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The map label for this gene is metC [H]

Identifier: 120610814

GI number: 120610814

Start: 2351896

End: 2353086

Strand: Reverse

Name: metC [H]

Synonym: Aave_2139

Alternate gene names: 120610814

Gene position: 2353086-2351896 (Counterclockwise)

Preceding gene: 120610816

Following gene: 120610812

Centisome position: 43.96

GC content: 62.8

Gene sequence:

>1191_bases
ATGCATCACGATACACCCCGGACCTTCCTGTCCCAGCCCATCGCTGGCACGGAAACCGATGATCCTGCCTCGACACTTCC
CCCGGTCCACCGCGCGTCCACCATTTTCCTGCCGACCCTGTCGCATCTGAAAAGCGCCGACTGGCGCAACCGCAGCCAAC
CACCCTACGGCAGAGATGGTTCCCGCGCCGCATGCGAACTGGAAACCAGGCTTGCACATATCGAAGGTGCCCGGCAAGCG
CTCGTGGTGTCTTCCGGGCTCGCGGCATACGCGCTGATCTGCATGGCGCTGCTGTCTCCCGGCGACGTCGTTGCGATGCC
GACGAACGGCTATGGCACCGCGCAGCAAATGCTGCGGAACGTATTTCACCGCTTCGGCATCGGAATTGTGCTGTACGACC
CCATGGCGCCCGACACCTGGGCCGAGGCCGTTCCCCCTTCCACCCGCCTGTTGTGCGTGGAGGCACCGGGCTCGGTCACC
ATGGAGGTTCCGGATCTTCGGCGCCTCGCCGGGCTGGCAGGTGAACGGGGGTGCATCGCCGCGATCGACAACACGTACAG
CGCAGGACTGCATCTGCGTGCGTTTGAACTCGGCTTCCATGTGTCCGTCCAGGCACTGACCAAACTCCAGTCCGGTGGTG
CCGATCTGGTGATGGGGAGCGTGGGCAGCGTGCGCGAGGACATCTCCCGCAGTCTTTGCGAAACACGCCATTTTCTCGGA
ATGCATGTCTCGCCGGATGATATTTATCTGGTGCTCCGGGGCCTGCCCACGCTGAGCCTTCGGTACGCGGCCAACACGGA
AGCGTCCTTGCGCCTCGCGGAGTGGTTTTCGGAGAAGAAGGAGATCGCGGCCGTCATGCATCCGGCTTTCCGCGGCAGCC
AGGGCCACGACCATTGGAAACGGTATTTCACGGGTGCCACCAGCCTGTTCAGCATTGCCTTCGACGCATCGGTCGAAACC
GAAAAGATAGAGGCGTTTCTCGAAGCCCTGACCCTCTTTCACTTTGGCTTCTCGTGGGGAGGTCCGACAAGCCTGGTCAT
GTTGTACGGCAGGGAGAGCGCATCCACGCGGCATTTCGAAAGAAGCCATCCCGGGGCGGGTTGCATCGCGCGGTTTTGGC
TCGGCCTGGAAGACGGAGGCGATCTGGCGGCGGACGTAGCCAACGCCTGGTCATCGGCCTTCGACGCATAG

Upstream 100 bases:

>100_bases
GGAATCCGCCCACTTGCCCGAAAGCACCGGGTAATTTTTAGTTATCGTGAATCGCCTCAAGCCTCGTTACCCTTCCACGT
AGATACCATCTTCAACCTGG

Downstream 100 bases:

>100_bases
CGGGCTCAGCCCAGCACACTCAGCACGAGGCCGATCGTCACGAACAATGTGCAGGCCAGCCGCATCCCGACCACTTTCTC
CTTCAGGAAGACGGCACCGA

Product: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MHHDTPRTFLSQPIAGTETDDPASTLPPVHRASTIFLPTLSHLKSADWRNRSQPPYGRDGSRAACELETRLAHIEGARQA
LVVSSGLAAYALICMALLSPGDVVAMPTNGYGTAQQMLRNVFHRFGIGIVLYDPMAPDTWAEAVPPSTRLLCVEAPGSVT
MEVPDLRRLAGLAGERGCIAAIDNTYSAGLHLRAFELGFHVSVQALTKLQSGGADLVMGSVGSVREDISRSLCETRHFLG
MHVSPDDIYLVLRGLPTLSLRYAANTEASLRLAEWFSEKKEIAAVMHPAFRGSQGHDHWKRYFTGATSLFSIAFDASVET
EKIEAFLEALTLFHFGFSWGGPTSLVMLYGRESASTRHFERSHPGAGCIARFWLGLEDGGDLAADVANAWSSAFDA

Sequences:

>Translated_396_residues
MHHDTPRTFLSQPIAGTETDDPASTLPPVHRASTIFLPTLSHLKSADWRNRSQPPYGRDGSRAACELETRLAHIEGARQA
LVVSSGLAAYALICMALLSPGDVVAMPTNGYGTAQQMLRNVFHRFGIGIVLYDPMAPDTWAEAVPPSTRLLCVEAPGSVT
MEVPDLRRLAGLAGERGCIAAIDNTYSAGLHLRAFELGFHVSVQALTKLQSGGADLVMGSVGSVREDISRSLCETRHFLG
MHVSPDDIYLVLRGLPTLSLRYAANTEASLRLAEWFSEKKEIAAVMHPAFRGSQGHDHWKRYFTGATSLFSIAFDASVET
EKIEAFLEALTLFHFGFSWGGPTSLVMLYGRESASTRHFERSHPGAGCIARFWLGLEDGGDLAADVANAWSSAFDA
>Mature_396_residues
MHHDTPRTFLSQPIAGTETDDPASTLPPVHRASTIFLPTLSHLKSADWRNRSQPPYGRDGSRAACELETRLAHIEGARQA
LVVSSGLAAYALICMALLSPGDVVAMPTNGYGTAQQMLRNVFHRFGIGIVLYDPMAPDTWAEAVPPSTRLLCVEAPGSVT
MEVPDLRRLAGLAGERGCIAAIDNTYSAGLHLRAFELGFHVSVQALTKLQSGGADLVMGSVGSVREDISRSLCETRHFLG
MHVSPDDIYLVLRGLPTLSLRYAANTEASLRLAEWFSEKKEIAAVMHPAFRGSQGHDHWKRYFTGATSLFSIAFDASVET
EKIEAFLEALTLFHFGFSWGGPTSLVMLYGRESASTRHFERSHPGAGCIARFWLGLEDGGDLAADVANAWSSAFDA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=30.6122448979592, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI299473759, Length=247, Percent_Identity=29.5546558704453, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI25453487, Length=293, Percent_Identity=26.6211604095563, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789383, Length=365, Percent_Identity=32.8767123287671, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1790375, Length=375, Percent_Identity=26.4, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17538055, Length=333, Percent_Identity=29.7297297297297, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17560056, Length=318, Percent_Identity=27.3584905660377, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71980708, Length=369, Percent_Identity=25.2032520325203, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321170, Length=315, Percent_Identity=33.015873015873, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319307, Length=398, Percent_Identity=25.3768844221106, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=284, Percent_Identity=25, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321904, Length=394, Percent_Identity=23.6040609137056, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321254, Length=409, Percent_Identity=23.2273838630807, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922554, Length=398, Percent_Identity=30.1507537688442, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42959; Mature: 42959

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHDTPRTFLSQPIAGTETDDPASTLPPVHRASTIFLPTLSHLKSADWRNRSQPPYGRDG
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCC
SRAACELETRLAHIEGARQALVVSSGLAAYALICMALLSPGDVVAMPTNGYGTAQQMLRN
CCHHHHHHHHHHHHHCHHHEEEHHCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
VFHRFGIGIVLYDPMAPDTWAEAVPPSTRLLCVEAPGSVTMEVPDLRRLAGLAGERGCIA
HHHHHCCCEEEECCCCCCCHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHCCCCCCEEE
AIDNTYSAGLHLRAFELGFHVSVQALTKLQSGGADLVMGSVGSVREDISRSLCETRHFLG
EECCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
MHVSPDDIYLVLRGLPTLSLRYAANTEASLRLAEWFSEKKEIAAVMHPAFRGSQGHDHWK
CCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RYFTGATSLFSIAFDASVETEKIEAFLEALTLFHFGFSWGGPTSLVMLYGRESASTRHFE
HHHHCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHH
RSHPGAGCIARFWLGLEDGGDLAADVANAWSSAFDA
HCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHHDTPRTFLSQPIAGTETDDPASTLPPVHRASTIFLPTLSHLKSADWRNRSQPPYGRDG
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCC
SRAACELETRLAHIEGARQALVVSSGLAAYALICMALLSPGDVVAMPTNGYGTAQQMLRN
CCHHHHHHHHHHHHHCHHHEEEHHCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
VFHRFGIGIVLYDPMAPDTWAEAVPPSTRLLCVEAPGSVTMEVPDLRRLAGLAGERGCIA
HHHHHCCCEEEECCCCCCCHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHCCCCCCEEE
AIDNTYSAGLHLRAFELGFHVSVQALTKLQSGGADLVMGSVGSVREDISRSLCETRHFLG
EECCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
MHVSPDDIYLVLRGLPTLSLRYAANTEASLRLAEWFSEKKEIAAVMHPAFRGSQGHDHWK
CCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RYFTGATSLFSIAFDASVETEKIEAFLEALTLFHFGFSWGGPTSLVMLYGRESASTRHFE
HHHHCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHH
RSHPGAGCIARFWLGLEDGGDLAADVANAWSSAFDA
HCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]