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The map label for this gene is lysN [H]

Identifier: 120613073

GI number: 120613073

Start: 4931981

End: 4933177

Strand: Direct

Name: lysN [H]

Synonym: Aave_4437

Alternate gene names: 120613073

Gene position: 4931981-4933177 (Clockwise)

Preceding gene: 120613072

Following gene: 120613074

Centisome position: 92.14

GC content: 71.43

Gene sequence:

>1197_bases
ATGACGACCTGGACCCTGGCCCGACGCGCCGCGAAGATGAACCCCTCGGTGATCCGCGAGATCCTGAAGGTGACCGAGAA
GCCCGGCATCATCAGCCTGGCGGGCGGCCTGCCCTCCCCCAAGACCTTCCCGGTCGATGACTTCGCGCAGGCCTGCGCGG
CGGTGCTGGGCAACGACGGAGCCTCCGCGCTGCAGTACGCCGCGAGCGAGGGCTACCTGCCGCTGCGCGAGGCCGTGGCG
GATTTCCTGCCCTGGGACGTGTCGCCCGACCAGATCCTGATCACCACCGGCTCGCAGCAGGGCCTGGACCTGGTGGCCAA
GGTGCTCATCGACGCGGGAAGCCGCGTGCTGGTGGAAACCCCGACCTACCTCGGCGCCCTGCAGGCCTTCACGCCCATGG
AGCCCGACGTGCACAGCGTGGCGAGCGACGACGAAGGCCCGCTGGTGGACGACCTGGCCGCCAAGGTGGGCACGGGCGCG
GACCGCGCGCGCTTCATGTATCTGCTGCCCAACTTCCAGAACCCCACGGGCCGCACGATGACCGAGGCGCGCCGCGCAGC
GCTGTCGGCCAAAGCCGCCGAGCTGGGCCTGCCGCTGGTGGAGGACAACCCCTACGGCGACCTCTGGTTCGACCAGCCCC
CGCCGCTGCCGCTCACCGCCCGCAACCCGGAAGGCTGCATCTACCTGGGCTCGTTCTCCAAGGTGCTGGCCCCCGGCCTG
CGCCTGGGCTTCCTGGTGGCCCCGCGCGCCCTCTACCCCAAGCTGCTGCAGGCCAAGCAGGCGGCCGACCTGCACACCCC
CGGATTCAACCAGCGCATGGTGGCCGAGGTGATGAAGGGCGGCTTCCTGGACCGCCACGTGCCCACCATCCGCGCGCTCT
ACAAGCAGCAGCGCGACGCGATGCTCTCGGCCATGGACCGCGAGATGCAGGGACTGGGCGTGACCTGGAACCGCCCCGAC
GGCGGCATGTTCCTCTGGGCGCGCCTGCCGGAAGGCATGAGCGCGCTGGACCTGCTGCCCGAGGCCGTGGAGCGCAACGT
GGCCTTCGTGCCCGGCGCGGCGTTCTATGCGGACAATGCCGACGCGCGCACGCTGCGCCTGTCCTTCGTCACCGCGAGCG
CGCAGCAGATCCAGGACGGCATCGCCGCGCTGGCCGCCGCCATCCGCGCGCGCCTGCCCCAGTCCGTGGAGGCCTGA

Upstream 100 bases:

>100_bases
TGCCCCCCGACCGGCCGCACGACGGCTTTTTTCGACAATGACGACACACGAACGAGGCACGGCCTTTCCTTCCACGGGCC
TGCCGCAGGAGATGATTTCC

Downstream 100 bases:

>100_bases
CGCCATGCTGCGGCTCTGGGGACGGACGTCGTCCATCAACGTGCGCAAGGTCGTCTGGGCCGCGCAGGAGCTGTCGCTGG
AGCTGCAGCGCACCGACGCG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTTWTLARRAAKMNPSVIREILKVTEKPGIISLAGGLPSPKTFPVDDFAQACAAVLGNDGASALQYAASEGYLPLREAVA
DFLPWDVSPDQILITTGSQQGLDLVAKVLIDAGSRVLVETPTYLGALQAFTPMEPDVHSVASDDEGPLVDDLAAKVGTGA
DRARFMYLLPNFQNPTGRTMTEARRAALSAKAAELGLPLVEDNPYGDLWFDQPPPLPLTARNPEGCIYLGSFSKVLAPGL
RLGFLVAPRALYPKLLQAKQAADLHTPGFNQRMVAEVMKGGFLDRHVPTIRALYKQQRDAMLSAMDREMQGLGVTWNRPD
GGMFLWARLPEGMSALDLLPEAVERNVAFVPGAAFYADNADARTLRLSFVTASAQQIQDGIAALAAAIRARLPQSVEA

Sequences:

>Translated_398_residues
MTTWTLARRAAKMNPSVIREILKVTEKPGIISLAGGLPSPKTFPVDDFAQACAAVLGNDGASALQYAASEGYLPLREAVA
DFLPWDVSPDQILITTGSQQGLDLVAKVLIDAGSRVLVETPTYLGALQAFTPMEPDVHSVASDDEGPLVDDLAAKVGTGA
DRARFMYLLPNFQNPTGRTMTEARRAALSAKAAELGLPLVEDNPYGDLWFDQPPPLPLTARNPEGCIYLGSFSKVLAPGL
RLGFLVAPRALYPKLLQAKQAADLHTPGFNQRMVAEVMKGGFLDRHVPTIRALYKQQRDAMLSAMDREMQGLGVTWNRPD
GGMFLWARLPEGMSALDLLPEAVERNVAFVPGAAFYADNADARTLRLSFVTASAQQIQDGIAALAAAIRARLPQSVEA
>Mature_397_residues
TTWTLARRAAKMNPSVIREILKVTEKPGIISLAGGLPSPKTFPVDDFAQACAAVLGNDGASALQYAASEGYLPLREAVAD
FLPWDVSPDQILITTGSQQGLDLVAKVLIDAGSRVLVETPTYLGALQAFTPMEPDVHSVASDDEGPLVDDLAAKVGTGAD
RARFMYLLPNFQNPTGRTMTEARRAALSAKAAELGLPLVEDNPYGDLWFDQPPPLPLTARNPEGCIYLGSFSKVLAPGLR
LGFLVAPRALYPKLLQAKQAADLHTPGFNQRMVAEVMKGGFLDRHVPTIRALYKQQRDAMLSAMDREMQGLGVTWNRPDG
GMFLWARLPEGMSALDLLPEAVERNVAFVPGAAFYADNADARTLRLSFVTASAQQIQDGIAALAAAIRARLPQSVEA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=427, Percent_Identity=32.0843091334895, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI33469970, Length=427, Percent_Identity=32.0843091334895, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1787710, Length=382, Percent_Identity=27.4869109947644, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790797, Length=376, Percent_Identity=25.7978723404255, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI48994949, Length=395, Percent_Identity=24.5569620253165, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788722, Length=338, Percent_Identity=24.5562130177515, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321000, Length=441, Percent_Identity=25.1700680272109, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321929, Length=460, Percent_Identity=23.9130434782609, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356535, Length=399, Percent_Identity=24.5614035087719, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 42810; Mature: 42678

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTWTLARRAAKMNPSVIREILKVTEKPGIISLAGGLPSPKTFPVDDFAQACAAVLGNDG
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCC
ASALQYAASEGYLPLREAVADFLPWDVSPDQILITTGSQQGLDLVAKVLIDAGSRVLVET
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEC
PTYLGALQAFTPMEPDVHSVASDDEGPLVDDLAAKVGTGADRARFMYLLPNFQNPTGRTM
CHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHH
TEARRAALSAKAAELGLPLVEDNPYGDLWFDQPPPLPLTARNPEGCIYLGSFSKVLAPGL
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEECCCCCCEEEECCCHHHHCCCH
RLGFLVAPRALYPKLLQAKQAADLHTPGFNQRMVAEVMKGGFLDRHVPTIRALYKQQRDA
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MLSAMDREMQGLGVTWNRPDGGMFLWARLPEGMSALDLLPEAVERNVAFVPGAAFYADNA
HHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCEECCCC
DARTLRLSFVTASAQQIQDGIAALAAAIRARLPQSVEA
CCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTWTLARRAAKMNPSVIREILKVTEKPGIISLAGGLPSPKTFPVDDFAQACAAVLGNDG
CCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCC
ASALQYAASEGYLPLREAVADFLPWDVSPDQILITTGSQQGLDLVAKVLIDAGSRVLVET
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEC
PTYLGALQAFTPMEPDVHSVASDDEGPLVDDLAAKVGTGADRARFMYLLPNFQNPTGRTM
CHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHH
TEARRAALSAKAAELGLPLVEDNPYGDLWFDQPPPLPLTARNPEGCIYLGSFSKVLAPGL
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEECCCCCCEEEECCCHHHHCCCH
RLGFLVAPRALYPKLLQAKQAADLHTPGFNQRMVAEVMKGGFLDRHVPTIRALYKQQRDA
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MLSAMDREMQGLGVTWNRPDGGMFLWARLPEGMSALDLLPEAVERNVAFVPGAAFYADNA
HHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCEECCCC
DARTLRLSFVTASAQQIQDGIAALAAAIRARLPQSVEA
CCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA