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The map label for this gene is pepE [H]

Identifier: 120613000

GI number: 120613000

Start: 4849759

End: 4850472

Strand: Direct

Name: pepE [H]

Synonym: Aave_4364

Alternate gene names: 120613000

Gene position: 4849759-4850472 (Clockwise)

Preceding gene: 120612999

Following gene: 120613009

Centisome position: 90.6

GC content: 71.57

Gene sequence:

>714_bases
ATGAATCTCCTGCTTCTCAGCAATTCCAGCAGCGATGCCGGCTACCTCACCCATGCCCGGGGATGGATCGCCGACTGGGC
CGCCGCGCAGGCCCGTCACGGCGACGCGGTATTCATGCCCTTCGCGGGCGTGTCGCGCGGCTGGGACGATTACGAGGCCC
TGGTGGCCGGAGCGCTCGCGCCGCTCGGATTGGACGTGCGCTCGGCACACCGCGCAGCCGACCCGGTCGCCGCGGTAGCG
CAGGCCCGCTTCATCGTGACCGGCGGCGGCAACACCTTCGCCCTGCTGGGCCAATTGCGGCGGCTCGGCCTGCTCGGCGC
CATCGCTGCGCGTGTGCGCTCCGGCGAGGCCTCCTACCTGGGCTGGAGTGCCGGCTCCAACGTGGCCTGCCCGACCATAC
GCACCACCAATGACATGCCCATCACCGACCCGGGCGGCTTCGACGCCCTGGGCCTGGTGCCCTTCCAGATCAATGCACAC
TACACCGACGCGCACCCTCCGGGGCACCGCGGCGAAACCCGCGAAGAGCGCCTGCGCGAGTTCGGCCTGCTCAACCCTGG
TGCGCACGTGGTGGGTCTTCCGGAAGGTACCGGGCTGCGCGTGCATGGCGGCGCAGCCACCGTGCTGGGAGATACGGCAC
CCGTGCGCCTGTTCCTGGGCGCCGCGCCGGCACGCCTCCAGGGCCCCGGCCCCTTGGAGCTGCCACGGGCCTGA

Upstream 100 bases:

>100_bases
GAGCCCTCCGGGCCGCTATGCTCCGGACCGCAACCCCACCATCGATCCATGCCCACGCGCCCGCCCGGGACATGTGCCGG
CTTTCTCACACACCCCCACC

Downstream 100 bases:

>100_bases
AGCCCCGGTCCGGGCGAGCCGGTCTCAGGCCAGCGCGCGGGTGATGAGAATCTTCTGCACGTCGCTCGTGCCCTCGTAGA
TCTGGCACACGCGCACGTCG

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNLLLLSNSSSDAGYLTHARGWIADWAAAQARHGDAVFMPFAGVSRGWDDYEALVAGALAPLGLDVRSAHRAADPVAAVA
QARFIVTGGGNTFALLGQLRRLGLLGAIAARVRSGEASYLGWSAGSNVACPTIRTTNDMPITDPGGFDALGLVPFQINAH
YTDAHPPGHRGETREERLREFGLLNPGAHVVGLPEGTGLRVHGGAATVLGDTAPVRLFLGAAPARLQGPGPLELPRA

Sequences:

>Translated_237_residues
MNLLLLSNSSSDAGYLTHARGWIADWAAAQARHGDAVFMPFAGVSRGWDDYEALVAGALAPLGLDVRSAHRAADPVAAVA
QARFIVTGGGNTFALLGQLRRLGLLGAIAARVRSGEASYLGWSAGSNVACPTIRTTNDMPITDPGGFDALGLVPFQINAH
YTDAHPPGHRGETREERLREFGLLNPGAHVVGLPEGTGLRVHGGAATVLGDTAPVRLFLGAAPARLQGPGPLELPRA
>Mature_237_residues
MNLLLLSNSSSDAGYLTHARGWIADWAAAQARHGDAVFMPFAGVSRGWDDYEALVAGALAPLGLDVRSAHRAADPVAAVA
QARFIVTGGGNTFALLGQLRRLGLLGAIAARVRSGEASYLGWSAGSNVACPTIRTTNDMPITDPGGFDALGLVPFQINAH
YTDAHPPGHRGETREERLREFGLLNPGAHVVGLPEGTGLRVHGGAATVLGDTAPVRLFLGAAPARLQGPGPLELPRA

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=209, Percent_Identity=55.0239234449761, Blast_Score=219, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24641669, Length=199, Percent_Identity=46.2311557788945, Blast_Score=150, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 24620; Mature: 24620

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLLLSNSSSDAGYLTHARGWIADWAAAQARHGDAVFMPFAGVSRGWDDYEALVAGALA
CEEEEEECCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
PLGLDVRSAHRAADPVAAVAQARFIVTGGGNTFALLGQLRRLGLLGAIAARVRSGEASYL
HCCCCHHHHHHHCCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
GWSAGSNVACPTIRTTNDMPITDPGGFDALGLVPFQINAHYTDAHPPGHRGETREERLRE
EECCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHH
FGLLNPGAHVVGLPEGTGLRVHGGAATVLGDTAPVRLFLGAAPARLQGPGPLELPRA
CCCCCCCCEEEECCCCCCEEEECCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLLLLSNSSSDAGYLTHARGWIADWAAAQARHGDAVFMPFAGVSRGWDDYEALVAGALA
CEEEEEECCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
PLGLDVRSAHRAADPVAAVAQARFIVTGGGNTFALLGQLRRLGLLGAIAARVRSGEASYL
HCCCCHHHHHHHCCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
GWSAGSNVACPTIRTTNDMPITDPGGFDALGLVPFQINAHYTDAHPPGHRGETREERLRE
EECCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHH
FGLLNPGAHVVGLPEGTGLRVHGGAATVLGDTAPVRLFLGAAPARLQGPGPLELPRA
CCCCCCCCEEEECCCCCCEEEECCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA