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The map label for this gene is tcmP [H]

Identifier: 120611726

GI number: 120611726

Start: 3375116

End: 3375979

Strand: Reverse

Name: tcmP [H]

Synonym: Aave_3064

Alternate gene names: 120611726

Gene position: 3375979-3375116 (Counterclockwise)

Preceding gene: 120611727

Following gene: 120611723

Centisome position: 63.07

GC content: 74.54

Gene sequence:

>864_bases
GTGCCTGCCGTGCCACCTGAAGGGCCGGTCGGCCTCGCCGGGACCTGGGAGGCCCTGCGCGGCAGTTCCGCCACCCTGGC
GCTCACCCTGAGCGCGCGGGCCTCCCCGCTGGCACGCGAGGCCGACGCCGCATGGGTGGATCCCTGGGCCGCGCCGCTGC
TGGCGCAGTGCCCCTGGGACCTGCGCCGCGCGGCGGACGACCCCGCGCTGGTGCGGGCCGTGGTGGCGCGCGGCCTGGTC
TTCGACCGCCTGGTGCTGCAGGCCTGCGCCGAGCGGCCTGTCCACGCCGTGCTCAGCCTGGGCGCGGGGCTCTGCACCCG
GCAGGGCCGGCTGGCGCCGTCCTTGCCGGGCGTCGAATGGATCGATGCCGACCTGCCGGAAGTCATCGCCCTGCGGCGCC
TGCTCCTGCCTTCCGTCGCGGCCCCGGGCTCGGGCCGGCTGGTTCCCGGTACCCTGCAGGACGACACCTGGCTGGAGGCC
ATGCCCTGGCAGGAAGGCCGGAGCTTCCTCGTGCTGCTCGAAGGCGTGGCGCCCTATGTGCCCCCGGCGGACATCCGGCA
TCTGCTCGAGCGGCTCGCGGCGCGTGCGCGGCGCGCAGGCTGCGGCTGCCGCGTGGTGCTGGATTACCTGCATCCGGATT
TCGTGCCGATCGCCGCCTGGCAGGCGGGCCCCGCCATGTTGCCGGTGGTCAGCGGCTTCCGCGATGCCGCCGCGCTGGTG
GAGGGGGGCACGGGCTTTCGCGTGCTGCAGGAATGCCGGCCCTTCGGCCTGTTTTCCGAAGCGCACCGCCGGTTCGAGGA
CGAATTCCGCGGGCGCCATGGCCACGTGCCCTATGCCGTGGCCTGCCTGGAATCTGCCTCTTGA

Upstream 100 bases:

>100_bases
CGTGCTGAACTATCCCAACGCGCCCGAGGCCCGGGATTTCTGGCCGATCTCGCTCACGTCGTACAACAACACCGGCAGCG
CCTATCCGTTCACCTGCTGA

Downstream 100 bases:

>100_bases
GCCGTTCCGACAGAGCCAGGAGACAACGTCGGGAGTGTCTGGCTTGAGAGCGGCTGACACGACCCAGCGAAGCGGTTCTG
GCTAGGCGCCGCATCGCAGG

Product: polyketide biosynthesis O-methyltransferase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPAVPPEGPVGLAGTWEALRGSSATLALTLSARASPLAREADAAWVDPWAAPLLAQCPWDLRRAADDPALVRAVVARGLV
FDRLVLQACAERPVHAVLSLGAGLCTRQGRLAPSLPGVEWIDADLPEVIALRRLLLPSVAAPGSGRLVPGTLQDDTWLEA
MPWQEGRSFLVLLEGVAPYVPPADIRHLLERLAARARRAGCGCRVVLDYLHPDFVPIAAWQAGPAMLPVVSGFRDAAALV
EGGTGFRVLQECRPFGLFSEAHRRFEDEFRGRHGHVPYAVACLESAS

Sequences:

>Translated_287_residues
MPAVPPEGPVGLAGTWEALRGSSATLALTLSARASPLAREADAAWVDPWAAPLLAQCPWDLRRAADDPALVRAVVARGLV
FDRLVLQACAERPVHAVLSLGAGLCTRQGRLAPSLPGVEWIDADLPEVIALRRLLLPSVAAPGSGRLVPGTLQDDTWLEA
MPWQEGRSFLVLLEGVAPYVPPADIRHLLERLAARARRAGCGCRVVLDYLHPDFVPIAAWQAGPAMLPVVSGFRDAAALV
EGGTGFRVLQECRPFGLFSEAHRRFEDEFRGRHGHVPYAVACLESAS
>Mature_286_residues
PAVPPEGPVGLAGTWEALRGSSATLALTLSARASPLAREADAAWVDPWAAPLLAQCPWDLRRAADDPALVRAVVARGLVF
DRLVLQACAERPVHAVLSLGAGLCTRQGRLAPSLPGVEWIDADLPEVIALRRLLLPSVAAPGSGRLVPGTLQDDTWLEAM
PWQEGRSFLVLLEGVAPYVPPADIRHLLERLAARARRAGCGCRVVLDYLHPDFVPIAAWQAGPAMLPVVSGFRDAAALVE
GGTGFRVLQECRPFGLFSEAHRRFEDEFRGRHGHVPYAVACLESAS

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: COG3315

COG function: function code Q; O-Methyltransferase involved in polyketide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 30770; Mature: 30639

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVPPEGPVGLAGTWEALRGSSATLALTLSARASPLAREADAAWVDPWAAPLLAQCPWD
CCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHCCHH
LRRAADDPALVRAVVARGLVFDRLVLQACAERPVHAVLSLGAGLCTRQGRLAPSLPGVEW
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
IDADLPEVIALRRLLLPSVAAPGSGRLVPGTLQDDTWLEAMPWQEGRSFLVLLEGVAPYV
HCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEEECCCCCC
PPADIRHLLERLAARARRAGCGCRVVLDYLHPDFVPIAAWQAGPAMLPVVSGFRDAAALV
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
EGGTGFRVLQECRPFGLFSEAHRRFEDEFRGRHGHVPYAVACLESAS
CCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
PAVPPEGPVGLAGTWEALRGSSATLALTLSARASPLAREADAAWVDPWAAPLLAQCPWD
CCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHCCHH
LRRAADDPALVRAVVARGLVFDRLVLQACAERPVHAVLSLGAGLCTRQGRLAPSLPGVEW
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
IDADLPEVIALRRLLLPSVAAPGSGRLVPGTLQDDTWLEAMPWQEGRSFLVLLEGVAPYV
HCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEEECCCCCC
PPADIRHLLERLAARARRAGCGCRVVLDYLHPDFVPIAAWQAGPAMLPVVSGFRDAAALV
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
EGGTGFRVLQECRPFGLFSEAHRRFEDEFRGRHGHVPYAVACLESAS
CCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]