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The map label for this gene is thiD [H]

Identifier: 120611729

GI number: 120611729

Start: 3380772

End: 3381671

Strand: Reverse

Name: thiD [H]

Synonym: Aave_3067

Alternate gene names: 120611729

Gene position: 3381671-3380772 (Counterclockwise)

Preceding gene: 120611734

Following gene: 120611728

Centisome position: 63.18

GC content: 73.11

Gene sequence:

>900_bases
ATGAATTCCAAGCCTCTCGAACCACGGCCGGCTGCATGCGCCGTGGAAGGACCCCGATACGTGCGCGTCCTGTCCATCGC
CGGGTCCGACAGCGGAGGCGGGGCGGGCATCCAGGCCGACCTGAAGACCTTCGCCGCCCTGGGCTGCTACGGAATGACCG
CCATCACGGCCATCACCGCCCAGAACACGCAGGGCGTACGCTCCATCCACGGAGTGCCCGCCGCCATCCTGGGCGACCAG
ATCGACGCGGTGGTGGAAGACATCGGCGTGGATGCCGTCAAGATCGGCATGCTGCATGCTCCGGAGGTCGCCGAGGTGGT
GGCCGACGCGATCCGCCGGCACGCGCTGCCCCACGTGGTGCTCGACCCCGTCATGGTGGCCACCAGCGGCGATCGCCTCA
TCGCGCCGGACACCGTGCGCGTGCTGGTGAAGGCGCTGTTTCCGCTGGCTGCGGTGGTGACGCCGAACCTCGACGAGGCG
GGCATGCTGCTGGGCCGCGCCATCCAGGACGAGAGCGCCATGGACGCCGCGGCGCGGGAGCTGCTGGGCCTCGGCGCCCA
GGCCGTGCTGCTCAAGGGCGGCCACCTGCCGGGCGACGCGCTGGTGGATGTCCTGGCCGTGCGGGGCGTGGCGCAGCACC
TGCGCCTGCGGTCCGCGCGCATCCCGACGCGCAACGGCCATGGCACGGGCTGCACGCTGTCGTCCGCGATCGCCGCCCAC
CTGGCCCTGGGCAGCGGACTGCGCGAAGCTGTGGCCGCCGCGCATGCCTACGTCCAGGCGGCGATCGCCGCCGGGGCACC
GGTGCGCACGGGCCGCGGCGCAGGTCCGCTCGACCATGGGCATGCGCCCGTGGCGCAGCGCATCCACCGCGACCCGGCCG
CGACCGGGGGATCCCTGTGA

Upstream 100 bases:

>100_bases
GCCCGGCGGGCGCGGCACCCCTGTTTCGTCCGTTCCCTGAATTACAGCACAGCGCTGCGGAAGGCGTATTTGATATCGCG
CATGCGCCATAATTTTTGCC

Downstream 100 bases:

>100_bases
GCGGCCGCCCGCCGCGCCAGGGGGAAGCCGCATGAGTCTCCGCGCTCCGGACCCGGGGCACATCCGGGACGCCTTCTCCA
CGCAGGACGCGCTCGTGCAG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNSKPLEPRPAACAVEGPRYVRVLSIAGSDSGGGAGIQADLKTFAALGCYGMTAITAITAQNTQGVRSIHGVPAAILGDQ
IDAVVEDIGVDAVKIGMLHAPEVAEVVADAIRRHALPHVVLDPVMVATSGDRLIAPDTVRVLVKALFPLAAVVTPNLDEA
GMLLGRAIQDESAMDAAARELLGLGAQAVLLKGGHLPGDALVDVLAVRGVAQHLRLRSARIPTRNGHGTGCTLSSAIAAH
LALGSGLREAVAAAHAYVQAAIAAGAPVRTGRGAGPLDHGHAPVAQRIHRDPAATGGSL

Sequences:

>Translated_299_residues
MNSKPLEPRPAACAVEGPRYVRVLSIAGSDSGGGAGIQADLKTFAALGCYGMTAITAITAQNTQGVRSIHGVPAAILGDQ
IDAVVEDIGVDAVKIGMLHAPEVAEVVADAIRRHALPHVVLDPVMVATSGDRLIAPDTVRVLVKALFPLAAVVTPNLDEA
GMLLGRAIQDESAMDAAARELLGLGAQAVLLKGGHLPGDALVDVLAVRGVAQHLRLRSARIPTRNGHGTGCTLSSAIAAH
LALGSGLREAVAAAHAYVQAAIAAGAPVRTGRGAGPLDHGHAPVAQRIHRDPAATGGSL
>Mature_299_residues
MNSKPLEPRPAACAVEGPRYVRVLSIAGSDSGGGAGIQADLKTFAALGCYGMTAITAITAQNTQGVRSIHGVPAAILGDQ
IDAVVEDIGVDAVKIGMLHAPEVAEVVADAIRRHALPHVVLDPVMVATSGDRLIAPDTVRVLVKALFPLAAVVTPNLDEA
GMLLGRAIQDESAMDAAARELLGLGAQAVLLKGGHLPGDALVDVLAVRGVAQHLRLRSARIPTRNGHGTGCTLSSAIAAH
LALGSGLREAVAAAHAYVQAAIAAGAPVRTGRGAGPLDHGHAPVAQRIHRDPAATGGSL

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=265, Percent_Identity=43.3962264150943, Blast_Score=210, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6325378, Length=271, Percent_Identity=35.4243542435424, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324997, Length=272, Percent_Identity=37.8676470588235, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324517, Length=272, Percent_Identity=37.1323529411765, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30260; Mature: 30260

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKPLEPRPAACAVEGPRYVRVLSIAGSDSGGGAGIQADLKTFAALGCYGMTAITAITA
CCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
QNTQGVRSIHGVPAAILGDQIDAVVEDIGVDAVKIGMLHAPEVAEVVADAIRRHALPHVV
CCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHH
LDPVMVATSGDRLIAPDTVRVLVKALFPLAAVVTPNLDEAGMLLGRAIQDESAMDAAARE
HCCEEEEECCCCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHH
LLGLGAQAVLLKGGHLPGDALVDVLAVRGVAQHLRLRSARIPTRNGHGTGCTLSSAIAAH
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LALGSGLREAVAAAHAYVQAAIAAGAPVRTGRGAGPLDHGHAPVAQRIHRDPAATGGSL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNSKPLEPRPAACAVEGPRYVRVLSIAGSDSGGGAGIQADLKTFAALGCYGMTAITAITA
CCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
QNTQGVRSIHGVPAAILGDQIDAVVEDIGVDAVKIGMLHAPEVAEVVADAIRRHALPHVV
CCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHH
LDPVMVATSGDRLIAPDTVRVLVKALFPLAAVVTPNLDEAGMLLGRAIQDESAMDAAARE
HCCEEEEECCCCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHH
LLGLGAQAVLLKGGHLPGDALVDVLAVRGVAQHLRLRSARIPTRNGHGTGCTLSSAIAAH
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LALGSGLREAVAAAHAYVQAAIAAGAPVRTGRGAGPLDHGHAPVAQRIHRDPAATGGSL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]