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The map label for this gene is ilvC

Identifier: 120611770

GI number: 120611770

Start: 3434759

End: 3435775

Strand: Reverse

Name: ilvC

Synonym: Aave_3110

Alternate gene names: 120611770

Gene position: 3435775-3434759 (Counterclockwise)

Preceding gene: 120611771

Following gene: 120611769

Centisome position: 64.19

GC content: 63.91

Gene sequence:

>1017_bases
ATGAAAGTTTTCTACGACAAGGACTGTGACCTGAGCCTGATCAAGGGCAAGACCGTGGCCATCATCGGCTACGGCTCGCA
GGGCCATGCCCACGCACAGAACCTGAACGACAGCGGCGTGAAGGTCGTGGTCGGCCTGCGCAAGGGCGGTGCGTCCTGGG
ACAAGGTCGGCAAGGCCGGCCTGACGGTGCTCGAAGTGAACGAGGCCGTGAAGTCCGCCGATGTCGTCATGATCCTGCTG
CCCGACGAGCAGATCGCCGAGGTGTACAAGAACAACGTCGAGCCGAACATCAAGCAGGGCGCTTCCCTGGCGTTCGCGCA
CGGCTTCAACGTGCACTACAACCAGGTGGTGCCCCGCGCCGACCTGGACGTGTGGATGGTGGCCCCGAAGGCCCCGGGCC
ACACGGTGCGCTCCACCTACAGCCAGGGCGGCGGCGTACCCCACCTGGTGGCCGTGCACCAGGACAAGTCCGGCAAGGCC
CGCGACCTGGCCCTGTCCTACGCCATGGCCAACGGTGGCGGCAAGGCCGGCATCATCGAGACCAACTTCAAGGAAGAGAC
CGAGACCGATCTGTTCGGCGAGCAGGCCGTGCTGTGCGGCGGCGCGGTCGAGCTGATCAAGATGGGCTTCGAGACGCTCG
TGGAAGCCGGCTATGCCCCCGAAATGGCCTACTTCGAATGCCTGCACGAGCTCAAGCTCATCGTGGACCTGATCTACGAA
GGCGGCATCGCCAACATGAACTATTCCATCTCGAACAACGCCGAGTTCGGCGAGTACGTGACGGGCCCCGAGGTCATCAA
CGAGCAGTCGCGCGCGGCCATGCGCAATGCGCTCAAGCGCATCCAGAACGGCGACTACGCGAAGATGTTCATCCAGGAAG
GCCGCCTGAACTACCCGAGCATGACGGCCCGCCGCCGCAACACGGCCGACCACAAGATCGAGGTCGTGGGTGCGCAACTG
CGCGCGATGATGCCCTGGATCGCCAAGAACAAGCTCGTGGACCAGAGCCGCAACTGA

Upstream 100 bases:

>100_bases
CCGGCGCCTGCGGCATCGGGCGCGGCGAGCGCATCCTCCGCGTCTAGCCACGCATCCCTCATACATCTTTTCTTCACCGA
TTCAACCTGGAGCCAACAAC

Downstream 100 bases:

>100_bases
TCTTTGTCCGCCGTGGCGCGCCACGCGGTCCTGCAAGGCCACCCGCCCGGGTGGCCTTTCTTTCTTTTCGGGGGCCGGTT
CGGAGCGTTCTACACTCCAC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVFYDKDCDLSLIKGKTVAIIGYGSQGHAHAQNLNDSGVKVVVGLRKGGASWDKVGKAGLTVLEVNEAVKSADVVMILL
PDEQIAEVYKNNVEPNIKQGASLAFAHGFNVHYNQVVPRADLDVWMVAPKAPGHTVRSTYSQGGGVPHLVAVHQDKSGKA
RDLALSYAMANGGGKAGIIETNFKEETETDLFGEQAVLCGGAVELIKMGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEFGEYVTGPEVINEQSRAAMRNALKRIQNGDYAKMFIQEGRLNYPSMTARRRNTADHKIEVVGAQL
RAMMPWIAKNKLVDQSRN

Sequences:

>Translated_338_residues
MKVFYDKDCDLSLIKGKTVAIIGYGSQGHAHAQNLNDSGVKVVVGLRKGGASWDKVGKAGLTVLEVNEAVKSADVVMILL
PDEQIAEVYKNNVEPNIKQGASLAFAHGFNVHYNQVVPRADLDVWMVAPKAPGHTVRSTYSQGGGVPHLVAVHQDKSGKA
RDLALSYAMANGGGKAGIIETNFKEETETDLFGEQAVLCGGAVELIKMGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEFGEYVTGPEVINEQSRAAMRNALKRIQNGDYAKMFIQEGRLNYPSMTARRRNTADHKIEVVGAQL
RAMMPWIAKNKLVDQSRN
>Mature_338_residues
MKVFYDKDCDLSLIKGKTVAIIGYGSQGHAHAQNLNDSGVKVVVGLRKGGASWDKVGKAGLTVLEVNEAVKSADVVMILL
PDEQIAEVYKNNVEPNIKQGASLAFAHGFNVHYNQVVPRADLDVWMVAPKAPGHTVRSTYSQGGGVPHLVAVHQDKSGKA
RDLALSYAMANGGGKAGIIETNFKEETETDLFGEQAVLCGGAVELIKMGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEFGEYVTGPEVINEQSRAAMRNALKRIQNGDYAKMFIQEGRLNYPSMTARRRNTADHKIEVVGAQL
RAMMPWIAKNKLVDQSRN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=285, Percent_Identity=36.8421052631579, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=325, Percent_Identity=31.6923076923077, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ACIAC (A1TRT6)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971448.1
- ProteinModelPortal:   A1TRT6
- SMR:   A1TRT6
- STRING:   A1TRT6
- GeneID:   4665217
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3110
- NMPDR:   fig|397945.5.peg.2650
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   A1TRT6
- ProtClustDB:   PRK05479
- BioCyc:   AAVE397945:AAVE_3110-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36862; Mature: 36862

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFYDKDCDLSLIKGKTVAIIGYGSQGHAHAQNLNDSGVKVVVGLRKGGASWDKVGKAG
CCEEECCCCCEEEECCCEEEEEEECCCCCHHHCCCCCCCCEEEEEEECCCCCHHHHHHCC
LTVLEVNEAVKSADVVMILLPDEQIAEVYKNNVEPNIKQGASLAFAHGFNVHYNQVVPRA
CEEEEEHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHCCCCCC
DLDVWMVAPKAPGHTVRSTYSQGGGVPHLVAVHQDKSGKARDLALSYAMANGGGKAGIIE
CCCEEEECCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEECCCCCEEEEE
TNFKEETETDLFGEQAVLCGGAVELIKMGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
CCCCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEFGEYVTGPEVINEQSRAAMRNALKRIQNGDYAKMFIQEGRLNYPS
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
MTARRRNTADHKIEVVGAQLRAMMPWIAKNKLVDQSRN
CHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVFYDKDCDLSLIKGKTVAIIGYGSQGHAHAQNLNDSGVKVVVGLRKGGASWDKVGKAG
CCEEECCCCCEEEECCCEEEEEEECCCCCHHHCCCCCCCCEEEEEEECCCCCHHHHHHCC
LTVLEVNEAVKSADVVMILLPDEQIAEVYKNNVEPNIKQGASLAFAHGFNVHYNQVVPRA
CEEEEEHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHCCCCCC
DLDVWMVAPKAPGHTVRSTYSQGGGVPHLVAVHQDKSGKARDLALSYAMANGGGKAGIIE
CCCEEEECCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEECCCCCEEEEE
TNFKEETETDLFGEQAVLCGGAVELIKMGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
CCCCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEFGEYVTGPEVINEQSRAAMRNALKRIQNGDYAKMFIQEGRLNYPS
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
MTARRRNTADHKIEVVGAQLRAMMPWIAKNKLVDQSRN
CHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA