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The map label for this gene is ilvA [H]

Identifier: 120613077

GI number: 120613077

Start: 4935636

End: 4936655

Strand: Direct

Name: ilvA [H]

Synonym: Aave_4441

Alternate gene names: 120613077

Gene position: 4935636-4936655 (Clockwise)

Preceding gene: 120613076

Following gene: 120613079

Centisome position: 92.21

GC content: 74.51

Gene sequence:

>1020_bases
ATGAACGCCGCCCTGCCCGCCTCCGCGCCCGATGCATCCGCCCGGCCCCACGCCGCGCTGCCGAGCCTCGCCGACATCGA
GGCCGCGGCGGAGGTGGTCTATGCCGACTTCGCTCCCACGCCGCAGTACCGCTGGGCGCTGCTCGGCGAGCGCCTGGGCG
CCGAGTGCTGGATCAAGCACGAGAACCACACGCCCGTGGGCGCGTTCAAGATCCGCGGCGGCCTCACGTATTTCGACCAG
CTCGCGCGCCGCGGGGACATGCCGCGCGAGGTGATCAGCGCCACGCGCGGCAACCATGGCCAGAGCCTGGGCTGGGCCGC
GCGCCGCCACGGCGTGGCATGCACCATCGTCGTGCCGCACGGCAGCTCGGTGGAAAAGAACGCCGCCATGCGTGCCCTGG
GCGTGTCGCTCATCGAGCAAGGGCAGGACTTCCAGGAAGCGCGCGAGCACGCCATGCAGCTGGCCGCCGGGCGCGGCGCG
CACATGGTGCCGAGCTTCCATGCCGACCTGCTGCGCGGCGTGGCGACCTACTGGTGGGAGTTCCTGCGCGCCGTGCCGCG
CATGGACGTGGCCTACGTGCCCATCGGGCAGGGCTCGGGCGCCTGCTCGGCCCTCGCCGCGAAGCGGGCGCTGGGGCACG
GCGTGCGCATCGTGGGCGTGGTGAGCGCCCACGCCACCACCTATGCGGACTCGATCGCCGCCGGCCGCGTGGTGGAGGCG
CCCGTGTCCACGCTGCTCGCCGACGGCATGGCCTGCCGCGTGGCGGACCCGGAGGCCCTGGCCATCCTCGCGCCCGGCCT
GGACCACGTGGTGCGCGTGACCGACGACGAGGTGGCCGCCGCCATGCGCGCGCTGTTCGCCGACACGCACAACGTCGCCG
AGGGAGCGGGCGCCGCCGCCCTGGCGGCCGCGCTGCAGGAGCGGGGCCGGATCGCCGGGCAGGTGGTCGGGCTGCCGCTC
ACGGGCGGCAACGTGGACAGGCAGGTATTCGGGGATGTGCTGGGCGCCCCTGCGCATTGA

Upstream 100 bases:

>100_bases
TGCACGTCCCTGCCTTCGGAGAGCCGCCCATGATCTTCGCCTGCGCAGTCCCCCGCAGGCACTACTGCAAGATCCTCTTC
ACCGAACGAAAGGCCACGCC

Downstream 100 bases:

>100_bases
CGGGGCGGCAGACGACCGCCAGCGATCAACGATCAGCGGTCACTCAGCTGGACGTAGTTTTTACGCTCCTTGAATGGCTT
GTGGCCTTCCTCCACCATGG

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNAALPASAPDASARPHAALPSLADIEAAAEVVYADFAPTPQYRWALLGERLGAECWIKHENHTPVGAFKIRGGLTYFDQ
LARRGDMPREVISATRGNHGQSLGWAARRHGVACTIVVPHGSSVEKNAAMRALGVSLIEQGQDFQEAREHAMQLAAGRGA
HMVPSFHADLLRGVATYWWEFLRAVPRMDVAYVPIGQGSGACSALAAKRALGHGVRIVGVVSAHATTYADSIAAGRVVEA
PVSTLLADGMACRVADPEALAILAPGLDHVVRVTDDEVAAAMRALFADTHNVAEGAGAAALAAALQERGRIAGQVVGLPL
TGGNVDRQVFGDVLGAPAH

Sequences:

>Translated_339_residues
MNAALPASAPDASARPHAALPSLADIEAAAEVVYADFAPTPQYRWALLGERLGAECWIKHENHTPVGAFKIRGGLTYFDQ
LARRGDMPREVISATRGNHGQSLGWAARRHGVACTIVVPHGSSVEKNAAMRALGVSLIEQGQDFQEAREHAMQLAAGRGA
HMVPSFHADLLRGVATYWWEFLRAVPRMDVAYVPIGQGSGACSALAAKRALGHGVRIVGVVSAHATTYADSIAAGRVVEA
PVSTLLADGMACRVADPEALAILAPGLDHVVRVTDDEVAAAMRALFADTHNVAEGAGAAALAAALQERGRIAGQVVGLPL
TGGNVDRQVFGDVLGAPAH
>Mature_339_residues
MNAALPASAPDASARPHAALPSLADIEAAAEVVYADFAPTPQYRWALLGERLGAECWIKHENHTPVGAFKIRGGLTYFDQ
LARRGDMPREVISATRGNHGQSLGWAARRHGVACTIVVPHGSSVEKNAAMRALGVSLIEQGQDFQEAREHAMQLAAGRGA
HMVPSFHADLLRGVATYWWEFLRAVPRMDVAYVPIGQGSGACSALAAKRALGHGVRIVGVVSAHATTYADSIAAGRVVEA
PVSTLLADGMACRVADPEALAILAPGLDHVVRVTDDEVAAAMRALFADTHNVAEGAGAAALAAALQERGRIAGQVVGLPL
TGGNVDRQVFGDVLGAPAH

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=26.813880126183, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI19923959, Length=263, Percent_Identity=29.6577946768061, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790207, Length=297, Percent_Identity=29.96632996633, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=25.2336448598131, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI2367138, Length=132, Percent_Identity=32.5757575757576, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=328, Percent_Identity=27.7439024390244, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17537387, Length=316, Percent_Identity=28.4810126582279, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508781, Length=280, Percent_Identity=25.3571428571429, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=28.7974683544304, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320930, Length=276, Percent_Identity=30.0724637681159, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=29.7805642633229, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645328, Length=219, Percent_Identity=30.5936073059361, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35393; Mature: 35393

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAALPASAPDASARPHAALPSLADIEAAAEVVYADFAPTPQYRWALLGERLGAECWIKH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCEEEEEE
ENHTPVGAFKIRGGLTYFDQLARRGDMPREVISATRGNHGQSLGWAARRHGVACTIVVPH
CCCCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECC
GSSVEKNAAMRALGVSLIEQGQDFQEAREHAMQLAAGRGAHMVPSFHADLLRGVATYWWE
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FLRAVPRMDVAYVPIGQGSGACSALAAKRALGHGVRIVGVVSAHATTYADSIAAGRVVEA
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCCCHHHH
PVSTLLADGMACRVADPEALAILAPGLDHVVRVTDDEVAAAMRALFADTHNVAEGAGAAA
HHHHHHHCCCEEEECCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHH
LAAALQERGRIAGQVVGLPLTGGNVDRQVFGDVLGAPAH
HHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MNAALPASAPDASARPHAALPSLADIEAAAEVVYADFAPTPQYRWALLGERLGAECWIKH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCEEEEEE
ENHTPVGAFKIRGGLTYFDQLARRGDMPREVISATRGNHGQSLGWAARRHGVACTIVVPH
CCCCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECC
GSSVEKNAAMRALGVSLIEQGQDFQEAREHAMQLAAGRGAHMVPSFHADLLRGVATYWWE
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FLRAVPRMDVAYVPIGQGSGACSALAAKRALGHGVRIVGVVSAHATTYADSIAAGRVVEA
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCCCHHHH
PVSTLLADGMACRVADPEALAILAPGLDHVVRVTDDEVAAAMRALFADTHNVAEGAGAAA
HHHHHHHCCCEEEECCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHH
LAAALQERGRIAGQVVGLPLTGGNVDRQVFGDVLGAPAH
HHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]