHGDWKYLRVDGVDYLFNL
AQDERERANLAPLQPGRLAEMVQAWEAWEATMPAIPGDATVSLCYTDKDMPAR

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=390, Percent_Identity=32.5641025641026, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI109389362, Length=353, Percent_Identity=30.028328611898, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI53831991, Length=536, Percent_Identity=28.544776119403, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI59797060, Length=484, Percent_Identity=29.7520661157025, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI38569407, Length=364, Percent_Identity=32.1428571428571, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI38569405, Length=432, Percent_Identity=30.3240740740741, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI146229331, Length=402, Percent_Identity=32.3383084577114, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI146229329, Length=402, Percent_Identity=32.3383084577114, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI6005990, Length=402, Percent_Identity=32.3383084577114, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI146229324, Length=402, Percent_Identity=32.3383084577114, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI58743319, Length=427, Percent_Identity=30.2107728337237, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI157266309, Length=143, Percent_Identity=39.1608391608392, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI45430057, Length=394, Percent_Identity=27.4111675126904, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71852586, Length=147, Percent_Identity=36.734693877551, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI71852584, Length=150, Percent_Identity=36.6666666666667, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI31742482, Length=153, Percent_Identity=39.8692810457516, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI189571643, Length=479, Percent_Identity=22.964509394572, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI189571641, Length=479, Percent_Identity=22.964509394572, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI189571638, Length=479, Percent_Identity=22.964509394572, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI189571636, Length=479, Percent_Identity=22.964509394572, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI146229327, Length=319, Percent_Identity=28.8401253918495, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI87081924, Length=404, Percent_Identity=28.2178217821782, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790233, Length=436, Percent_Identity=26.8348623853211, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790112, Length=374, Percent_Identity=24.0641711229947, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115533416, Length=452, Percent_Identity=30.3097345132743, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115533418, Length=442, Percent_Identity=29.8642533936652, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17568795, Length=372, Percent_Identity=25.2688172043011, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17559078, Length=127, Percent_Identity=39.3700787401575, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281363223, Length=416, Percent_Identity=30.5288461538462, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24666109, Length=411, Percent_Identity=31.6301703163017, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281366397, Length=458, Percent_Identity=27.5109170305677, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281366395, Length=458, Percent_Identity=27.5109170305677, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666163, Length=458, Percent_Identity=27.5109170305677, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666175, Length=370, Percent_Identity=28.1081081081081, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24647401, Length=380, Percent_Identity=24.7368421052632, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922168, Length=376, Percent_Identity=24.7340425531915, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24653364, Length=376, Percent_Identity=24.7340425531915, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 50202; Mature: 50202

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPTGRAAPRPNIVFIVADDLGYADLGCYGGRDAAFGPVSPVLDRLAAGGLKLTQGYSN
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCC
SPVCSPTRFALMTARYQYRLRGAAEEPIRTATRGNDRLGLPPAHPTLPSLLKDAGYRTAL
CCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEE
MGKWHLGYPPHFSPLTSGYEEFFGPMSGGVDYFTHCGANGTHDLWFGEEEKAQEGYLTDL
EECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHH
ITDHSVDYIARMAGGAKEQGTPFFLSVHYTAPHWPWETRDDEALAHELRDSKQPIYHLAG
HHHCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECC
GNVETYRRMIHHMDEGIGRIMDTLRAHGLERDTLVVFTSDNGGERFSDNWPLVGGKMDLT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEECCEEECC
EGGIRVPWIAHWPAAIAPGGTSAQPCLTMDWSATMLELGGAQPHPDYPWDGQTLAPLLHA
CCCEECCEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCCCCCHHHHHHHH
AAWTADRPLFWRMNHRGQRAMRHGDWKYLRVDGVDYLFNLAQDERERANLAPLQPGRLAE
HHHCCCCCEEEEECCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHH
MVQAWEAWEATMPAIPGDATVSLCYTDKDMPAR
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MNTPTGRAAPRPNIVFIVADDLGYADLGCYGGRDAAFGPVSPVLDRLAAGGLKLTQGYSN
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCC
SPVCSPTRFALMTARYQYRLRGAAEEPIRTATRGNDRLGLPPAHPTLPSLLKDAGYRTAL
CCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEE
MGKWHLGYPPHFSPLTSGYEEFFGPMSGGVDYFTHCGANGTHDLWFGEEEKAQEGYLTDL
EECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHH
ITDHSVDYIARMAGGAKEQGTPFFLSVHYTAPHWPWETRDDEALAHELRDSKQPIYHLAG
HHHCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECC
GNVETYRRMIHHMDEGIGRIMDTLRAHGLERDTLVVFTSDNGGERFSDNWPLVGGKMDLT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEECCEEECC
EGGIRVPWIAHWPAAIAPGGTSAQPCLTMDWSATMLELGGAQPHPDYPWDGQTLAPLLHA
CCCEECCEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCCCCCHHHHHHHH
AAWTADRPLFWRMNHRGQRAMRHGDWKYLRVDGVDYLFNLAQDERERANLAPLQPGRLAE
HHHCCCCCEEEEECCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHH
MVQAWEAWEATMPAIPGDATVSLCYTDKDMPAR
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]