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The map label for this gene is rsbRA [H]

Identifier: 120611633

GI number: 120611633

Start: 3260896

End: 3261753

Strand: Direct

Name: rsbRA [H]

Synonym: Aave_2970

Alternate gene names: 120611633

Gene position: 3260896-3261753 (Clockwise)

Preceding gene: 120611620

Following gene: 120611634

Centisome position: 60.92

GC content: 69.23

Gene sequence:

>858_bases
ATGACTCTGCAGTACGAGGCCCTTCTGGACATCCTGGATCGCAAGGAAGAGGCCATCACCCAGGAATGGCTGGCCGAGGC
GGCCCAGGGCAATGCCCTGCACTCTCCCACCGCCGTCTCGGACGCGCGCGACATCCTGCAAGCGCTGCGCACCGCGCTGC
AGAGCACGCCGCCGCCCGCCGGCCACCCGCAGGCGGGCAGCGCATGGCACACGCTCAACGGCGTGCTGGAGTCCCTGTCG
CGCTCCCGGGCCGCGCGCGGCGAGACCGCCGGCGACACCAGCCTGTTCGTGCTGGCGCTCAAGAAGGCCCTGTTCACCCA
GCTGCAGGCGACATCGCAGGACACCACCGCCCTGCAGGCCGCGCTGTGGAACACCACCGCTCTGGTGGACCGGATGGCGC
AGCACACGGTCAACACCTTCCAGCAGGCGCGCGAGGACATCATCCGCCGCCAGCAGGAAGAACTTCTGGAACTCTCGACC
CCGGTGGTCAAGCTCTGGGATGGCGTGCTCGCCGTGCCGATGATCGGCACGCTCGACAGCAACCGCACCCAGGTGGTGAT
GGAAACGCTGCTGCAGCGCATCGTGGACACCGGATCCGACATCGCCATCATCGACATCACCGGCGTGCCCACGGTGGACA
CGCTGGTCGCGCAGCACCTGCTCAAGACGGTGGCCGCCATCCGGCTCATGGGCGCCGACTGCATCGTGAGCGGCATCCGG
CCGCAGATCGCGCAGACCATCGTGCACCTGGGCATCGACCTGCAGGGCATCCACACGCGCGCCACGCTCGCGGACGCGCT
CGCCCTCGCGCTGCAGAAAAGCGGCTGGCGCATCGAGCGCGACCGCGCGCCCACCTGA

Upstream 100 bases:

>100_bases
TCGGAGAGTTCCGTAAAAGCCGCCCCTGCCCCCCGGACGGACATGCCCCCGCCCTTAGAATTTGACACATCTACAACATC
GAGCGAAAGCGCCCCCGGCC

Downstream 100 bases:

>100_bases
GCGGAAGGACACGCATGGAACGCATACCGATCCTCCGCATGGGCAACACCCTGCTGGTCACCATCCAGGTGGACATGCAG
GACCGCACCGCCCTCGCGCT

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTLQYEALLDILDRKEEAITQEWLAEAAQGNALHSPTAVSDARDILQALRTALQSTPPPAGHPQAGSAWHTLNGVLESLS
RSRAARGETAGDTSLFVLALKKALFTQLQATSQDTTALQAALWNTTALVDRMAQHTVNTFQQAREDIIRRQQEELLELST
PVVKLWDGVLAVPMIGTLDSNRTQVVMETLLQRIVDTGSDIAIIDITGVPTVDTLVAQHLLKTVAAIRLMGADCIVSGIR
PQIAQTIVHLGIDLQGIHTRATLADALALALQKSGWRIERDRAPT

Sequences:

>Translated_285_residues
MTLQYEALLDILDRKEEAITQEWLAEAAQGNALHSPTAVSDARDILQALRTALQSTPPPAGHPQAGSAWHTLNGVLESLS
RSRAARGETAGDTSLFVLALKKALFTQLQATSQDTTALQAALWNTTALVDRMAQHTVNTFQQAREDIIRRQQEELLELST
PVVKLWDGVLAVPMIGTLDSNRTQVVMETLLQRIVDTGSDIAIIDITGVPTVDTLVAQHLLKTVAAIRLMGADCIVSGIR
PQIAQTIVHLGIDLQGIHTRATLADALALALQKSGWRIERDRAPT
>Mature_284_residues
TLQYEALLDILDRKEEAITQEWLAEAAQGNALHSPTAVSDARDILQALRTALQSTPPPAGHPQAGSAWHTLNGVLESLSR
SRAARGETAGDTSLFVLALKKALFTQLQATSQDTTALQAALWNTTALVDRMAQHTVNTFQQAREDIIRRQQEELLELSTP
VVKLWDGVLAVPMIGTLDSNRTQVVMETLLQRIVDTGSDIAIIDITGVPTVDTLVAQHLLKTVAAIRLMGADCIVSGIRP
QIAQTIVHLGIDLQGIHTRATLADALALALQKSGWRIERDRAPT

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 30907; Mature: 30776

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQYEALLDILDRKEEAITQEWLAEAAQGNALHSPTAVSDARDILQALRTALQSTPPPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GHPQAGSAWHTLNGVLESLSRSRAARGETAGDTSLFVLALKKALFTQLQATSQDTTALQA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALWNTTALVDRMAQHTVNTFQQAREDIIRRQQEELLELSTPVVKLWDGVLAVPMIGTLDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCC
NRTQVVMETLLQRIVDTGSDIAIIDITGVPTVDTLVAQHLLKTVAAIRLMGADCIVSGIR
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PQIAQTIVHLGIDLQGIHTRATLADALALALQKSGWRIERDRAPT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
TLQYEALLDILDRKEEAITQEWLAEAAQGNALHSPTAVSDARDILQALRTALQSTPPPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GHPQAGSAWHTLNGVLESLSRSRAARGETAGDTSLFVLALKKALFTQLQATSQDTTALQA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALWNTTALVDRMAQHTVNTFQQAREDIIRRQQEELLELSTPVVKLWDGVLAVPMIGTLDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCC
NRTQVVMETLLQRIVDTGSDIAIIDITGVPTVDTLVAQHLLKTVAAIRLMGADCIVSGIR
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PQIAQTIVHLGIDLQGIHTRATLADALALALQKSGWRIERDRAPT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]