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The map label for this gene is cysM [H]

Identifier: 120610667

GI number: 120610667

Start: 2156411

End: 2157331

Strand: Direct

Name: cysM [H]

Synonym: Aave_1987

Alternate gene names: 120610667

Gene position: 2156411-2157331 (Clockwise)

Preceding gene: 120610665

Following gene: 120610668

Centisome position: 40.29

GC content: 68.51

Gene sequence:

>921_bases
ATGGCTACCACCCCTTCCCCGACGTACCCCACCATCGAAGACGCGATCGGCCGCACGCCGCTGGTCGCCCTGCAGCGCAT
CGGCGCGCGGGAGAACGCCGAGCGCGGCACGGTCGTGCTGGGCAAGCTGGAGGGCAACAATCCGGCGGGTTCCGTGAAGG
ACCGGCCCGCGCTGTCCATGATCCGGCGCGCGGAGGAACGTGGGGAGATCAAGCAGGGTGACACGCTTATCGAGGCCACG
TCGGGCAATACGGGCATCGCGCTGGCGATGGCGGCGGCGATCAAGGGCTACCGGATGGTGCTGGTGATGCCGGAAGACCT
GTCGGTGGAGCGGGCGCAGACGATGAAGGCCTTCGGCGCGGAGCTGATCCTCACGCCCAAGAGCGGGGGCATGGAGTACG
CGCGCGACCTGGCCGAGACCATGGTGCGGCAGGGCAAGGGCGTGGTGCTCGACCAATTCGCCAATCCGGACAATCCGCGC
ATCCACTACGAGACCACCGGGCCCGAGCTGTGGGAGCAGACGGGCGGGCGCATCACGCATTTCGTGAGCGCGATGGGCAC
GACCGGCACGATCACCGGCGTGTCGCGCTTCCTGAAGGAAAAGAACCCCGCCATCCAGATCATCGGCGCGCAGCCCAAGG
AAGGGTCGCGCATTCCGGGCATCCGCAAGTGGCCGCAGGAATACCTGCCCAAGATCTACGATCCGCGCGCGGTGGACGAG
ACGATCAATGTCGGCCAGGACGATGCCGAGGACATGTGCCGCCGCCTCGCGCGCGAGGAAGGCATCTTCGCGGGCATCTC
CGCGGCGGGCGCCTGCTGGGCCGCGCAGGAGATCGCGCGGCGCGAGCGGGATGCGACCCTCGTCTTCGTGGTGTGCGACC
GGGGGGATCGTTACCTCTCCACGGGCGTGTTCCCCGCCTGA

Upstream 100 bases:

>100_bases
ACGCCTTGCGGCGGGGGATTTTGAGTCCCCTGCGTCTACCAATTTCACCACCCGGGCGACGCGAAGAAGGAAGCCCGGGA
TTATGGCACAGTAGGGGGCT

Downstream 100 bases:

>100_bases
CGCGGACTGACGTCTCTACACGCCTGGGTCCCGCTCCATGAACGCCGAGCCCCGCTTCTGCACCCAGTGCGCCACGCCGC
TGGCCTGGGTGACGGCGCTG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MATTPSPTYPTIEDAIGRTPLVALQRIGARENAERGTVVLGKLEGNNPAGSVKDRPALSMIRRAEERGEIKQGDTLIEAT
SGNTGIALAMAAAIKGYRMVLVMPEDLSVERAQTMKAFGAELILTPKSGGMEYARDLAETMVRQGKGVVLDQFANPDNPR
IHYETTGPELWEQTGGRITHFVSAMGTTGTITGVSRFLKEKNPAIQIIGAQPKEGSRIPGIRKWPQEYLPKIYDPRAVDE
TINVGQDDAEDMCRRLAREEGIFAGISAAGACWAAQEIARRERDATLVFVVCDRGDRYLSTGVFPA

Sequences:

>Translated_306_residues
MATTPSPTYPTIEDAIGRTPLVALQRIGARENAERGTVVLGKLEGNNPAGSVKDRPALSMIRRAEERGEIKQGDTLIEAT
SGNTGIALAMAAAIKGYRMVLVMPEDLSVERAQTMKAFGAELILTPKSGGMEYARDLAETMVRQGKGVVLDQFANPDNPR
IHYETTGPELWEQTGGRITHFVSAMGTTGTITGVSRFLKEKNPAIQIIGAQPKEGSRIPGIRKWPQEYLPKIYDPRAVDE
TINVGQDDAEDMCRRLAREEGIFAGISAAGACWAAQEIARRERDATLVFVVCDRGDRYLSTGVFPA
>Mature_305_residues
ATTPSPTYPTIEDAIGRTPLVALQRIGARENAERGTVVLGKLEGNNPAGSVKDRPALSMIRRAEERGEIKQGDTLIEATS
GNTGIALAMAAAIKGYRMVLVMPEDLSVERAQTMKAFGAELILTPKSGGMEYARDLAETMVRQGKGVVLDQFANPDNPRI
HYETTGPELWEQTGGRITHFVSAMGTTGTITGVSRFLKEKNPAIQIIGAQPKEGSRIPGIRKWPQEYLPKIYDPRAVDET
INVGQDDAEDMCRRLAREEGIFAGISAAGACWAAQEIARRERDATLVFVVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=312, Percent_Identity=37.1794871794872, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI295821200, Length=312, Percent_Identity=37.1794871794872, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI4557415, Length=312, Percent_Identity=37.1794871794872, Blast_Score=183, Evalue=1e-46,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=63.6054421768708, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=42.2077922077922, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=41.6393442622951, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=40.7284768211921, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=41.4141414141414, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=40.3333333333333, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=38.4105960264901, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147552, Length=285, Percent_Identity=36.140350877193, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.2641509433962, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=34.384858044164, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=34.0625, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=32.8313253012048, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=37.3376623376623, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=37.3376623376623, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33232; Mature: 33101

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTPSPTYPTIEDAIGRTPLVALQRIGARENAERGTVVLGKLEGNNPAGSVKDRPALSM
CCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHH
IRRAEERGEIKQGDTLIEATSGNTGIALAMAAAIKGYRMVLVMPEDLSVERAQTMKAFGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCC
ELILTPKSGGMEYARDLAETMVRQGKGVVLDQFANPDNPRIHYETTGPELWEQTGGRITH
EEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCHHHHHHCCCHHHH
FVSAMGTTGTITGVSRFLKEKNPAIQIIGAQPKEGSRIPGIRKWPQEYLPKIYDPRAVDE
HHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCHHHHCHHHCCCCHHHH
TINVGQDDAEDMCRRLAREEGIFAGISAAGACWAAQEIARRERDATLVFVVCDRGDRYLS
HHCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEC
TGVFPA
CCCCCC
>Mature Secondary Structure 
ATTPSPTYPTIEDAIGRTPLVALQRIGARENAERGTVVLGKLEGNNPAGSVKDRPALSM
CCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHH
IRRAEERGEIKQGDTLIEATSGNTGIALAMAAAIKGYRMVLVMPEDLSVERAQTMKAFGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCC
ELILTPKSGGMEYARDLAETMVRQGKGVVLDQFANPDNPRIHYETTGPELWEQTGGRITH
EEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCHHHHHHCCCHHHH
FVSAMGTTGTITGVSRFLKEKNPAIQIIGAQPKEGSRIPGIRKWPQEYLPKIYDPRAVDE
HHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCHHHHCHHHCCCCHHHH
TINVGQDDAEDMCRRLAREEGIFAGISAAGACWAAQEIARRERDATLVFVVCDRGDRYLS
HHCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEC
TGVFPA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]