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The map label for this gene is cobA [H]

Identifier: 120610780

GI number: 120610780

Start: 2304944

End: 2305804

Strand: Reverse

Name: cobA [H]

Synonym: Aave_2103

Alternate gene names: 120610780

Gene position: 2305804-2304944 (Counterclockwise)

Preceding gene: 120610781

Following gene: 120610779

Centisome position: 43.08

GC content: 73.17

Gene sequence:

>861_bases
ATGAACCGTTCCGTCCCTCCCTCGCAGACCGCCCCCACCGCACCGGCCCGCCCCTATGGCGCCGCGCCGCGCGGCACCTG
CACGCTCGTCGGCGCGGGACCGGGCGACCCCGAACTGCTCACCCTCAAGGCCCTCAAGGCCATCCAGGCGGCCACCGTGC
TGCTGGTGGACGACCTCGTCAGCGACGAGATCGTCGCCCTCGCCGCGCCCGGTGCGCGGGTGGTGCACGTCGGCAAGCGC
GGCGGCTGCAAGAGCACGCCGCAGGCCTTCATCGAGAAGCTCATGGTCATGGCCGTGAACGAAGGCGAGAACGTGGTGCG
GCTCAAGGGCGGCGATCCTTTCATCTTCGGGCGCGGCGGCGAAGAGGTCGAGCACCTGCGCGCGGCCGGCATCGAGGTCA
CCGTGGTCAACGGCATCACGGCCGGCCTGGCGGGCATGACCCTGCTCGGCACGCCGCTCACGCACCGCGAGCACGCCCAC
GGCGTGGTCTTCGTCACCGGCCACGCCAAGCCCGGCGACAGCGGCATCGACTGGCGCCAGCTCGCCGCCACGGCCCGCGC
CGCGCGCCTGACGCTGGTGATCTACATGGGCGTGAGCAGCGCCGCGCACATCCAGGAAGAATTGCTCACCGGCCTGCCGG
CCTGCACCCCCGTGGTCATCATCCAGCACGTGAGCCTGCCCTGCCAGCGCCACGCGCTCACCACGCTGGGCGAGCTGCAC
GCCACCATCGAGCGCGAACAGCTCGGCAGTCCCTCGGTCATCGTGGTGGGCGACGTGGCCGCCGGCGTGGCAGCCGCGGC
CGGCGACGGCCTGGGACAGCCCCTGCCGGTGGCGCCACCGCCGCTGCGGCACGCCGGCTGA

Upstream 100 bases:

>100_bases
AGCAGGTGCTCGCGGGCGAACTGCCCGTGCCCGCCCCGCTCTCCCGGCAGGTGGAACACATCTTGCGTCTTGCCCGCCAG
AACTCCACGGAGACAGCCCC

Downstream 100 bases:

>100_bases
AGGCGCCAGCGGCGGGCGCGAGAGTTTCCATCGCACCACCCGAAGAGGTTTCCACGGCCGCCCTTCCGGTCCCGCGGCGC
ACTCCCCCAAGCGCCGCGCC

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNRSVPPSQTAPTAPARPYGAAPRGTCTLVGAGPGDPELLTLKALKAIQAATVLLVDDLVSDEIVALAAPGARVVHVGKR
GGCKSTPQAFIEKLMVMAVNEGENVVRLKGGDPFIFGRGGEEVEHLRAAGIEVTVVNGITAGLAGMTLLGTPLTHREHAH
GVVFVTGHAKPGDSGIDWRQLAATARAARLTLVIYMGVSSAAHIQEELLTGLPACTPVVIIQHVSLPCQRHALTTLGELH
ATIEREQLGSPSVIVVGDVAAGVAAAAGDGLGQPLPVAPPPLRHAG

Sequences:

>Translated_286_residues
MNRSVPPSQTAPTAPARPYGAAPRGTCTLVGAGPGDPELLTLKALKAIQAATVLLVDDLVSDEIVALAAPGARVVHVGKR
GGCKSTPQAFIEKLMVMAVNEGENVVRLKGGDPFIFGRGGEEVEHLRAAGIEVTVVNGITAGLAGMTLLGTPLTHREHAH
GVVFVTGHAKPGDSGIDWRQLAATARAARLTLVIYMGVSSAAHIQEELLTGLPACTPVVIIQHVSLPCQRHALTTLGELH
ATIEREQLGSPSVIVVGDVAAGVAAAAGDGLGQPLPVAPPPLRHAG
>Mature_286_residues
MNRSVPPSQTAPTAPARPYGAAPRGTCTLVGAGPGDPELLTLKALKAIQAATVLLVDDLVSDEIVALAAPGARVVHVGKR
GGCKSTPQAFIEKLMVMAVNEGENVVRLKGGDPFIFGRGGEEVEHLRAAGIEVTVVNGITAGLAGMTLLGTPLTHREHAH
GVVFVTGHAKPGDSGIDWRQLAATARAARLTLVIYMGVSSAAHIQEELLTGLPACTPVVIIQHVSLPCQRHALTTLGELH
ATIEREQLGSPSVIVVGDVAAGVAAAAGDGLGQPLPVAPPPLRHAG

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=48.3333333333333, Blast_Score=194, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6322922, Length=241, Percent_Identity=33.195020746888, Blast_Score=96, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 29270; Mature: 29270

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSVPPSQTAPTAPARPYGAAPRGTCTLVGAGPGDPELLTLKALKAIQAATVLLVDDLV
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHC
SDEIVALAAPGARVVHVGKRGGCKSTPQAFIEKLMVMAVNEGENVVRLKGGDPFIFGRGG
CCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHEEECCCCCEEEEECCCEEEECCCC
EEVEHLRAAGIEVTVVNGITAGLAGMTLLGTPLTHREHAHGVVFVTGHAKPGDSGIDWRQ
HHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHH
LAATARAARLTLVIYMGVSSAAHIQEELLTGLPACTPVVIIQHVSLPCQRHALTTLGELH
HHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATIEREQLGSPSVIVVGDVAAGVAAAAGDGLGQPLPVAPPPLRHAG
HHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRSVPPSQTAPTAPARPYGAAPRGTCTLVGAGPGDPELLTLKALKAIQAATVLLVDDLV
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHC
SDEIVALAAPGARVVHVGKRGGCKSTPQAFIEKLMVMAVNEGENVVRLKGGDPFIFGRGG
CCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHEEECCCCCEEEEECCCEEEECCCC
EEVEHLRAAGIEVTVVNGITAGLAGMTLLGTPLTHREHAHGVVFVTGHAKPGDSGIDWRQ
HHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHH
LAATARAARLTLVIYMGVSSAAHIQEELLTGLPACTPVVIIQHVSLPCQRHALTTLGELH
HHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATIEREQLGSPSVIVVGDVAAGVAAAAGDGLGQPLPVAPPPLRHAG
HHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]