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The map label for this gene is fsr [H]

Identifier: 120610801

GI number: 120610801

Start: 2337544

End: 2338839

Strand: Reverse

Name: fsr [H]

Synonym: Aave_2124

Alternate gene names: 120610801

Gene position: 2338839-2337544 (Counterclockwise)

Preceding gene: 120610802

Following gene: 120610800

Centisome position: 43.69

GC content: 69.44

Gene sequence:

>1296_bases
ATGACCACCACGACCGCTGATACCGCGCAGCCCGCGCACCTCGCCCCCCTTGCCGCTCCTGTCGCTCCCGACGCTGCTGC
CACGACCACGGCCACGGCCACCCCGCCGCTGCAGGACGCCACGGCCCATGGCTTCCTGCTCCCCATCGTCGGCAGCGCAG
CCTTCGCCCATCTGCTCAACGACATGATCCAGGCGATGCTGCCGTCGATCTTCCCGATGCTGAAAGCGAATTTCTCGCTG
AGCTTCGGGCAGATCGGGATCATCGCGCTGGTCTACCAGGTGACGGCGTCGCTGCTGCAGCCGTGGATCGGGTTCTATAC
CGACAAGCACCCCAAGCCCTACCTGCTGCCGGCGGGCATGTGCATGACGCTGCTGGGCGTCGCGCTGCTGGCCGTGGCGC
ACAGCTATCCGATGCTGCTGGTCGCGGCCGCGGTGGTGGGCGTGGGCTCGGCCACGTTCCACCCGGAGGCGTCGCGGATC
GCGCGGCTGGCCTCGGGCGGGCGGTTCGGCACGGCGCAGTCCACGTTCCAGGTGGGCGGCAACACGGGCACGGCGATCGG
GCCGCTGCTGACGGCGGCCATCGTGATTCCGCACGGCCAGCCGGCGGTCGCGTGGTTCATGGCGGCGGCGTTGCTGGCGA
TCTTCGTGCTGTACCGGCTCACGGTGTGGGTGCGCCACCATGGGGCGGCGAAGGCCCGCGGGCTGGCGCGGGGCGGCAGC
GAGGGGCTGGACCGGGCCGGCGTGGTGCGGGCGGTGGCCGTGATCTGCGTGCTGATGTTCGCGAAGTTCGTCTATATCGC
TTCGTTCACCAACTACTTCACGTTCTACCTGATCGAGCGCTTCCACGTCAGCGTGCAGACGAGCCAGATGTTCCTTTTCC
TGTTTCTCGCGGCCGTGGCGGCGGGCACGTTCGCGGGCGGGCCCGTGGGCGACCGCATCGGCCGCAAGGCGGTGATCTGG
ATCTCGTTCCTGGGCGTGGCTCCGTTCGCGCTGGCGCTGCCGCATGTGGGCCTCGCGTGGACGGCGGTGCTCGCGGTCGT
GATCGGGCTGGTGATGTCTTCCGCCTTCGCCGCGCTCGTGGTGTATGCGCAGGAGGCCGTGCCGGGCCGCGTGGGGCTGG
TGTCGGGCCTGATGTTCGGATTGATGTTCGGCATCGGCGGGATCGGGGCGGCCGGGCTCGGTGACCTGGCGGACATCCAC
GGCATCGTGTGGGTGTATGGCGTGACGTCTTTCCTGCCGCTGCTGGGGCTGGCGACGGCCTTGCTGCCCGATACGCGCAA
AAAAGCACGGGCCTGA

Upstream 100 bases:

>100_bases
ATCCGCGTACGCTCACCGCTTCTTCCCGCTATCGCCGCCCTGCCCTCTTCGCCCAGCAGGGCAGCGGCTACCGGCCGCCA
GAGCCTTTGTCTGCCCCACG

Downstream 100 bases:

>100_bases
GCTGGCGCGCCCTGCGCCATGGCCGCCCGCCCGGCTCCTGGGTGCCCTCGTCCTACGCGACGACGGGCCGCGCCGCTGGC
GCGGACGCGGGGCGGACGGT

Product: major facilitator superfamily transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTTTTADTAQPAHLAPLAAPVAPDAAATTTATATPPLQDATAHGFLLPIVGSAAFAHLLNDMIQAMLPSIFPMLKANFSL
SFGQIGIIALVYQVTASLLQPWIGFYTDKHPKPYLLPAGMCMTLLGVALLAVAHSYPMLLVAAAVVGVGSATFHPEASRI
ARLASGGRFGTAQSTFQVGGNTGTAIGPLLTAAIVIPHGQPAVAWFMAAALLAIFVLYRLTVWVRHHGAAKARGLARGGS
EGLDRAGVVRAVAVICVLMFAKFVYIASFTNYFTFYLIERFHVSVQTSQMFLFLFLAAVAAGTFAGGPVGDRIGRKAVIW
ISFLGVAPFALALPHVGLAWTAVLAVVIGLVMSSAFAALVVYAQEAVPGRVGLVSGLMFGLMFGIGGIGAAGLGDLADIH
GIVWVYGVTSFLPLLGLATALLPDTRKKARA

Sequences:

>Translated_431_residues
MTTTTADTAQPAHLAPLAAPVAPDAAATTTATATPPLQDATAHGFLLPIVGSAAFAHLLNDMIQAMLPSIFPMLKANFSL
SFGQIGIIALVYQVTASLLQPWIGFYTDKHPKPYLLPAGMCMTLLGVALLAVAHSYPMLLVAAAVVGVGSATFHPEASRI
ARLASGGRFGTAQSTFQVGGNTGTAIGPLLTAAIVIPHGQPAVAWFMAAALLAIFVLYRLTVWVRHHGAAKARGLARGGS
EGLDRAGVVRAVAVICVLMFAKFVYIASFTNYFTFYLIERFHVSVQTSQMFLFLFLAAVAAGTFAGGPVGDRIGRKAVIW
ISFLGVAPFALALPHVGLAWTAVLAVVIGLVMSSAFAALVVYAQEAVPGRVGLVSGLMFGLMFGIGGIGAAGLGDLADIH
GIVWVYGVTSFLPLLGLATALLPDTRKKARA
>Mature_430_residues
TTTTADTAQPAHLAPLAAPVAPDAAATTTATATPPLQDATAHGFLLPIVGSAAFAHLLNDMIQAMLPSIFPMLKANFSLS
FGQIGIIALVYQVTASLLQPWIGFYTDKHPKPYLLPAGMCMTLLGVALLAVAHSYPMLLVAAAVVGVGSATFHPEASRIA
RLASGGRFGTAQSTFQVGGNTGTAIGPLLTAAIVIPHGQPAVAWFMAAALLAIFVLYRLTVWVRHHGAAKARGLARGGSE
GLDRAGVVRAVAVICVLMFAKFVYIASFTNYFTFYLIERFHVSVQTSQMFLFLFLAAVAAGTFAGGPVGDRIGRKAVIWI
SFLGVAPFALALPHVGLAWTAVLAVVIGLVMSSAFAALVVYAQEAVPGRVGLVSGLMFGLMFGIGGIGAAGLGDLADIHG
IVWVYGVTSFLPLLGLATALLPDTRKKARA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=410, Percent_Identity=53.6585365853659, Blast_Score=394, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44751; Mature: 44620

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTTADTAQPAHLAPLAAPVAPDAAATTTATATPPLQDATAHGFLLPIVGSAAFAHLLN
CCCCCCCCCCCCHHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DMIQAMLPSIFPMLKANFSLSFGQIGIIALVYQVTASLLQPWIGFYTDKHPKPYLLPAGM
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
CMTLLGVALLAVAHSYPMLLVAAAVVGVGSATFHPEASRIARLASGGRFGTAQSTFQVGG
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECC
NTGTAIGPLLTAAIVIPHGQPAVAWFMAAALLAIFVLYRLTVWVRHHGAAKARGLARGGS
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
EGLDRAGVVRAVAVICVLMFAKFVYIASFTNYFTFYLIERFHVSVQTSQMFLFLFLAAVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFAGGPVGDRIGRKAVIWISFLGVAPFALALPHVGLAWTAVLAVVIGLVMSSAFAALV
HCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VYAQEAVPGRVGLVSGLMFGLMFGIGGIGAAGLGDLADIHGIVWVYGVTSFLPLLGLATA
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPDTRKKARA
HCCCHHHHCCC
>Mature Secondary Structure 
TTTTADTAQPAHLAPLAAPVAPDAAATTTATATPPLQDATAHGFLLPIVGSAAFAHLLN
CCCCCCCCCCCHHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH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HCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]