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The map label for this gene is ppiD [C]

Identifier: 120611614

GI number: 120611614

Start: 3240504

End: 3241301

Strand: Direct

Name: ppiD [C]

Synonym: Aave_2951

Alternate gene names: 120611614

Gene position: 3240504-3241301 (Clockwise)

Preceding gene: 120611613

Following gene: 120611618

Centisome position: 60.54

GC content: 62.66

Gene sequence:

>798_bases
GTGGATTTCCCAATGAAGAAAAAGCTCTTGTCCGGCCTCGTGGCCGCTGCCGTGCTGGGCACGTCCGCCCTGCCCGCCAT
CGCGCAGAACATCGCCGTCGTGAACGGCAAGGCCGTGCCCAAGGAACGTGTCGAAGTCCTGAAGCAGCAGGTCGAACGCT
CCGGCCGGCCGATCACCCCCGAAATCGAAGGCCAGATCAAGGAAGAAGTGATCGCCCGCGAAATCTTCCTGCAGGAAGCG
CAGAAGCGCGGACTGGAAGGCTCGCAGAACGTGAAGGACCAGATGGAACTGGCCCGCCAGACCATCCTGATCCGCGAGCT
GTTCGCCGACTACCAGAAGGCCAACCCCGTCACCGACGCCGATATCCAGGCCGAGTACGACAAGTTCGTCGCCGCGAACA
CCGGCAAGGAATACAAGGCCAGCCACATCCTGGTGGAAACCGAAGACCAGGCCAAGTCCATCATCGCGTCCATCAAGAAG
GGCGCGAAGTTCGAGGACATCGCCAAGAAGCAGTCCAAGGATCCCGGATCCGGCGCACGCGGCGGTGATCTCGACTGGGC
CACCCCGAGCAGCTACGTGTCCGAGTTCACCGAGGCCCTCGTGAAGCTCGACAAGGGCAAGATGACGCAGACCCCGGTCA
AGACGCAGTTCGGCTGGCACGTCATCCGCCTGGACGACGTGCGCGAAGCCAAGCTGCCCAAGCTGGACGAAGTCAAGGCG
CAGATCGCCCAGCAGCTGCAGCAGCAGAAGCTGGCCAAGTTCCAGGAAGACCTGCGCGCCAAGGCCAAGGTCGAGTGA

Upstream 100 bases:

>100_bases
CAGGGTGCGCACGCCATCGCGATTGAAGTTCTCTGATCGTCTGATTCCCACGTCCAGGGCCACCGTGGCGCACACCGTGC
AGCCGGCCCTTTTCCTTTTT

Downstream 100 bases:

>100_bases
TCGGCGACGGGCTGCAGTGCTCGTCGGTTCCATCGAAAAACGCGGCCAAGGCCGCGTTTTTTCATGCGCAGCCCTCCGGC
CCCGTCAGCGGCCCAGCATC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MDFPMKKKLLSGLVAAAVLGTSALPAIAQNIAVVNGKAVPKERVEVLKQQVERSGRPITPEIEGQIKEEVIAREIFLQEA
QKRGLEGSQNVKDQMELARQTILIRELFADYQKANPVTDADIQAEYDKFVAANTGKEYKASHILVETEDQAKSIIASIKK
GAKFEDIAKKQSKDPGSGARGGDLDWATPSSYVSEFTEALVKLDKGKMTQTPVKTQFGWHVIRLDDVREAKLPKLDEVKA
QIAQQLQQQKLAKFQEDLRAKAKVE

Sequences:

>Translated_265_residues
MDFPMKKKLLSGLVAAAVLGTSALPAIAQNIAVVNGKAVPKERVEVLKQQVERSGRPITPEIEGQIKEEVIAREIFLQEA
QKRGLEGSQNVKDQMELARQTILIRELFADYQKANPVTDADIQAEYDKFVAANTGKEYKASHILVETEDQAKSIIASIKK
GAKFEDIAKKQSKDPGSGARGGDLDWATPSSYVSEFTEALVKLDKGKMTQTPVKTQFGWHVIRLDDVREAKLPKLDEVKA
QIAQQLQQQKLAKFQEDLRAKAKVE
>Mature_265_residues
MDFPMKKKLLSGLVAAAVLGTSALPAIAQNIAVVNGKAVPKERVEVLKQQVERSGRPITPEIEGQIKEEVIAREIFLQEA
QKRGLEGSQNVKDQMELARQTILIRELFADYQKANPVTDADIQAEYDKFVAANTGKEYKASHILVETEDQAKSIIASIKK
GAKFEDIAKKQSKDPGSGARGGDLDWATPSSYVSEFTEALVKLDKGKMTQTPVKTQFGWHVIRLDDVREAKLPKLDEVKA
QIAQQLQQQKLAKFQEDLRAKAKVE

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=136, Percent_Identity=36.0294117647059, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786238, Length=103, Percent_Identity=44.6601941747573, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29382; Mature: 29382

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFPMKKKLLSGLVAAAVLGTSALPAIAQNIAVVNGKAVPKERVEVLKQQVERSGRPITP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
EIEGQIKEEVIAREIFLQEAQKRGLEGSQNVKDQMELARQTILIRELFADYQKANPVTDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DIQAEYDKFVAANTGKEYKASHILVETEDQAKSIIASIKKGAKFEDIAKKQSKDPGSGAR
HHHHHHHHHHHCCCCCCHHHCEEEEECHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
GGDLDWATPSSYVSEFTEALVKLDKGKMTQTPVKTQFGWHVIRLDDVREAKLPKLDEVKA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHH
QIAQQLQQQKLAKFQEDLRAKAKVE
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFPMKKKLLSGLVAAAVLGTSALPAIAQNIAVVNGKAVPKERVEVLKQQVERSGRPITP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCC
EIEGQIKEEVIAREIFLQEAQKRGLEGSQNVKDQMELARQTILIRELFADYQKANPVTDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DIQAEYDKFVAANTGKEYKASHILVETEDQAKSIIASIKKGAKFEDIAKKQSKDPGSGAR
HHHHHHHHHHHCCCCCCHHHCEEEEECHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
GGDLDWATPSSYVSEFTEALVKLDKGKMTQTPVKTQFGWHVIRLDDVREAKLPKLDEVKA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHH
QIAQQLQQQKLAKFQEDLRAKAKVE
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]