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The map label for this gene is pcm3 [H]

Identifier: 120611480

GI number: 120611480

Start: 3089275

End: 3089985

Strand: Direct

Name: pcm3 [H]

Synonym: Aave_2816

Alternate gene names: 120611480

Gene position: 3089275-3089985 (Clockwise)

Preceding gene: 120611479

Following gene: 120611481

Centisome position: 57.71

GC content: 70.18

Gene sequence:

>711_bases
ATGACCCTCCCCCTGAACACGACCGCCGACGCGAACGACCCCGTGACGCTGGCCCGCTACAACATGATCGAGCAGCAGAT
CCGCCCGTGGAACGTGCTCGATGCCGATGTGCTGGACCTGCTGGGCACCGTGCGCCGCGAGGATTTCGTGCCCCCCGCCT
ACCGCGGCATGGCGTTCATGGACATGGAGATCCCGCTCAACCCCTCCGCCGAGGAAGCCCAGCGCCTGGGCCAGTGCATG
CTGGCTCCGCGCGTGGAAGCCCGCCTGCTGCAGGACCTGCAGGTCAAGCCGACCGACCGCGTGCTGGAGATCGGCGCCGG
CTCCGGCTACATGGCGGCCCTGCTCGCGCACCGCGCCGAGCACGTGGTCACGCTGGAAATCGTGCCCGACCTGGTGGAAT
TCGCCCGCGAGAACCTGCTGAGCGCCGGCATCGACAACGTGGCGGTGCGCCAGGGCGACGGCGCACGAGACGCCATCCCG
GACGGCCCGTTCGACGTCATCGTGCTGAGCGGCTCGGTACACGAAGTGCCGCAGCACCTGCTGGCGCTGCTGCGCGAAGG
CGGCCGCCTGGCCGCGATCACCGGCGACGAGCCCGTGATGCGCGCCACCTTCGTGCGCCGCACGGGCGACCGCTTCGCCA
CGACCCATCCCTGGGACACCAACGTCCCGCGCCTGCAGCATTTCGCGGAGCGCCCACGCTTCACGTTCTGA

Upstream 100 bases:

>100_bases
GCGCCAGGACGCGCCCGCTGCCCAACCGCGGGCGAAGCGGGCGGTACGCGCGCCTAAAATGGATGGTTTGTCCTGACCCC
GTGCACCGGAGAAATCCCCC

Downstream 100 bases:

>100_bases
GCGCCTTCCCTTCCCGACACGGCATCGCCCTTCCATGATCGACCACGTACGTCCCTCCCAGCTCGACGAATGGTTCTCCG
CCCAGGCCGGCGGCGGACGC

Product: type 11 methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase 3; Protein L-isoaspartyl methyltransferase 3; Protein-beta-aspartate methyltransferase 3; PIMT 3 [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTLPLNTTADANDPVTLARYNMIEQQIRPWNVLDADVLDLLGTVRREDFVPPAYRGMAFMDMEIPLNPSAEEAQRLGQCM
LAPRVEARLLQDLQVKPTDRVLEIGAGSGYMAALLAHRAEHVVTLEIVPDLVEFARENLLSAGIDNVAVRQGDGARDAIP
DGPFDVIVLSGSVHEVPQHLLALLREGGRLAAITGDEPVMRATFVRRTGDRFATTHPWDTNVPRLQHFAERPRFTF

Sequences:

>Translated_236_residues
MTLPLNTTADANDPVTLARYNMIEQQIRPWNVLDADVLDLLGTVRREDFVPPAYRGMAFMDMEIPLNPSAEEAQRLGQCM
LAPRVEARLLQDLQVKPTDRVLEIGAGSGYMAALLAHRAEHVVTLEIVPDLVEFARENLLSAGIDNVAVRQGDGARDAIP
DGPFDVIVLSGSVHEVPQHLLALLREGGRLAAITGDEPVMRATFVRRTGDRFATTHPWDTNVPRLQHFAERPRFTF
>Mature_235_residues
TLPLNTTADANDPVTLARYNMIEQQIRPWNVLDADVLDLLGTVRREDFVPPAYRGMAFMDMEIPLNPSAEEAQRLGQCML
APRVEARLLQDLQVKPTDRVLEIGAGSGYMAALLAHRAEHVVTLEIVPDLVEFARENLLSAGIDNVAVRQGDGARDAIPD
GPFDVIVLSGSVHEVPQHLLALLREGGRLAAITGDEPVMRATFVRRTGDRFATTHPWDTNVPRLQHFAERPRFTF

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789100, Length=194, Percent_Identity=35.0515463917526, Blast_Score=107, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 26180; Mature: 26049

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPLNTTADANDPVTLARYNMIEQQIRPWNVLDADVLDLLGTVRREDFVPPAYRGMAFM
CCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCEEEE
DMEIPLNPSAEEAQRLGQCMLAPRVEARLLQDLQVKPTDRVLEIGAGSGYMAALLAHRAE
EEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHH
HVVTLEIVPDLVEFARENLLSAGIDNVAVRQGDGARDAIPDGPFDVIVLSGSVHEVPQHL
HEEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHH
LALLREGGRLAAITGDEPVMRATFVRRTGDRFATTHPWDTNVPRLQHFAERPRFTF
HHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLPLNTTADANDPVTLARYNMIEQQIRPWNVLDADVLDLLGTVRREDFVPPAYRGMAFM
CCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCEEEE
DMEIPLNPSAEEAQRLGQCMLAPRVEARLLQDLQVKPTDRVLEIGAGSGYMAALLAHRAE
EEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHH
HVVTLEIVPDLVEFARENLLSAGIDNVAVRQGDGARDAIPDGPFDVIVLSGSVHEVPQHL
HEEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHH
LALLREGGRLAAITGDEPVMRATFVRRTGDRFATTHPWDTNVPRLQHFAERPRFTF
HHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA