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The map label for this gene is cynR [H]

Identifier: 120611782

GI number: 120611782

Start: 3445833

End: 3446780

Strand: Reverse

Name: cynR [H]

Synonym: Aave_3122

Alternate gene names: 120611782

Gene position: 3446780-3445833 (Counterclockwise)

Preceding gene: 120611785

Following gene: 120611780

Centisome position: 64.39

GC content: 69.51

Gene sequence:

>948_bases
TTGGCAATCCAGGCCGAACATGGACCGATGGCAGCTCCTTCCCTTCACAGCACTTCCATCCGCTATTTCCTGGAGGTGGC
CGGCAGCGGCTCGGTCCAGTTGGCCGCGTCGCGGCTTTTCGTGGCGCCCTCGGCGGTCAGCCGGCAGATCGCCAAGCTGG
AAGACATGCTCGGTGCATCGCTCTTCGAGCGCCAGCCCCGCGGCATGGCGCTGACGGCGGCAGGACAGCGGCTCGCTGCC
CACCTGCGCCATGCCGTGCTGGACGCGGAACACGTGATCGACCAGGTGCGGCAGCTCGGTCGCGAAACGTCGGCGCGCGT
GCGCCTGTGCTGCACCGAAGGTTTCGCCGCCGATTTCATGCCGGCCTTCATGCAGGACTATTGGCACGCCCAGCCCGGCA
GCCGGGTGGAACTGCAGGTCGGCGATCCCGGATCGGTCACGCAGTGGCTGCTGCGGGGCGAGGCGGACATCGGCCTCAAA
TACGCCGTGGCGCCGGAGCCCGGCCTGCAGGTGGAACATTCCTCGCGCGCGCCCGTCCTGGCCGTGATGGCCACGGGCCA
CCCCCTGGCGTCCCAGGACCGCGTGGCGCTGGCCGAGGTGGTGAAATACCCGCTGCTCGTGGGCAGCGCGGGCGTCACCG
CGCGGCAGCTTTTCGACCTCGCCTGCAACGCGCAAGGCCTGCGCTACCACGCGGAGTTCGTGAGCAATTTTTCATCGGTG
ATGCTGCCGTTGCTGCGCAGTCCGCAGATTTTGCTGTCCGGCCCGCTCAGTGTCGCGCACCGGGTGAGGGCGGGCGCGGT
GGTGGCCCGGCCCTTCGCGGGCGCGACCGTCCTGCACCAGCGCCGGCTGCAGGTGCTTTCGCTCGAAGGCCGCACATTGC
CCACACCCCTTCGCGCCTGTCTCGATGCCCTCCGGGGCGCCATCGAAAACGCCGGCGCGCTGCCCTGA

Upstream 100 bases:

>100_bases
ATCGGTGCATGGTCTGGGGGCTCCGGCAAAGGGTGCCCGCAAGTAAACCCCCGTCCACTGATTGCCGGAAGTGCCGTTTT
TACAGCAGGGCATTGCCTTT

Downstream 100 bases:

>100_bases
GGCCGCGGGACCGTCCCGCCGTCAGCCGCCCGAGCCGGTGGGGCCTGCGTCCCGGCACCGAGGACTGTCCGCGGACCGGA
ACGGGCTGTGCGCCTCCAGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAIQAEHGPMAAPSLHSTSIRYFLEVAGSGSVQLAASRLFVAPSAVSRQIAKLEDMLGASLFERQPRGMALTAAGQRLAA
HLRHAVLDAEHVIDQVRQLGRETSARVRLCCTEGFAADFMPAFMQDYWHAQPGSRVELQVGDPGSVTQWLLRGEADIGLK
YAVAPEPGLQVEHSSRAPVLAVMATGHPLASQDRVALAEVVKYPLLVGSAGVTARQLFDLACNAQGLRYHAEFVSNFSSV
MLPLLRSPQILLSGPLSVAHRVRAGAVVARPFAGATVLHQRRLQVLSLEGRTLPTPLRACLDALRGAIENAGALP

Sequences:

>Translated_315_residues
MAIQAEHGPMAAPSLHSTSIRYFLEVAGSGSVQLAASRLFVAPSAVSRQIAKLEDMLGASLFERQPRGMALTAAGQRLAA
HLRHAVLDAEHVIDQVRQLGRETSARVRLCCTEGFAADFMPAFMQDYWHAQPGSRVELQVGDPGSVTQWLLRGEADIGLK
YAVAPEPGLQVEHSSRAPVLAVMATGHPLASQDRVALAEVVKYPLLVGSAGVTARQLFDLACNAQGLRYHAEFVSNFSSV
MLPLLRSPQILLSGPLSVAHRVRAGAVVARPFAGATVLHQRRLQVLSLEGRTLPTPLRACLDALRGAIENAGALP
>Mature_314_residues
AIQAEHGPMAAPSLHSTSIRYFLEVAGSGSVQLAASRLFVAPSAVSRQIAKLEDMLGASLFERQPRGMALTAAGQRLAAH
LRHAVLDAEHVIDQVRQLGRETSARVRLCCTEGFAADFMPAFMQDYWHAQPGSRVELQVGDPGSVTQWLLRGEADIGLKY
AVAPEPGLQVEHSSRAPVLAVMATGHPLASQDRVALAEVVKYPLLVGSAGVTARQLFDLACNAQGLRYHAEFVSNFSSVM
LPLLRSPQILLSGPLSVAHRVRAGAVVARPFAGATVLHQRRLQVLSLEGRTLPTPLRACLDALRGAIENAGALP

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=268, Percent_Identity=29.8507462686567, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI145693105, Length=189, Percent_Identity=24.8677248677249, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788296, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787530, Length=241, Percent_Identity=24.4813278008299, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367136, Length=235, Percent_Identity=26.3829787234043, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787879, Length=195, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790208, Length=144, Percent_Identity=29.8611111111111, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788481, Length=210, Percent_Identity=28.0952380952381, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=209, Percent_Identity=24.4019138755981, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789173, Length=160, Percent_Identity=30.625, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788887, Length=190, Percent_Identity=27.8947368421053, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789440, Length=126, Percent_Identity=26.984126984127, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1787601, Length=141, Percent_Identity=27.6595744680851, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33678; Mature: 33547

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQAEHGPMAAPSLHSTSIRYFLEVAGSGSVQLAASRLFVAPSAVSRQIAKLEDMLGAS
CCEECCCCCCCCCCCCHHHHEEEEEECCCCCEEEEHHHHEECHHHHHHHHHHHHHHHHHH
LFERQPRGMALTAAGQRLAAHLRHAVLDAEHVIDQVRQLGRETSARVRLCCTEGFAADFM
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
PAFMQDYWHAQPGSRVELQVGDPGSVTQWLLRGEADIGLKYAVAPEPGLQVEHSSRAPVL
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCEEECCCCCCEE
AVMATGHPLASQDRVALAEVVKYPLLVGSAGVTARQLFDLACNAQGLRYHAEFVSNFSSV
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MLPLLRSPQILLSGPLSVAHRVRAGAVVARPFAGATVLHQRRLQVLSLEGRTLPTPLRAC
HHHHHCCCCEEEECCHHHHHHHHHCCEEECCCCCHHHHHHHHHHEEEECCCCCCHHHHHH
LDALRGAIENAGALP
HHHHHHHHHCCCCCC
>Mature Secondary Structure 
AIQAEHGPMAAPSLHSTSIRYFLEVAGSGSVQLAASRLFVAPSAVSRQIAKLEDMLGAS
CEECCCCCCCCCCCCHHHHEEEEEECCCCCEEEEHHHHEECHHHHHHHHHHHHHHHHHH
LFERQPRGMALTAAGQRLAAHLRHAVLDAEHVIDQVRQLGRETSARVRLCCTEGFAADFM
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
PAFMQDYWHAQPGSRVELQVGDPGSVTQWLLRGEADIGLKYAVAPEPGLQVEHSSRAPVL
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCEEECCCCCCEE
AVMATGHPLASQDRVALAEVVKYPLLVGSAGVTARQLFDLACNAQGLRYHAEFVSNFSSV
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MLPLLRSPQILLSGPLSVAHRVRAGAVVARPFAGATVLHQRRLQVLSLEGRTLPTPLRAC
HHHHHCCCCEEEECCHHHHHHHHHCCEEECCCCCHHHHHHHHHHEEEECCCCCCHHHHHH
LDALRGAIENAGALP
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]